| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5894 |
Name | RAF1 |
Synonymous | Raf-1 proto-oncogene, serine/threonine kinase;RAF1;Raf-1 proto-oncogene, serine/threonine kinase |
Definition | C-Raf proto-oncogene, serine/threonine kinase|Oncogene RAF1|RAF proto-oncogene serine/threonine-protein kinase|proto-oncogene c-RAF|raf proto-oncogene serine/threonine protein kinase|v-raf-1 murine leukemia viral oncogene homolog 1 |
Position | 3p25 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
in same component |
AKT1 | NCI_NATURE; |
in same component |
BAG2 | IMID; |
in same component |
CNKSR1 | IMID; |
in same component |
HRAS | REACTOME; |
in same component |
MAP2K1 | REACTOME; |
in same component |
MAP2K2 | REACTOME; |
in same component |
NRAS | IMID; |
in same component |
PEBP1 | NCI_NATURE; |
in same component |
RAP1A | IMID; |
in same component |
RHEB | IMID; |
in same component |
YWHAB | REACTOME; |
in same component |
YWHAE | NCI_NATURE; |
in same component |
YWHAH | IMID; |
in same component |
YWHAZ | NCI_NATURE; |
in same component |
YWHAZ | REACTOME; |
interacts with |
ADCY6 | HPRD; |
interacts with |
AGTR1 | HPRD; |
interacts with |
AKT1 | BIOGRID; |
interacts with |
AKT1 | CELL_MAP; |
interacts with |
AKT1 | HPRD; |
interacts with |
AKT1 | MINT; |
interacts with |
AR | BIOGRID; |
interacts with |
AR | HPRD; |
interacts with |
Arrb2 | BIOGRID; |
interacts with |
ARRB2 | HPRD; |
interacts with |
BAG1 | BIOGRID; |
interacts with |
BAG1 | HPRD; |
interacts with |
BAG1 | MINT; |
interacts with |
BCL2L1 | BIOGRID; |
interacts with |
BCL2 | BIOGRID; |
interacts with |
BCL2 | HPRD; |
interacts with |
BIRC2 | BIOGRID; |
interacts with |
BIRC3 | BIOGRID; |
interacts with |
CCT3 | BIOGRID; |
interacts with |
CCT3 | MINT; |
interacts with |
CDC25A | BIOGRID; |
interacts with |
CDC25A | HPRD; |
interacts with |
CFLAR | BIOGRID; |
interacts with |
CFLAR | HPRD; |
interacts with |
CNKSR1 | BIOGRID; |
interacts with |
CNKSR1 | MINT; |
interacts with |
CNKSR2 | BIOGRID; |
interacts with |
COPS3 | HPRD; |
interacts with |
DMPK | HPRD; |
interacts with |
EEF1A1 | BIOGRID; |
interacts with |
EFEMP1 | HPRD; |
interacts with |
ERAS | BIOGRID; |
interacts with |
ERBB2IP | HPRD; |
interacts with |
FYN | BIOGRID; |
interacts with |
FYN | HPRD; |
interacts with |
GNG2 | HPRD; |
interacts with |
GNG4 | BIOGRID; |
interacts with |
GNG4 | HPRD; |
interacts with |
GRB10 | BIOGRID; |
interacts with |
GRB10 | HPRD; |
interacts with |
Hras1 | BIOGRID; |
interacts with |
HRAS | BIOGRID; |
interacts with |
HRAS | CELL_MAP; |
interacts with |
HRAS | HPRD; |
interacts with |
HRAS | MINT; |
interacts with |
HSP82 | BIOGRID; |
interacts with |
HSP90AA1 | BIOGRID; |
interacts with |
HSP90AA1 | HPRD; |
interacts with |
HSPA4 | HPRD; |
interacts with |
HSPA8 | BIOGRID; |
interacts with |
HSPA8 | HPRD; |
interacts with |
IL2RB | HPRD; |
interacts with |
INSR | HPRD; |
interacts with |
INTS10 | HPRD; |
interacts with |
JAK1 | BIOGRID; |
interacts with |
JAK1 | HPRD; |
interacts with |
JAK2 | BIOGRID; |
interacts with |
JAK2 | HPRD; |
interacts with |
KRAS | BIOGRID; |
interacts with |
KRAS | HPRD; |
interacts with |
KRT18 | HPRD; |
interacts with |
KRT18 | MINT; |
interacts with |
KRT19 | MINT; |
interacts with |
KRT8 | HPRD; |
interacts with |
KRT8 | MINT; |
interacts with |
KSR1 | HPRD; |
interacts with |
KSR2 | HPRD; |
interacts with |
LCK | BIOGRID; |
interacts with |
LCK | HPRD; |
interacts with |
LRPAP1 | BIOGRID; |
interacts with |
LTK | BIOGRID; |
interacts with |
MAP2K1 | BIOGRID; |
interacts with |
MAP2K1 | CELL_MAP; |
interacts with |
MAP2K1 | HPRD; |
interacts with |
MAP2K1 | MINT; |
interacts with |
MAP2K2 | HPRD; |
interacts with |
MAP3K1 | BIOGRID; |
interacts with |
MAP3K1 | HPRD; |
interacts with |
MAP3K5 | BIOGRID; |
interacts with |
MAP3K5 | HPRD; |
interacts with |
MAPK1 | BIOGRID; |
interacts with |
MAPK1 | HPRD; |
interacts with |
MAPK3 | BIOGRID; |
interacts with |
MAPK3 | HPRD; |
interacts with |
MAPK3 | MINT; |
interacts with |
MAPK7 | BIOGRID; |
interacts with |
MAPK7 | HPRD; |
interacts with |
MAPK8IP3 | BIOGRID; |
interacts with |
MAPK8IP3 | HPRD; |
interacts with |
MRAS | BIOGRID; |
interacts with |
MRAS | HPRD; |
interacts with |
Mras | MINT; |
interacts with |
MST4 | BIOGRID; |
interacts with |
MST4 | HPRD; |
interacts with |
MYC | BIOGRID; |
interacts with |
MYC | HPRD; |
interacts with |
NR3C1 | BIOGRID; |
interacts with |
NR3C1 | HPRD; |
interacts with |
NRAS | BIOGRID; |
interacts with |
NRAS | HPRD; |
interacts with |
NUDT14 | HPRD; |
interacts with |
OIP5 | BIOGRID; |
interacts with |
OIP5 | HPRD; |
interacts with |
PAK1 | BIOGRID; |
interacts with |
PAK1 | HPRD; |
interacts with |
PAK1 | MINT; |
interacts with |
PAK2 | HPRD; |
interacts with |
PBK | HPRD; |
interacts with |
PDGFRB | BIOGRID; |
interacts with |
PDGFRB | HPRD; |
interacts with |
PEBP1 | BIOGRID; |
interacts with |
PEBP1 | CELL_MAP; |
interacts with |
PEBP1 | HPRD; |
interacts with |
PEBP1 | MINT; |
interacts with |
PEBP4 | BIOGRID; |
interacts with |
PEBP4 | MINT; |
interacts with |
PEX5L | HPRD; |
interacts with |
PHB | BIOGRID; |
interacts with |
PHB | HPRD; |
interacts with |
PHKA2 | BIOGRID; |
interacts with |
PIN1 | HPRD; |
interacts with |
PKM2 | HPRD; |
interacts with |
PKM2 | MINT; |
interacts with |
PPP1CC | HPRD; |
interacts with |
PRKAA1 | HPRD; |
interacts with |
PRKACA | HPRD; |
interacts with |
PRKCA | HPRD; |
interacts with |
PRKCD | HPRD; |
interacts with |
PRKCE | BIOGRID; |
interacts with |
PRKCE | HPRD; |
interacts with |
PRKCZ | BIOGRID; |
interacts with |
PRKCZ | HPRD; |
interacts with |
PRKG1 | BIOGRID; |
interacts with |
PRKG1 | HPRD; |
interacts with |
PRPF6 | BIOGRID; |
interacts with |
RAP1A | BIOGRID; |
interacts with |
RAP1A | HPRD; |
interacts with |
RAP1A | MINT; |
interacts with |
RAP2A | HPRD; |
interacts with |
RASA1 | HPRD; |
interacts with |
RASD2 | BIOGRID; |
interacts with |
RB1 | BIOGRID; |
interacts with |
RB1 | HPRD; |
interacts with |
RB1 | INTACT; |
interacts with |
RBL2 | BIOGRID; |
interacts with |
RBL2 | HPRD; |
interacts with |
Rfxank | CELL_MAP; |
interacts with |
RFXANK | HPRD; |
interacts with |
RHEB | BIOGRID; |
interacts with |
RHEB | HPRD; |
interacts with |
RHEB | MINT; |
interacts with |
RRAS | BIOGRID; |
interacts with |
RSU1 | HPRD; |
interacts with |
SFN | BIOGRID; |
interacts with |
SFN | MINT; |
interacts with |
SHOC2 | BIOGRID; |
interacts with |
SHOC2 | CELL_MAP; |
interacts with |
SHOC2 | HPRD; |
interacts with |
SPRY2 | BIOGRID; |
interacts with |
SPRY2 | HPRD; |
interacts with |
SPRY4 | BIOGRID; |
interacts with |
SPRY4 | HPRD; |
interacts with |
SRC | BIOGRID; |
interacts with |
SRC | HPRD; |
interacts with |
STK3 | HPRD; |
interacts with |
STUB1 | BIOGRID; |
interacts with |
TIMM50 | HPRD; |
interacts with |
TSC22D3 | BIOGRID; |
interacts with |
TSC22D3 | HPRD; |
interacts with |
UBE2D2 | BIOGRID; |
interacts with |
VAV1 | BIOGRID; |
interacts with |
VAV1 | HPRD; |
interacts with |
VDAC1 | BIOGRID; |
interacts with |
VDAC1 | HPRD; |
interacts with |
XIAP | BIOGRID; |
interacts with |
YWHAB | BIOGRID; |
interacts with |
YWHAB | HPRD; |
interacts with |
YWHAB | MINT; |
interacts with |
YWHAE | BIOGRID; |
interacts with |
YWHAE | HPRD; |
interacts with |
YWHAE | MINT; |
interacts with |
YWHAG | BIOGRID; |
interacts with |
YWHAG | HPRD; |
interacts with |
YWHAG | MINT; |
interacts with |
YWHAH | BIOGRID; |
interacts with |
YWHAH | HPRD; |
interacts with |
YWHAH | MINT; |
interacts with |
YWHAQ | BIOGRID; |
interacts with |
YWHAQ | MINT; |
interacts with |
YWHAZ | BIOGRID; |
interacts with |
YWHAZ | HPRD; |
interacts with |
YWHAZ | MINT; |
Metabolic Interaction [Top] | ||
There is no record for RAF1 | ||
Signaling Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
reacts with |
AKT1 | NCI_NATURE; |
reacts with |
BAG2 | IMID; |
reacts with |
CNKSR1 | IMID; |
reacts with |
HRAS | REACTOME; |
reacts with |
MAP2K1 | REACTOME; |
reacts with |
MAP2K2 | REACTOME; |
reacts with |
NRAS | IMID; |
reacts with |
PEBP1 | NCI_NATURE; |
reacts with |
RAF1 | IMID; |
reacts with |
RAF1 | NCI_NATURE; |
reacts with |
RAF1 | REACTOME; |
reacts with |
RAP1A | IMID; |
reacts with |
RHEB | IMID; |
reacts with |
YWHAB | REACTOME; |
reacts with |
YWHAE | NCI_NATURE; |
reacts with |
YWHAH | IMID; |
reacts with |
YWHAZ | NCI_NATURE; |
reacts with |
YWHAZ | REACTOME; |
state change |
AKT1 | CELL_MAP; |
state change |
AKT1 | IMID; |
state change |
AKT1 | NCI_NATURE; |
state change |
CERK | IMID; |
state change |
DOK1 | NCI_NATURE; |
state change |
FCER1A | NCI_NATURE; |
state change |
FCER1G | NCI_NATURE; |
state change |
FCGR2B | NCI_NATURE; |
state change |
HRAS | NCI_NATURE; |
state change |
INPP5D | NCI_NATURE; |
state change |
KSR1 | NCI_NATURE; |
state change |
LCK | IMID; |
state change |
MS4A2 | NCI_NATURE; |
state change |
PAK1 | IMID; |
state change |
PAK1 | NCI_NATURE; |
state change |
PIN1 | NCI_NATURE; |
state change |
PPP2CA | NCI_NATURE; |
state change |
PPP2R1A | NCI_NATURE; |
state change |
PPP2R2A | NCI_NATURE; |
state change |
PPP2R2B | NCI_NATURE; |
state change |
PPP5C | NCI_NATURE; |
state change |
PRKACA | IMID; |
state change |
PRKCA | IMID; |
state change |
PRKCA | NCI_NATURE; |
state change |
PRKCB | NCI_NATURE; |
state change |
PRKCD | NCI_NATURE; |
state change |
PRKCZ | NCI_NATURE; |
state change |
RAF1 | REACTOME; |
state change |
RASA1 | NCI_NATURE; |
state change |
RRAS | NCI_NATURE; |
state change |
YWHAB | REACTOME; |
state change |
YWHAZ | NCI_NATURE; |