| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 596 |
Name | BCL2 |
Synonymous | B-cell CLL/lymphoma 2;BCL2;B-cell CLL/lymphoma 2 |
Definition | apoptosis regulator Bcl-2|protein phosphatase 1, regulatory subunit 50 |
Position | 18q21.3 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
in same component |
BAD | IMID; |
in same component |
BAD | REACTOME; |
in same component |
BAG2 | IMID; |
in same component |
BAX | IMID; |
in same component |
BAX | NCI_NATURE; |
in same component |
BCAP31 | IMID; |
in same component |
BCL2L11 | IMID; |
in same component |
BID | IMID; |
in same component |
BID | REACTOME; |
in same component |
BIK | IMID; |
in same component |
FKBP8 | NCI_NATURE; |
in same component |
NR4A1 | NCI_NATURE; |
interacts with |
ATP2A2 | HPRD; |
interacts with |
AVEN | BIOGRID; |
interacts with |
BAD | BIOGRID; |
interacts with |
BAG1 | BIOGRID; |
interacts with |
BAG1 | HPRD; |
interacts with |
BAG3 | HPRD; |
interacts with |
BAG4 | HPRD; |
interacts with |
BAK1 | BIOGRID; |
interacts with |
BAK1 | HPRD; |
interacts with |
BAX | BIOGRID; |
interacts with |
BAX | HPRD; |
interacts with |
BAX | INTACT; |
interacts with |
Bax | MINT; |
interacts with |
BAX | MINT; |
interacts with |
BBC3 | BIOGRID; |
interacts with |
BBC3 | HPRD; |
interacts with |
BCAP31 | BIOGRID; |
interacts with |
BCAP31 | HPRD; |
interacts with |
BCL2L10 | BIOGRID; |
interacts with |
BCL2L10 | HPRD; |
interacts with |
Bcl2l11 | BIOGRID; |
interacts with |
BCL2L11 | BIOGRID; |
interacts with |
BCL2L11 | HPRD; |
interacts with |
BCL2L11 | INTACT; |
interacts with |
Bcl2l11 | MINT; |
interacts with |
BCL2L11 | MINT; |
interacts with |
BCL2L14 | HPRD; |
interacts with |
BCL2L1 | BIOGRID; |
interacts with |
BCL2L1 | HPRD; |
interacts with |
BCL2L1 | MINT; |
interacts with |
BCLAF1 | HPRD; |
interacts with |
Becn1 | BIOGRID; |
interacts with |
BECN1 | BIOGRID; |
interacts with |
BECN1 | HPRD; |
interacts with |
BECN1 | MINT; |
interacts with |
BFAR | HPRD; |
interacts with |
BID | BIOGRID; |
interacts with |
BIK | BIOGRID; |
interacts with |
BIK | HPRD; |
interacts with |
BLID | BIOGRID; |
interacts with |
BLK | BIOGRID; |
interacts with |
BLK | HPRD; |
interacts with |
BMF | BIOGRID; |
interacts with |
BMF | HPRD; |
interacts with |
BNIP1 | BIOGRID; |
interacts with |
BNIP1 | HPRD; |
interacts with |
BNIP2 | BIOGRID; |
interacts with |
BNIP2 | HPRD; |
interacts with |
BNIP3 | BIOGRID; |
interacts with |
BNIP3 | HPRD; |
interacts with |
BNIP3L | BIOGRID; |
interacts with |
BNIPL | BIOGRID; |
interacts with |
BNIPL | HPRD; |
interacts with |
CAPN2 | BIOGRID; |
interacts with |
CASP3 | BIOGRID; |
interacts with |
CASP3 | HPRD; |
interacts with |
CASP8 | BIOGRID; |
interacts with |
CASP8 | HPRD; |
interacts with |
CDK1 | BIOGRID; |
interacts with |
CDK2 | HPRD; |
interacts with |
CPT1A | HPRD; |
interacts with |
CYCS | HPRD; |
interacts with |
DAPK1 | MINT; |
interacts with |
DYNLL1 | BIOGRID; |
interacts with |
EPHB2 | BIOGRID; |
interacts with |
FKBP8 | BIOGRID; |
interacts with |
FKBP8 | HPRD; |
interacts with |
FKBP8 | MINT; |
interacts with |
HRAS | HPRD; |
interacts with |
HRK | BIOGRID; |
interacts with |
HRK | HPRD; |
interacts with |
IRS1 | BIOGRID; |
interacts with |
IRS2 | BIOGRID; |
interacts with |
ITM2B | BIOGRID; |
interacts with |
ITM2B | HPRD; |
interacts with |
ITPR1 | BIOGRID; |
interacts with |
ITPR1 | HPRD; |
interacts with |
KRAS | HPRD; |
interacts with |
LMNB1 | HPRD; |
interacts with |
MAPK11 | HPRD; |
interacts with |
MAPK14 | HPRD; |
interacts with |
MAPK1 | HPRD; |
interacts with |
MAPK1 | MINT; |
interacts with |
MAPK3 | HPRD; |
interacts with |
MAPK8 | HPRD; |
interacts with |
MAPK8 | MINT; |
interacts with |
MCL1 | MINT; |
interacts with |
MDM4 | MINT; |
interacts with |
MOAP1 | BIOGRID; |
interacts with |
MOAP1 | HPRD; |
interacts with |
MT-RNR2 | MINT; |
interacts with |
MYC | BIOGRID; |
interacts with |
MYC | HPRD; |
interacts with |
NAF1 | MINT; |
interacts with |
NMT2 | HPRD; |
interacts with |
NMT2 | MINT; |
interacts with |
NR4A1 | BIOGRID; |
interacts with |
NRAS | HPRD; |
interacts with |
PARK2 | BIOGRID; |
interacts with |
PARP1 | BIOGRID; |
interacts with |
PARP1 | HPRD; |
interacts with |
PIN1 | BIOGRID; |
interacts with |
PIN1 | HPRD; |
interacts with |
PKMYT1 | HPRD; |
interacts with |
PMAIP1 | BIOGRID; |
interacts with |
PMAIP1 | HPRD; |
interacts with |
PMAIP1 | INTACT; |
interacts with |
PPP1CA | HPRD; |
interacts with |
PPP2CA | BIOGRID; |
interacts with |
PPP2CA | HPRD; |
interacts with |
PPP2CA | MINT; |
interacts with |
PPP2R4 | BIOGRID; |
interacts with |
PPP2R5A | BIOGRID; |
interacts with |
PPP2R5A | HPRD; |
interacts with |
PPP3CA | BIOGRID; |
interacts with |
PPP3CA | HPRD; |
interacts with |
PPP3R1 | MINT; |
interacts with |
PRKACA | HPRD; |
interacts with |
PRKCA | HPRD; |
interacts with |
PSEN1 | BIOGRID; |
interacts with |
PSEN1 | HPRD; |
interacts with |
PXN | HPRD; |
interacts with |
RAD9A | BIOGRID; |
interacts with |
RAD9A | HPRD; |
interacts with |
RAF1 | BIOGRID; |
interacts with |
RAF1 | HPRD; |
interacts with |
RRAS | BIOGRID; |
interacts with |
RRAS | HPRD; |
interacts with |
RTN4 | BIOGRID; |
interacts with |
SERPINB8 | BIOGRID; |
interacts with |
SF1 | HPRD; |
interacts with |
SMN1 | BIOGRID; |
interacts with |
SMN1 | HPRD; |
interacts with |
SOD1 | BIOGRID; |
interacts with |
SOD1 | HPRD; |
interacts with |
SPNS1 | BIOGRID; |
interacts with |
SPNS1 | HPRD; |
interacts with |
TMBIM6 | BIOGRID; |
interacts with |
TMBIM6 | HPRD; |
interacts with |
TOMM20 | BIOGRID; |
interacts with |
TOMM20 | HPRD; |
interacts with |
TP53AIP1 | BIOGRID; |
interacts with |
TP53AIP1 | HPRD; |
interacts with |
TP53 | MINT; |
interacts with |
TP53BP2 | BIOGRID; |
interacts with |
TP53BP2 | MINT; |
Metabolic Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
metabolic catalysis |
ATF2 | NCI_NATURE; |
metabolic catalysis |
CREB1 | NCI_NATURE; |
metabolic catalysis |
CREBBP | NCI_NATURE; |
metabolic catalysis |
IKZF3 | NCI_NATURE; |
metabolic catalysis |
MAX | NCI_NATURE; |
metabolic catalysis |
MTOR | NCI_NATURE; |
metabolic catalysis |
MYB | NCI_NATURE; |
metabolic catalysis |
MYC | NCI_NATURE; |
metabolic catalysis |
POU4F1 | NCI_NATURE; |
metabolic catalysis |
STAT1 | NCI_NATURE; |
metabolic catalysis |
TP53 | NCI_NATURE; |
metabolic catalysis |
ZBTB17 | NCI_NATURE; |
Signaling Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
reacts with |
BAD | IMID; |
reacts with |
BAD | REACTOME; |
reacts with |
BAG2 | IMID; |
reacts with |
BAX | IMID; |
reacts with |
BAX | NCI_NATURE; |
reacts with |
BCAP31 | IMID; |
reacts with |
BCL2 | IMID; |
reacts with |
BCL2 | NCI_NATURE; |
reacts with |
BCL2 | REACTOME; |
reacts with |
BCL2L11 | IMID; |
reacts with |
BID | IMID; |
reacts with |
BID | REACTOME; |
reacts with |
BIK | IMID; |
reacts with |
CALM1 | NCI_NATURE; |
reacts with |
FKBP8 | NCI_NATURE; |
reacts with |
NR4A1 | NCI_NATURE; |
state change |
MAPK8 | NCI_NATURE; |
state change |
PPP1CC | IMID; |
state change |
PPP2R5C | IMID; |
state change |
PRKCA | IMID; |