| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 51588 |
Name | PIAS4 |
Synonymous | protein inhibitor of activated STAT, 4;PIAS4;protein inhibitor of activated STAT, 4 |
Definition | E3 SUMO-protein ligase PIAS4|protein inhibitor of activated STAT protein 4|protein inhibitor of activated STAT protein PIASy|protein inhibitor of activated STAT protein gamma|zinc finger, MIZ-type containing 6 |
Position | 19p13.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | PIASy(h) + sumo3(h) <==> PIASy(h):sumo3(h) (binding) | PIASy(h) + SUMO2(h) <==> PIASy(h):SUMO2(h) (binding) | PIASy(h) + sumo3(h) <==> PIASy(h):sumo3(h) (binding) | PIASy(h) + ADA3(h) <==> PIASy(h):ADA3(h) (binding) | AR-isoform1(h) + PIASy(h) <==> AR-isoform1(h):PIASy(h) (binding) | HDAC1(m.s.) + PIASy(h) <==> HDAC1(m.s.):PIASy(h) (binding) | hdac2(m.s.) + PIASy(h) <==> hdac2(m.s.):PIASy(h) (binding) | PIASy(h) + c-Ets-1(m) <==> PIASy(h):c-Ets-1(m) (binding) | PIASy(h) + IKK-gamma(h) <==> PIASy(h):IKK-gamma(h) (binding) | IKK-gamma(h) + PIASy(h) <==> IKK-gamma(h):PIASy(h) (binding) | Smad2(m.s.) + PIASy(h) <==> Smad2(m.s.):PIASy(h) (binding) | Smad3(m.s.) + PIASy(h) <==> Smad3(m.s.):PIASy(h) (binding) | Smad4(m.s.) + PIASy(h) <==> Smad4(m.s.):PIASy(h) (binding) | Smad6(m.s.) + PIASy(h) <==> Smad6(m.s.):PIASy(h) (binding) | Smad7(m.s.) + PIASy(h) <==> Smad7(m.s.):PIASy(h) (binding) | RFP-alpha(h) + PIASy(h) <==> RFP-alpha(h):PIASy(h) (binding) | RFP(h) + PIASy(h) <==> RFP(h):PIASy(h) (binding) | p73alpha(h) + PIASy(h) <==> p73alpha(h):PIASy(h) (binding) | p53(h) + PIASy(h) <==> p53(h):PIASy(h) (binding) | PIAS4(h) --> PIASy(h) (expression). | IKK-gamma(h) + sumo1(h) --PIASy(h),Ubc9(h)--> IKK-gamma(h){sumo} (sumoylation) | PSF(h) + sumo1(h) --PIASy(h)--> PSF(h){sumoK338} (sumoylation) | RFP(h) + sumo1(m.s.) --PIASy(h)--> RFP(h){sumo} (sumoylation) | MR-isoform1(h) + sumo1(h) --Aos1(m.s.):SAE2(m.s.),Ubc9(m.s.),PIASy(h)--> MR-isoform1(h){sumo} (sumoylation) | BARD1(h) + PIASy(h) <==> BARD1(h):PIASy(h) (binding) | PIASy(h) + CA150(h) <==> PIASy(h):CA150(h) (binding) | PIASy(h) + GADD45-gamma(h) <==> PIASy(h):GADD45-gamma(h) (binding) | ADA3(h) + PIASy(h) <==> ADA3(h):PIASy(h) (binding) | HYPA(h) + PIASy(h) <==> HYPA(h):PIASy(h) (binding) | Mi2-alpha(h) + PIASy(h) <==> Mi2-alpha(h):PIASy(h) (binding) | p53(m) + PIASy(h) <==> p53(m):PIASy(h) (binding) | zhx1(h) + PIASy(h) <==> zhx1(h):PIASy(h) (binding) | IMMT(h) + PIASy(h) <==> IMMT(h):PIASy(h) (binding) | importin-beta1(h) + PIASy(h) <==> importin-beta1(h):PIASy(h) (binding) | NFL(h) + PIASy(h) <==> NFL(h):PIASy(h) (binding) | PTN(h) + PIASy(h) <==> PTN(h):PIASy(h) (binding) | vimentin(h) + PIASy(h) <==> vimentin(h):PIASy(h) (binding) | PIASy(h) + CLK1(h) <==> PIASy(h):CLK1(h) (binding) | PIASy(h) + IMPDH2(h) <==> PIASy(h):IMPDH2(h) (binding) | MAGEH1(h) + PIASy(h) <==> MAGEH1(h):PIASy(h) (binding) | sumo3(h) + PIASy(h) <==> sumo3(h):PIASy(h) (binding) | PIASy(h) --> IL8(h) (transactivation) | PIASy(h) --> CDKN1A(h) (transactivation) | PIASy(h) --> NFKBIA(h) (transactivation) | RFP-alpha(h) + PIASy(h) <==> RFP-alpha(h):PIASy(h) (binding) | NDP52(h) + PIASy(h) <==> NDP52(h):PIASy(h) (binding) | PIASy(h) --> brca1(h){sumo2} (increase of sumoylation) | PIASy(h) --> brca1(h){sumo} (increase of sumoylation) | PIASy(h) --> 53BP1-isoform1(h){sumo} (increase of sumoylation) | PIASy(h) --> brca1(m.s.){sumo2} (increase of sumoylation) | PIASy(h) --> RPA2(h){pS4}{pS8} (increase of phosphorylation) | PIAS4(h) --> PIASy(h) (expression). |
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Post Transcriptional Modification [Top] | |||
There is no record for PIAS4 | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr19 |
Promoter: 3957249 - 3959249 | Agilent_014791 |
chr19 |
Promoter: 3957249 - 3959249 | GSE27584 |
chr19 |
Promoter: 3957249 - 3959249 | Agilent_014791_44K |