Entrez Gene

Basic Information
Gene ID	5609
Name	MAP2K7
Synonymous	mitogen-activated protein kinase kinase 7;MAP2K7;mitogen-activated protein kinase kinase 7
Definition	JNK-activating kinase 2\|MAP kinase kinase 7\|MAPK/ERK kinase 7\|SAPK kinase 4\|c-Jun N-terminal kinase kinase 2\|dual specificity mitogen-activated protein kinase kinase 7\|stress-activated protein kinase kinase 4
Position	19p13.3-p13.2
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
MKK7(h) + ATP --MEKK1(m){p}--> MKK7(h){p} + ADP (phosphorylation)
MKK7(h) + ATP --MLK2(h)--> MKK7(h){p} + ADP (phosphorylation)
MEKK2(h) + MKK7(h) <==> MEKK2(h):MKK7(h) (binding)
MKK7(h) + JNK1(h) <==> MKK7(h):JNK1(h) (binding)
MEKK2(h) + MKK7(h) + JNK1(h) <==> MEKK2(h):MKK7(h):JNK1(h) (binding)
MKK7(h) + ATP --MEKK2(h)--> MKK7(h){p} + ADP (phosphorylation)
MKK7(h) + GADD45-beta(m.s.) <==> MKK7(h):GADD45-beta(m.s.) (binding)
MKK7(h) + ATP --> MKK7(h){p} + ADP (phosphorylation)
MAP2K7(h) --> MKK7(h) (expression).
HCV-NS5A(HCV) + ATP --MKK7(h)--> HCV-NS5A(HCV){p} + ADP (phosphorylation)
JNK2alpha-2(h) + 2 ATP --MKK7(h)--> JNK2alpha-2(h){pT404}{pS407} + 2 ADP (phosphorylation)
MKK7-isoform1(h) + JNK1alpha1(h) <==> MKK7-isoform1(h):JNK1alpha1(h) (binding)
MKK7-isoform1(h) + 2 ATP --MLK3(m.s.)--> MKK7-isoform1(h){pS271}{pT275} + 2 ADP (phosphorylation)
MAP2K7(h) --> MKK7-isoform1(h) (expression).
MAP2K7(h) --> MKK7-Isoform2(h) (expression).
MAP2K7(h) --> MKK7-Isoform3(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
271	Phosphoserine (MAP3K1)	9312068	Phospho.ELM 6.0
275	Phosphothreonine (MAP3K1)	9312068	Phospho.ELM 6.0

Transcription Factors [Top]