| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5598 |
Name | MAPK7 |
Synonymous | mitogen-activated protein kinase 7;MAPK7;mitogen-activated protein kinase 7 |
Definition | BMK-1|BMK1 kinase|ERK-5|MAP kinase 7|MAPK 7|big MAP kinase 1|extracellular signal-regulated kinase 5|extracellular-signal-regulated kinase 5 |
Position | 17p11.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | ERK5(h) + ATP --MKK5 alpha-1(r)--> ERK5(h){p} + ADP (phosphorylation) | PPARgamma(h) + ERK5(h) <==> PPARgamma(h):ERK5(h) (binding) | ERK5(h) + ATP --> ERK5(h){pY} + ADP (phosphorylation) | ERK5(h) + 2 ATP --> ERK5(h){pT219}{pY221} + 2 ADP (phosphorylation) | MKK5(h) + ERK5(h) <==> MKK5(h):ERK5(h) (binding) | RSK1(h) + ERK5(h) <==> RSK1(h):ERK5(h) (binding) | RSK2(h) + ERK5(h) <==> RSK2(h):ERK5(h) (binding) | ERK5(h) + ATP --> ERK5(h){p} + ADP (phosphorylation) | MAPK7(h) --> ERK5(h) (expression). | ERK5(h) + MEF-2DA0(r) <==> ERK5(h):MEF-2DA0(r) (binding) | ERK5(h) + MKK5(h) <==> ERK5(h):MKK5(h) (binding) | ERK5(h) + 3 ATP --> ERK5(h){pS}{pT}{pY} + 3 ADP (phosphorylation) | ERK5(h) + 2 ATP --MKK5-isoform1(h)--> ERK5(h){pT218}{pY220} + 2 ADP (phosphorylation) | ERK5(h) + 5 ATP --> ERK5(h){pS420}{pS432}{pS495}{pS730}{pT732} + 5 ADP (phosphorylation) | ERK5(h) + ATP --> ERK5(h){p} + ADP (phosphorylation) | RSK2(c) + ERK5(h) <==> RSK2(c):ERK5(h) (binding) | ERK5(h) + RSK1(h) <==> ERK5(h):RSK1(h) (binding) | MAPK7(h) --> ERK5(h) (expression). | MEF-2DA0(r) + ATP --ERK5(h)--> MEF-2DA0(r){p} + ADP (phosphorylation) | MEF-2C(m.s.) + ATP --ERK5(h)--> MEF-2C(m.s.){p} + ADP (phosphorylation) | MKK5-isoform1(h) + 4 ATP --ERK5(h)--> MKK5-isoform1(h){pS129}{pS137}{pS142}{pS149} + 4 ADP (phosphorylation) | RSK2(c) + ATP --ERK5(h)--> RSK2(c){p} + ADP (phosphorylation) | MAPK7(h) --> MAPK7_1(h) (expression). | hsa-miR-143 --/ MAPK7_1(h) (predicted) | hsa-miR-24 --/ MAPK7_1(h) (predicted) | MAPK7(h) --> MAPK7_2(h) (expression). | MAPK7(h) --> MAPK7_3(h) (expression). | MAPK7(h) --> MAPK7_4(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 218 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 220 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 218 | Phosphothreonine | 11739740 | Phospho.ELM 6.0 | 220 | Phosphotyrosine | 11739740 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 19220900 - 19222900 | Agilent_014791 |
chr17 |
Promoter: 19220159 - 19222159 | Agilent_014791 |
chr17 |
Promoter: 19220900 - 19222900 | GSE27584 |
chr17 |
Promoter: 19220900 - 19222900 | GSE27584 |
chr17 |
Promoter: 19220159 - 19222159 | GSE27584 |
chr17 |
Promoter: 19220159 - 19222159 | GSE27584 |
chr17 |
Promoter: 19220900 - 19222900 | Agilent_014791_44K |
chr17 |
Promoter: 19220159 - 19222159 | Agilent_014791_44K |
chr17 |
Promoter: 19220159 - 19222159 | Agilent_014791_44K |
chr17 |
Promoter: 19220900 - 19222900 | Agilent_014791_44K |