| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5608 |
Name | MAP2K6 |
Synonymous | mitogen-activated protein kinase kinase 6;MAP2K6;mitogen-activated protein kinase kinase 6 |
Definition | MAPK/ERK kinase 6|MAPKK 6|MEK 6|SAPK kinase 3|dual specificity mitogen-activated protein kinase kinase 6|protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)|stress-activated protein kinase kinase 3 |
Position | 17q24.3 |
Gene Type | protein-coding |
COSMIC somatic mutation [Top] | |||
Mutation (CDS; AA; Chr) | Site | Histology | Mutation Type |
|---|---|---|---|
c.663C>A; p.A221A; 17:69523641-69523641 |
skin | malignant_melanoma | Substitution - coding silent |
c.558C>T; p.L186L; 17:69523536-69523536 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.154G>A; p.D52N; 17:69517521-69517521 |
pancreas | carcinoma | Substitution - Missense |
c.405A>G; p.S135S; 17:69520308-69520308 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.114C>A; p.C38*; 17:69516885-69516885 |
central_nervous_system; brain | glioma | Substitution - Nonsense |
c.994C>A; p.L332I; 17:69541742-69541742 |
breast | carcinoma | Substitution - Missense |
c.694A>C; p.K232Q; 17:69524931-69524931 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.694A>C; p.K232Q; 17:69524931-69524931 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.694A>C; p.K232Q; 17:69524931-69524931 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.694A>C; p.K232Q; 17:69524931-69524931 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.694A>C; p.K232Q; 17:69524931-69524931 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.570C>T; p.L190L; 17:69523548-69523548 |
breast | carcinoma | Substitution - coding silent |
c.734T>G; p.I245S; 17:69524971-69524971 |
autonomic_ganglia | neuroblastoma | Substitution - Missense |
c.694A>C; p.K232Q; 17:69524931-69524931 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.694A>C; p.K232Q; 17:69524931-69524931 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.694A>C; p.K232Q; 17:69524931-69524931 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.488T>G; p.V163G; 17:69521053-69521053 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.671G>T; p.R224I; 17:69524908-69524908 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.413A>C; p.K138T; 17:69520316-69520316 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.342C>T; p.T114T; 17:69519408-69519408 |
skin | malignant_melanoma | Substitution - coding silent |
c.589G>A; p.D197N; 17:69523567-69523567 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.279G>T; p.Q93H; 17:69519345-69519345 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.154G>T; p.D52Y; 17:69517521-69517521 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.181C>T; p.R61*; 17:69517548-69517548 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.516G>A; p.K172K; 17:69521081-69521081 |
bone; tibia | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - coding silent |
c.651A>G; p.K217K; 17:69523629-69523629 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.100G>T; p.D34Y; 17:69516871-69516871 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.329C>T; p.P110L; 17:69519395-69519395 |
skin; axilla | malignant_melanoma | Substitution - Missense |
c.114C>T; p.C38C; 17:69516885-69516885 |
prostate | carcinoma; adenocarcinoma | Substitution - coding silent |
c.363G>T; p.R121R; 17:69519429-69519429 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.738G>T; p.T246T; 17:69524975-69524975 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.254G>C; p.R85P; 17:69519320-69519320 |
thyroid | carcinoma | Substitution - Missense |
c.248G>A; p.R83Q; 17:69519314-69519314 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.248G>A; p.R83Q; 17:69519314-69519314 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.938T>G; p.F313C; 17:69541686-69541686 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.41A>C; p.K14T; 17:69505804-69505804 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.351C>T; p.G117G; 17:69519417-69519417 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.323A>T; p.D108V; 17:69519389-69519389 |
prostate | carcinoma | Substitution - Missense |
c.295G>A; p.D99N; 17:69519361-69519361 |
skin | malignant_melanoma | Substitution - Missense |
c.874T>C; p.S292P; 17:69526702-69526702 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.11C>A; p.S4*; 17:69414995-69414995 |
pancreas | carcinoma | Substitution - Nonsense |
c.216C>T; p.H72H; 17:69517583-69517583 |
pancreas | carcinoma | Substitution - coding silent |
c.870delT; p.F290fs*6; 17:69526698-69526698 |
lung | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.213G>T; p.R71R; 17:69517580-69517580 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.245A>T; p.K82M; 17:69517612-69517612 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.217G>A; p.V73M; 17:69517584-69517584 |
ovary | other; neoplasm | Substitution - Missense |
c.462C>A; p.I154I; 17:69520365-69520365 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.254G>A; p.R85Q; 17:69519320-69519320 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.21G>A; p.K7K; 17:69505784-69505784 |
skin | malignant_melanoma | Substitution - coding silent |
c.26G>A; p.R9Q; 17:69505789-69505789 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.862G>C; p.V288L; 17:69526690-69526690 |
skin | malignant_melanoma | Substitution - Missense |
c.249G>T; p.R83R; 17:69519315-69519315 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.308C>T; p.S103F; 17:69519374-69519374 |
stomach | carcinoma | Substitution - Missense |
c.221C>T; p.P74L; 17:69517588-69517588 |
skin | malignant_melanoma | Substitution - Missense |
c.565G>T; p.A189S; 17:69523543-69523543 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.331T>A; p.F111I; 17:69519397-69519397 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.742-1G>A; p.?; 17:69526569-69526569 |
lung | carcinoma; adenocarcinoma | Unknown |
c.927+2T>C; p.?; 17:69536162-69536162 |
large_intestine; rectum | carcinoma; adenocarcinoma | Unknown |
c.892A>T; p.N298Y; 17:69536125-69536125 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.2T>G; p.M1R; 17:69414986-69414986 |
pancreas | NS | Substitution - Missense |
c.2T>G; p.M1R; 17:69414986-69414986 |
pancreas | carcinoma | Substitution - Missense |
c.91C>A; p.R31R; 17:69516862-69516862 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.91C>A; p.R31R; 17:69516862-69516862 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.825G>A; p.S275S; 17:69526653-69526653 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.12G>A; p.S4S; 17:69414996-69414996 |
skin | malignant_melanoma | Substitution - coding silent |
c.62A>T; p.E21V; 17:69505825-69505825 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.521C>T; p.S174F; 17:69521086-69521086 |
skin | malignant_melanoma | Substitution - Missense |
c.890A>C; p.K297T; 17:69536123-69536123 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.570C>A; p.L190L; 17:69523548-69523548 |
oesophagus; lower_third | carcinoma; adenocarcinoma | Substitution - coding silent |
c.629A>G; p.K210R; 17:69523607-69523607 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.89C>A; p.P30H; 17:69516860-69516860 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.550A>G; p.N184D; 17:69523528-69523528 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.761G>T; p.R254L; 17:69526589-69526589 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma; desmoplastic | Substitution - Missense |
c.24G>T; p.K8N; 17:69505787-69505787 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |