Entrez Gene

Basic Information
Gene ID	5598
Name	MAPK7
Synonymous	mitogen-activated protein kinase 7;MAPK7;mitogen-activated protein kinase 7
Definition	BMK-1\|BMK1 kinase\|ERK-5\|MAP kinase 7\|MAPK 7\|big MAP kinase 1\|extracellular signal-regulated kinase 5\|extracellular-signal-regulated kinase 5
Position	17p11.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.136G>A; p.D46N; 17:19379036-19379036	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2287C>T; p.P763S; 17:19382936-19382936	skin	malignant_melanoma	Substitution - Missense
c.378C>T; p.P126P; 17:19379927-19379927	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.61G>T; p.V21L; 17:19378961-19378961	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2183C>A; p.P728H; 17:19382832-19382832	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2183C>A; p.P728H; 17:19382832-19382832	large_intestine; colon	carcinoma	Substitution - Missense
c.2183C>A; p.P728H; 17:19382832-19382832	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.83C>T; p.T28I; 17:19378983-19378983	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.953G>C; p.R318P; 17:19381162-19381162	kidney	other; neoplasm	Substitution - Missense
c.805C>A; p.H269N; 17:19381014-19381014	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1908T>C; p.P636P; 17:19382211-19382211	thyroid	other; neoplasm	Substitution - coding silent
c.948C>T; p.A316A; 17:19381157-19381157	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1313C>T; p.P438L; 17:19381522-19381522	breast	carcinoma	Substitution - Missense
c.1000G>A; p.A334T; 17:19381209-19381209	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2054_2057delCTTA; p.Y686fs*27; 17:19382357-19382360	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - Frameshift
c.884G>T; p.R295L; 17:19381093-19381093	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1289C>T; p.A430V; 17:19381498-19381498	skin	malignant_melanoma	Substitution - Missense
c.775C>T; p.R259C; 17:19380984-19380984	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.775C>T; p.R259C; 17:19380984-19380984	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1105C>T; p.R369C; 17:19381314-19381314	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.565T>C; p.L189L; 17:19380774-19380774	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.540C>T; p.H180H; 17:19380749-19380749	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.787C>A; p.P263T; 17:19380996-19380996	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.383G>A; p.G128D; 17:19379932-19379932	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.257T>C; p.I86T; 17:19379806-19379806	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.737_738GG>AA; p.W246*; 17:19380946-19380947	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>T; p.A338V; 17:19381222-19381222	central_nervous_system; brain	glioma	Substitution - Missense
c.1159G>A; p.D387N; 17:19381368-19381368	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1884A>C; p.V628V; 17:19382187-19382187	thyroid	other; neoplasm	Substitution - coding silent
c.1213C>T; p.L405L; 17:19381422-19381422	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2089G>A; p.G697R; 17:19382392-19382392	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2425G>A; p.D809N; 17:19383205-19383205	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1537C>T; p.R513C; 17:19381840-19381840	skin	malignant_melanoma	Substitution - Missense
c.1258C>T; p.P420S; 17:19381467-19381467	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.346G>A; p.A116T; 17:19379895-19379895	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1836G>A; p.Q612Q; 17:19382139-19382139	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.548T>C; p.L183P; 17:19380757-19380757	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.503G>A; p.R168Q; 17:19380712-19380712	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1491A>C; p.A497A; 17:19381794-19381794	ovary	other; neoplasm	Substitution - coding silent
c.715T>C; p.Y239H; 17:19380924-19380924	breast	carcinoma	Substitution - Missense
c.2149C>A; p.L717I; 17:19382452-19382452	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1649G>A; p.G550D; 17:19381952-19381952	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.15G>C; p.L5L; 17:19378915-19378915	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.194C>T; p.A65V; 17:19379094-19379094	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2198C>T; p.T733I; 17:19382847-19382847	skin; trunk	malignant_melanoma	Substitution - Missense
c.361C>T; p.L121L; 17:19379910-19379910	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.430C>G; p.L144V; 17:19380639-19380639	central_nervous_system; brain	glioma	Substitution - Missense
c.977G>A; p.R326H; 17:19381186-19381186	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.977G>A; p.R326H; 17:19381186-19381186	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2312_2313insCG; p.S772fs*17; 17:19383092-19383093	endometrium	carcinoma; endometrioid_carcinoma	Insertion - Frameshift
c.977G>A; p.R326H; 17:19381186-19381186	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.542G>A; p.R181H; 17:19380751-19380751	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.883C>A; p.R295R; 17:19381092-19381092	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2434G>T; p.D812Y; 17:19383214-19383214	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1004G>A; p.R335H; 17:19381213-19381213	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.631C>T; p.P211S; 17:19380840-19380840	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2249T>C; p.F750S; 17:19382898-19382898	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.318C>G; p.L106L; 17:19379867-19379867	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1628G>A; p.R543Q; 17:19381931-19381931	thyroid	other; neoplasm	Substitution - Missense
c.1038C>T; p.F346F; 17:19381247-19381247	skin	malignant_melanoma	Substitution - coding silent
c.1770C>T; p.A590A; 17:19382073-19382073	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.487C>A; p.L163M; 17:19380696-19380696	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2417T>G; p.L806R; 17:19383197-19383197	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1953C>T; p.V651V; 17:19382256-19382256	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1328G>T; p.G443V; 17:19381537-19381537	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1024C>T; p.L342F; 17:19381233-19381233	skin	malignant_melanoma	Substitution - Missense
c.1931G>T; p.G644V; 17:19382234-19382234	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1450C>T; p.L484F; 17:19381659-19381659	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.986G>A; p.R329H; 17:19381195-19381195	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.177G>T; p.E59D; 17:19379077-19379077	kidney	other; neoplasm	Substitution - Missense
c.1864G>A; p.G622S; 17:19382167-19382167	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2324C>A; p.A775D; 17:19383104-19383104	thyroid	other; neoplasm	Substitution - Missense
c.712G>C; p.E238Q; 17:19380921-19380921	oesophagus	carcinoma	Substitution - Missense
c.1766C>G; p.P589R; 17:19382069-19382069	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1544G>T; p.R515L; 17:19381847-19381847	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1984A>G; p.S662G; 17:19382287-19382287	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1502C>A; p.A501D; 17:19381805-19381805	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1502C>A; p.A501D; 17:19381805-19381805	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1502C>A; p.A501D; 17:19381805-19381805	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1502C>A; p.A501D; 17:19381805-19381805	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.150C>T; p.D50D; 17:19379050-19379050	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.764T>G; p.M255R; 17:19380973-19380973	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.668C>T; p.A223V; 17:19380877-19380877	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.922C>T; p.P308S; 17:19381131-19381131	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1956delC; p.A653fs*61; 17:19382259-19382259	central_nervous_system; medulla	primitive_neuroectodermal_tumour-medulloblastoma; classic	Deletion - Frameshift
c.2410C>T; p.P804S; 17:19383190-19383190	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.558C>T; p.S186S; 17:19380767-19380767	skin	malignant_melanoma	Substitution - coding silent
c.431T>C; p.L144P; 17:19380640-19380640	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1175G>A; p.R392H; 17:19381384-19381384	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1430C>A; p.A477D; 17:19381639-19381639	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1813C>T; p.P605S; 17:19382116-19382116	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1735G>A; p.A579T; 17:19382038-19382038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.270C>T; p.F90F; 17:19379819-19379819	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1754C>G; p.S585C; 17:19382057-19382057	pancreas	carcinoma	Substitution - Missense
c.774G>A; p.R258R; 17:19380983-19380983	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2413A>G; p.M805V; 17:19383193-19383193	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1895C>T; p.A632V; 17:19382198-19382198	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.783C>G; p.L261L; 17:19380992-19380992	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.614G>C; p.R205P; 17:19380823-19380823	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2408C>T; p.S803F; 17:19383188-19383188	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1056T>C; p.D352D; 17:19381265-19381265	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2357G>A; p.G786D; 17:19383137-19383137	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.333C>T; p.H111H; 17:19379882-19379882	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1331C>T; p.P444L; 17:19381540-19381540	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2408C>A; p.S803Y; 17:19383188-19383188	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2365C>T; p.P789S; 17:19383145-19383145	skin	malignant_melanoma	Substitution - Missense
c.2087C>T; p.A696V; 17:19382390-19382390	skin	malignant_melanoma	Substitution - Missense
c.683G>A; p.R228H; 17:19380892-19380892	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.865G>T; p.V289L; 17:19381074-19381074	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.293G>A; p.R98Q; 17:19379842-19379842	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1630G>T; p.G544W; 17:19381933-19381933	thyroid	other; neoplasm	Substitution - Missense
c.2213G>A; p.G738E; 17:19382862-19382862	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1765C>T; p.P589S; 17:19382068-19382068	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.687G>A; p.A229A; 17:19380896-19380896	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.863C>A; p.A288D; 17:19381072-19381072	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1174C>T; p.R392C; 17:19381383-19381383	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.671C>T; p.T224M; 17:19380880-19380880	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.671C>T; p.T224M; 17:19380880-19380880	breast	carcinoma	Substitution - Missense
c.976C>T; p.R326C; 17:19381185-19381185	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1293G>A; p.M431I; 17:19381502-19381502	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2274C>T; p.G758G; 17:19382923-19382923	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.334G>A; p.D112N; 17:19379883-19379883	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1489G>A; p.A497T; 17:19381792-19381792	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1591C>T; p.R531W; 17:19381894-19381894	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1920C>T; p.P640P; 17:19382223-19382223	skin	malignant_melanoma	Substitution - coding silent
c.66_67GG>AA; p.A23T; 17:19378966-19378967	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1106G>A; p.R369H; 17:19381315-19381315	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1781C>T; p.T594M; 17:19382084-19382084	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1187G>T; p.R396L; 17:19381396-19381396	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1627C>T; p.R543W; 17:19381930-19381930	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1627C>T; p.R543W; 17:19381930-19381930	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1523T>C; p.V508A; 17:19381826-19381826	breast	carcinoma	Substitution - Missense
c.1957G>A; p.A653T; 17:19382260-19382260	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2167G>A; p.E723K; 17:19382816-19382816	stomach	carcinoma	Substitution - Missense
c.1341C>T; p.D447D; 17:19381550-19381550	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1772C>T; p.P591L; 17:19382075-19382075	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.313A>G; p.I105V; 17:19379862-19379862	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.315C>T; p.I105I; 17:19379864-19379864	skin	malignant_melanoma	Substitution - coding silent
c.315C>T; p.I105I; 17:19379864-19379864	skin	malignant_melanoma	Substitution - coding silent
c.2153C>T; p.S718F; 17:19382456-19382456	prostate	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]