Entrez Gene

Basic Information
Gene ID	5609
Name	MAP2K7
Synonymous	mitogen-activated protein kinase kinase 7;MAP2K7;mitogen-activated protein kinase kinase 7
Definition	JNK-activating kinase 2\|MAP kinase kinase 7\|MAPK/ERK kinase 7\|SAPK kinase 4\|c-Jun N-terminal kinase kinase 2\|dual specificity mitogen-activated protein kinase kinase 7\|stress-activated protein kinase kinase 4
Position	19p13.3-p13.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1133G>T; p.S378I; 19:7912304-7912304	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.748C>G; p.L250V; 19:7911052-7911052	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.484C>T; p.R162C; 19:7910489-7910489	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.484C>T; p.R162C; 19:7910489-7910489	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.484C>T; p.R162C; 19:7910489-7910489	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.484C>T; p.R162C; 19:7910489-7910489	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.922C>A; p.L308M; 19:7911316-7911316	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.824C>T; p.T275M; 19:7911128-7911128	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.265A>T; p.S89C; 19:7909895-7909895	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.824C>T; p.T275M; 19:7911128-7911128	ovary	other; neoplasm	Substitution - Missense
c.824C>T; p.T275M; 19:7911128-7911128	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.824C>T; p.T275M; 19:7911128-7911128	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.573C>T; p.D191D; 19:7910701-7910701	breast	carcinoma	Substitution - coding silent
c.646G>A; p.E216K; 19:7910774-7910774	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.458G>T; p.R153L; 19:7910463-7910463	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.573C>T; p.D191D; 19:7910701-7910701	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.458G>T; p.R153L; 19:7910463-7910463	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.516G>A; p.K172K; 19:7910521-7910521	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.22C>T; p.Q8*; 19:7903966-7903966	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.417C>T; p.F139F; 19:7910343-7910343	skin	malignant_melanoma	Substitution - coding silent
c.333+2T>C; p.?; 19:7910131-7910131	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.757G>A; p.E253K; 19:7911061-7911061	skin	malignant_melanoma	Substitution - Missense
c.1080-1G>A; p.?; 19:7912148-7912148	skin	malignant_melanoma	Unknown
c.1099A>T; p.K367*; 19:7912168-7912168	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Nonsense
c.980C>T; p.T327M; 19:7911479-7911479	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.980C>T; p.T327M; 19:7911479-7911479	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.952G>T; p.G318*; 19:7911451-7911451	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.952G>T; p.G318*; 19:7911451-7911451	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.952G>T; p.G318*; 19:7911451-7911451	large_intestine; colon	carcinoma	Substitution - Nonsense
c.952G>T; p.G318*; 19:7911451-7911451	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.329_330insG; p.Q111fs*39; 19:7910125-7910126	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.485G>A; p.R162H; 19:7910490-7910490	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.485G>A; p.R162H; 19:7910490-7910490	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.712G>T; p.G238C; 19:7911016-7911016	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.937-2A>C; p.?; 19:7911434-7911434	stomach	carcinoma; intestinal_adenocarcinoma	Unknown
c.1049C>T; p.S350L; 19:7911548-7911548	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.40G>T; p.E14*; 19:7903984-7903984	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.870C>T; p.D290D; 19:7911264-7911264	ovary	other; neoplasm	Substitution - coding silent
c.33C>T; p.S11S; 19:7903977-7903977	skin	malignant_melanoma	Substitution - coding silent
c.1023G>A; p.P341P; 19:7911522-7911522	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1240C>T; p.H414Y; 19:7912411-7912411	skin	malignant_melanoma	Substitution - Missense
c.534C>T; p.Y178Y; 19:7910539-7910539	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1172C>T; p.A391V; 19:7912343-7912343	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1225G>A; p.V409I; 19:7912396-7912396	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.896A>G; p.Y299C; 19:7911290-7911290	stomach	adenocarcinoma	Substitution - Missense
c.381C>G; p.G127G; 19:7910307-7910307	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.743A>G; p.N248S; 19:7911047-7911047	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1059C>T; p.F353F; 19:7911558-7911558	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.937-9_937-8CC>TT; p.?; 19:7911427-7911428	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.458G>A; p.R153H; 19:7910463-7910463	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.458G>A; p.R153H; 19:7910463-7910463	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.458G>A; p.R153H; 19:7910463-7910463	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.458G>A; p.R153H; 19:7910463-7910463	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.458G>A; p.R153H; 19:7910463-7910463	large_intestine; colon	carcinoma	Substitution - Missense
c.458G>A; p.R153H; 19:7910463-7910463	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.405G>A; p.W135*; 19:7910331-7910331	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.325delG; p.G110fs*62; 19:7910121-7910121	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.67G>A; p.E23K; 19:7904011-7904011	urinary_tract; bladder	carcinoma	Substitution - Missense
c.674C>T; p.A225V; 19:7910802-7910802	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.798C>T; p.G266G; 19:7911102-7911102	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.771C>T; p.I257I; 19:7911075-7911075	skin	malignant_melanoma	Substitution - coding silent
c.463G>A; p.G155R; 19:7910468-7910468	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.457C>T; p.R153C; 19:7910462-7910462	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.457C>T; p.R153C; 19:7910462-7910462	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.937-1G>A; p.?; 19:7911435-7911435	large_intestine	carcinoma; adenocarcinoma	Unknown
c.937-1G>A; p.?; 19:7911435-7911435	large_intestine	carcinoma; adenocarcinoma	Unknown
c.1081C>T; p.L361F; 19:7912150-7912150	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.727G>A; p.D243N; 19:7911031-7911031	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.727G>A; p.D243N; 19:7911031-7911031	large_intestine; colon	adenoma	Substitution - Missense
c.727G>A; p.D243N; 19:7911031-7911031	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.727G>A; p.D243N; 19:7911031-7911031	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.727G>A; p.D243N; 19:7911031-7911031	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.727G>A; p.D243N; 19:7911031-7911031	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.394G>C; p.G132R; 19:7910320-7910320	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.582C>T; p.I194I; 19:7910710-7910710	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.932C>T; p.S311L; 19:7911326-7911326	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.904C>T; p.R302W; 19:7911298-7911298	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.686C>T; p.A229V; 19:7910990-7910990	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.905G>T; p.R302L; 19:7911299-7911299	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.686C>T; p.A229V; 19:7910990-7910990	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.795C>A; p.S265R; 19:7911099-7911099	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1101G>A; p.K367K; 19:7912170-7912170	breast	carcinoma; HER-positive_carcinoma	Substitution - coding silent
c.1125+1G>A; p.?; 19:7912195-7912195	large_intestine	carcinoma; adenocarcinoma	Unknown
c.1125+1G>A; p.?; 19:7912195-7912195	large_intestine	carcinoma; adenocarcinoma	Unknown
c.308C>T; p.T103M; 19:7910104-7910104	pancreas	carcinoma	Substitution - Missense
c.308C>T; p.T103M; 19:7910104-7910104	urinary_tract; bladder	carcinoma	Substitution - Missense
c.14C>T; p.S5F; 19:7903958-7903958	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.725G>A; p.R242H; 19:7911029-7911029	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.5C>T; p.A2V; 19:7903949-7903949	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454C>T; p.R152W; 19:7910459-7910459	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.725G>A; p.R242H; 19:7911029-7911029	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.844G>A; p.A282T; 19:7911148-7911148	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.355G>T; p.D119Y; 19:7910281-7910281	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.961C>T; p.P321S; 19:7911460-7911460	skin	malignant_melanoma	Substitution - Missense
c.859G>A; p.E287K; 19:7911253-7911253	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.859G>A; p.E287K; 19:7911253-7911253	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.274_275insTT; p.D93fs*9; 19:7910070-7910071	breast	carcinoma	Insertion - Frameshift
c.811T>A; p.S271T; 19:7911115-7911115	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.440C>T; p.A147V; 19:7910366-7910366	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.420G>A; p.R140R; 19:7910346-7910346	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.853G>A; p.A285T; 19:7911157-7911157	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.872_873CC>TT; p.P291L; 19:7911266-7911267	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.947C>A; p.A316E; 19:7911446-7911446	pancreas	carcinoma	Substitution - Missense
c.781G>A; p.D261N; 19:7911085-7911085	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.826C>A; p.R276R; 19:7911130-7911130	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.781G>A; p.D261N; 19:7911085-7911085	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1033G>A; p.G345R; 19:7911532-7911532	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.781G>A; p.D261N; 19:7911085-7911085	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.385G>A; p.G129S; 19:7910311-7910311	pancreas	carcinoma	Substitution - Missense
c.394G>A; p.G132S; 19:7910320-7910320	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.385G>A; p.G129S; 19:7910311-7910311	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.385G>A; p.G129S; 19:7910311-7910311	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1009C>T; p.Q337*; 19:7911508-7911508	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.913G>A; p.V305I; 19:7911307-7911307	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.354C>T; p.N118N; 19:7910280-7910280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.856-8C>G; p.?; 19:7911242-7911242	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.905G>A; p.R302Q; 19:7911299-7911299	oesophagus	carcinoma	Substitution - Missense
c.538G>A; p.V180M; 19:7910543-7910543	pancreas	carcinoma	Substitution - Missense
c.538G>A; p.V180M; 19:7910543-7910543	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.954A>G; p.G318G; 19:7911453-7911453	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.626G>A; p.R209Q; 19:7910754-7910754	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.461C>A; p.S154Y; 19:7910466-7910466	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1156C>T; p.L386L; 19:7912327-7912327	liver	carcinoma	Substitution - coding silent
c.1078T>C; p.C360R; 19:7911577-7911577	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1156C>T; p.L386L; 19:7912327-7912327	liver	carcinoma	Substitution - coding silent
c.1087A>G; p.K363E; 19:7912156-7912156	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.462C>T; p.S154S; 19:7910467-7910467	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.870delC; p.P292fs*119; 19:7911264-7911264	NS	malignant_melanoma	Deletion - Frameshift
c.870delC; p.P292fs*119; 19:7911264-7911264	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.569C>T; p.T190M; 19:7910697-7910697	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.275_276insTT; p.D93fs*9; 19:7910071-7910072	breast	carcinoma	Insertion - Frameshift
c.1055A>G; p.D352G; 19:7911554-7911554	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.447+2T>C; p.?; 19:7910375-7910375	stomach	carcinoma; adenocarcinoma	Unknown
c.1193T>C; p.M398T; 19:7912364-7912364	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.83_84insC; p.D29fs*63; 19:7904027-7904028	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.215G>A; p.R72H; 19:7909845-7909845	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.386G>A; p.G129D; 19:7910312-7910312	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1037A>C; p.H346P; 19:7911536-7911536	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1126-2A>G; p.?; 19:7912295-7912295	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1149C>T; p.Y383Y; 19:7912320-7912320	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.124+1G>A; p.?; 19:7904069-7904069	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1080-1G>C; p.?; 19:7912148-7912148	oesophagus	carcinoma; adenocarcinoma	Unknown
c.1173G>A; p.A391A; 19:7912344-7912344	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.90C>G; p.L30L; 19:7904034-7904034	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1063T>C; p.S355P; 19:7911562-7911562	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.690G>T; p.L230L; 19:7910994-7910994	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.827G>A; p.R276Q; 19:7911131-7911131	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1050delG; p.D352fs*59; 19:7911549-7911549	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.727G>T; p.D243Y; 19:7911031-7911031	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1196C>T; p.A399V; 19:7912367-7912367	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1196C>T; p.A399V; 19:7912367-7912367	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1086T>C; p.T362T; 19:7912155-7912155	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1022C>T; p.P341L; 19:7911521-7911521	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1247C>T; p.P416L; 19:7912418-7912418	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1022C>T; p.P341L; 19:7911521-7911521	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1022C>T; p.P341L; 19:7911521-7911521	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.872C>T; p.P291L; 19:7911266-7911266	skin	malignant_melanoma	Substitution - Missense
c.730G>A; p.V244I; 19:7911034-7911034	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.730G>A; p.V244I; 19:7911034-7911034	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.730G>A; p.V244I; 19:7911034-7911034	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1022C>T; p.P341L; 19:7911521-7911521	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1144C>T; p.R382C; 19:7912315-7912315	stomach	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]