| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5608 |
Name | MAP2K6 |
Synonymous | mitogen-activated protein kinase kinase 6;MAP2K6;mitogen-activated protein kinase kinase 6 |
Definition | MAPK/ERK kinase 6|MAPKK 6|MEK 6|SAPK kinase 3|dual specificity mitogen-activated protein kinase kinase 6|protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)|stress-activated protein kinase kinase 3 |
Position | 17q24.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | MKK6-isoform1(h) + ATP --TAK1(m){p}--> MKK6-isoform1(h){p} + ADP (dephosphorylation) | MAP2K6(h) --> MKK6-isoform1(h) (expression). | p38beta1(h) + ATP --MKK6-isoform1(h)--> p38beta1(h){p} + ADP (phosphorylation) | MAP2K6(h) --> MKK6-isoform2(h) (expression). | MKK6(h) + ATP --TAK1(m)--> MKK6(h){p} + ADP (phosphorylation) | MKK6(h) + ATP --TRAF6(m){ub{K63}(n)}:TAB2(h):TAK1(m):TAB1(h)--> MKK6(h){p} + ADP (phosphorylation) | MKK6(h) + ATP --ASK1(h)--> MKK6(h){p} + ADP (phosphorylation) | MKK6(h) + ATP --MLK2(h)--> MKK6(h){p} + ADP (phosphorylation) | MKK6(h) + ATP --Cot(h)--> MKK6(h){p} + ADP (phosphorylation) | MKK6(h) + ATP --MEKK4(h)--> MKK6(h){p} + ADP (phosphorylation) | MKK6(h) + ATP --TAK1(h)--> MKK6(h){p} + ADP (phosphorylation) | MKK6(h) + NTP --MLTK-isoform1(m)--> MKK6(h){p} + NDP (phosphorylation) | MKK6(h) + NTP --MLTK-isoform2(m)--> MKK6(h){p} + NDP (phosphorylation) | TAO2(h) + MKK6(h) <==> TAO2(h):MKK6(h) (binding) | MKK6(h) + p38delta(h) <==> MKK6(h):p38delta(h) (binding) | MKK6(h) + p38alpha(h) <==> MKK6(h):p38alpha(h) (binding) | MKK6(h) --/ KLK3(h) (transrepression) | MKK6(h) + ATP --PKR(h)--> MKK6(h){p} + ADP (phosphorylation) | MKK6(h) + ATP --> MKK6(h){p} + ADP (phosphorylation) | MKK6(h) + ATP --TAK1(m.s.)--> MKK6(h){p} + ADP (phosphorylation) | MKK6(h) --> DEFB4(h) (transactivation) | MKK6(h) --> Beta-defensin2(h) (increase of secretion) | MEKK2(m) --> MKK6(h) (phosphorylation) | MEKK3(m) --> MKK6(h) (phosphorylation) | MKK6(h){p} --PP2Calpha2(h)--> MKK6(h) + p (dephosphorylation) | MAP2K6(h) --> MKK6(h) (expression). | HCV-NS5A(HCV) + ATP --MKK6(h)--> HCV-NS5A(HCV){p} + ADP (phosphorylation) |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 207 | O-acetylserine; by Yersinia yopJ;alternate. | Swiss-Prot 53.0 | 207 | Phosphoserine; alternate. | Swiss-Prot 53.0 | 211 | O-acetylthreonine; by Yersinia yopJ;alternate. | Swiss-Prot 53.0 | 211 | Phosphothreonine; alternate. | Swiss-Prot 53.0 | 207 | Phosphoserine | 8622669 | Phospho.ELM 6.0 | 211 | Phosphothreonine | 8622669 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 64920933 - 64922933 | GoldenGate_Methylation_Cancer_Panel_I |
chr17 |
Promoter: 64920933 - 64922933 | GSE27584 |