| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5894 |
Name | RAF1 |
Synonymous | Raf-1 proto-oncogene, serine/threonine kinase;RAF1;Raf-1 proto-oncogene, serine/threonine kinase |
Definition | C-Raf proto-oncogene, serine/threonine kinase|Oncogene RAF1|RAF proto-oncogene serine/threonine-protein kinase|proto-oncogene c-RAF|raf proto-oncogene serine/threonine protein kinase|v-raf-1 murine leukemia viral oncogene homolog 1 |
Position | 3p25 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | H-Ras(h):GTP:NO + Raf-1(h) <==> H-Ras(h):GTP:NO:Raf-1(h) (binding) | bag1(m) + Bcl-2(h) + Raf-1(h) <==> bag1(m):Bcl-2(h):Raf-1(h) (binding) | 14-3-3epsilon(h) + Raf-1(h) <==> 14-3-3epsilon(h):Raf-1(h) (binding) | Cdc25A(h) + 14-3-3beta(h) + Raf-1(h) <==> Cdc25A(h):14-3-3beta(h):Raf-1(h) (binding) | Raf-1(h) + Cdc25A(h) <==> Raf-1(h):Cdc25A(h) (binding) | Raf-1(h) + Cdc25B(h) <==> Raf-1(h):Cdc25B(h) (binding) | Raf-1(h) + ATP --PAK3(r)--> Raf-1(h){pS338} + ADP (phosphorylation) | Raf-1(h) + ATP --PAK3a(m)--> Raf-1(h){pS338} + ADP (phosphorylation) | Raf-1(h) + 3 ATP --PKAc(m)--> Raf-1(h){pS43}{pS259}{pS621} + 3 ADP (phosphorylation) | Raf-1(h) + MEK1(r) <==> Raf-1(h):MEK1(r) (binding) | Raf-1(h) + 2 ATP --PKC(r)--> Raf-1(h){pS497}{pS619} + 2 ADP (phosphorylation) | Src(c) + Raf-1(h) <==> Src(c):Raf-1(h) (binding) | Raf-1(h) + 14-3-3zeta(b) <==> Raf-1(h):14-3-3zeta(b) (binding) | H-Ras(h):GTP + Raf-1(h) <==> H-Ras(h):GTP:Raf-1(h) (binding; translocation) | FasL(h):Fas(h):FADD(h):proCaspase-8(h):c-FLIP-L-p43(h) + Raf-1(h) <==> c-FLIP-L-p43(h):FADD(h):Fas(h):FasL(h):proCaspase-8(h):Raf-1(h) (binding) | Raf-1(h) + pRb(h) <==> Raf-1(h):pRb(h) (binding) | Raf-1(h) + p130(h) <==> Raf-1(h):p130(h) (binding) | E2F(h):DP(h) + pRb(h) + Raf-1(h) <==> E2F(h):DP(h):pRb(h):Raf-1(h) (binding) | Raf-1(h) + MEK2(m) <==> Raf-1(h):MEK2(m) (binding) | Raf-1(h) + ATP --KSR(m)--> Raf-1(h){pT269} + ADP (phosphorylation) | Raf-1(h) + MEK2(h) <==> Raf-1(h):MEK2(h) (binding) | Raf-1(h) + MEK1(m) <==> Raf-1(h):MEK1(m) (binding) | Raf-1(h) + ATP --PKCalpha(h)--> Raf-1(h){pS499} + ADP (phosphorylation) | Raf-1(h) + ATP --PKCbeta(h)--> Raf-1(h){p} + ADP (phosphorylation) | Raf-1(h) + ATP --PKCgamma(r)--> Raf-1(h){p} + ADP (phosphorylation) | 14-3-3eta(h) + Raf-1(h) <==> 14-3-3eta(h):Raf-1(h) (binding) | 14-3-3zeta(h) + Raf-1(h) <==> 14-3-3zeta(h):Raf-1(h) (binding) | A20(h) + 14-3-3(h) + Raf-1(h) <==> A20(h):14-3-3(h):Raf-1(h) (binding) | G-beta-1(v.s.):G-gamma-2(v.s.) + Raf-1(h) <==> G-beta-1(v.s.):G-gamma-2(v.s.):Raf-1(h) (binding) | angiotensin II(m.s.):AT1A(r){p} + beta-arrestin2(h) + ERK2(r) + MEK1(v.s.) + Raf-1(h) <==> angiotensin II(m.s.):AT1A(r){p}:beta-arrestin2(h):Raf-1(h):MEK1(v.s.):ERK2(r) (binding) | p65PAK(h){pT423} + Raf-1(h) <==> p65PAK(h){pT423}:Raf-1(h) (binding) | Raf-1(h) + RKIP(r) <==> Raf-1(h):RKIP(r) (binding) | Raf-1(h) + MEK1(h) <==> Raf-1(h):MEK1(h) (binding) | Raf-1(h) + H-Ras(h) <==> Raf-1(h):H-Ras(h) (binding) | Raf-1(h) + MEK1(m.s.) <==> Raf-1(h):MEK1(m.s.) (binding) | Raf-1(h) + Cnk1(h) <==> Raf-1(h):Cnk1(h) (binding) | Raf-1(h) + ATP --> Raf-1(h){pY} + ADP (phosphorylation) | PDK1(h) + MEK1(r) + Raf-1(h) <==> PDK1(h):MEK1(r):Raf-1(h) (binding) | MEK1(h) + Raf-1(h) <==> MEK1(h):Raf-1(h) (binding) | Raf-1(h) --> RSK(h){pT573} (increase of phosphorylation) | Raf-1(h) --> MAPK(h){pT202}{pY204} (increase of phosphorylation) | Raf-1(h) + Grb10zeta(h) <==> Raf-1(h):Grb10zeta(h) (binding) | H-Ras(m.s.):GTP + Raf-1(h) <==> H-Ras(m.s.):GTP:Raf-1(h) (binding) | Raf-1(h) + ATP --p65PAK(h)--> Raf-1(h){pS338} + ADP (phosphorylation) | Raf-1(h) + ATP --Src(m.s.)--> Raf-1(h){pY340} + ADP (phosphorylation) | Raf-1(h) + Bcl-2(h) <==> Raf-1(h):Bcl-2(h) (binding) | HCV-NS5A(HCV) + Raf-1(h) <==> HCV-NS5A(HCV):Raf-1(h) (binding) | Raf-1(h) --> Raf-1(h) (translocation) | Raf-1(h) + ATP --> Raf-1(h){pS338} + ADP (phosphorylation) | Raf-1(h) + ATP --> Raf-1(h) + ADP (phosphorylation; automodification) | 14-3-3tau(h) + Raf-1(h) <==> 14-3-3tau(h):Raf-1(h) (binding) | 14-3-3gamma(h) + Raf-1(h) <==> 14-3-3gamma(h):Raf-1(h) (binding) | 14-3-3sigma(m.s.) + Raf-1(h) <==> 14-3-3sigma(m.s.):Raf-1(h) (binding) | Ras(h):GTP + Raf-1(h) <==> Ras(h):GTP:Raf-1(h) (binding) | bag1(m) --> Raf-1(h) (activation) | RAF1(h) --> Raf-1(h) (expression). | Raf-1(h):Cdc25B(h) + ATP --> Raf-1(h) + Cdc25B(h){p} + ADP (phosphorylation; dissociation) | Raf-1(h):Cdc25A(h) + ATP --> Raf-1(h) + Cdc25A(h){p} + ADP (phosphorylation; dissociation) | Raf-1(h):MEK1(r) + ATP --> Raf-1(h) + MEK1(r){p} + ADP (phosphorylation; dissociation) | Raf-1(h):pRb(h) + ATP --> Raf-1(h) + pRb(h){p} + ADP (phosphorylation; dissociation) | Fas(h) --> Raf-1(h) (binding) | c-FLIP(m) --> Raf-1(h) (binding) | TRAF1(h) --> Raf-1(h) (binding) | TRAF2(h) --> Raf-1(h) (binding) | Raf-1(h) --> Raf-1(h) (translocation) | Raf-1(h) + ATP --> Raf-1(h) + ADP (phosphorylation; automodification) | bad(h) + ATP --Raf-1(h)--> bad(h){pS} + ADP (phosphorylation) | MEK(h) + ATP --Raf-1(h)--> MEK(h){pS} + ADP (phosphorylation) | MEK1(r) + 2 ATP --Raf-1(h)--> MEK1(r){pS218}{pS222} + 2 ADP (phosphorylation) | ERK(m.s.) + ATP --Raf-1(h)--> ERK(m.s.){p} + ADP (phosphorylation) | MEK(m.s.) + ATP --Raf-1(h)--> MEK(m.s.){p} + ADP (phosphorylation) | bad(m.s.) + ATP --Raf-1(h)--> bad(m.s.){pS112} + ADP (phosphorylation) | MEK1(m.s.) + ATP --Raf-1(h)--> MEK1(m.s.){p} + ADP (phosphorylation) | Raf-1(h) + Hsp50(r) <==> Raf-1(h):Hsp50(r) (binding) | Ras(r):GTP + Raf-1(h) <==> Ras(r):GTP:Raf-1(h) (binding) | Raf-1(h) --> CDKN2B(m) (transactivation) | Raf-1(h) --> CDKN2A(m) (transactivation) | Raf-1(h) + Ras(h):GTP <==> Raf-1(h):Ras(h):GTP (binding) | RAF1(h) --> Raf-1(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 43 | Phosphoserine. | Swiss-Prot 53.0 | 259 | Phosphoserine (by PKC). | Swiss-Prot 53.0 | 268 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 | 294 | Phosphoserine. | Swiss-Prot 53.0 | 301 | Phosphoserine. | Swiss-Prot 53.0 | 338 | Phosphoserine (by PAK2 and PAK3). | Swiss-Prot 53.0 | 499 | Phosphoserine (by PKC). | Swiss-Prot 53.0 | 621 | Phosphoserine. | Swiss-Prot 53.0 | 341 | Phosphotyrosine (Src) | 10205168 | Phospho.ELM 6.0 | 338 | Phosphoserine (PAK1;PAK3;PA) | 11376654;11733498;12719581;10801448;9823899 | Phospho.ELM 6.0 | 340 | Phosphotyrosine | 11134016 | Phospho.ELM 6.0 | 233 | Phosphoserine | 12801936 | Phospho.ELM 6.0 | 494 | Phosphoserine | 15258589 | Phospho.ELM 6.0 | 289 | Phosphoserine | 15664191 | Phospho.ELM 6.0 | 29 | Phosphoserine | 15664191 | Phospho.ELM 6.0 | 296 | Phosphoserine | 15664191 | Phospho.ELM 6.0 | 301 | Phosphoserine | 15664191;17081983 | Phospho.ELM 6.0 | 339 | Phosphoserine (PAK1) | 15849194 | Phospho.ELM 6.0 | 471 | Phosphoserine | 16093354 | Phospho.ELM 6.0 | 491 | Phosphothreonine | 15258589;11447113 | Phospho.ELM 6.0 | 269 | Phosphothreonine (KSR1) | 11134016;7477354 | Phospho.ELM 6.0 | 294 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr3 |
Promoter: 12680178 - 12682178 | Agilent_014791 |
chr3 |
Promoter: 12680178 - 12682178 | GoldenGate_Methylation_Cancer_Panel_I |
chr3 |
Promoter: 12680178 - 12682178 | GSE27584 |
chr3 |
Promoter: 12680178 - 12682178 | Agilent_014791_44K |