Entrez Gene

Basic Information
Gene ID	51588
Name	PIAS4
Synonymous	protein inhibitor of activated STAT, 4;PIAS4;protein inhibitor of activated STAT, 4
Definition	E3 SUMO-protein ligase PIAS4\|protein inhibitor of activated STAT protein 4\|protein inhibitor of activated STAT protein PIASy\|protein inhibitor of activated STAT protein gamma\|zinc finger, MIZ-type containing 6
Position	19p13.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.352G>A; p.G118R; 19:4013247-4013247	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.738C>T; p.T246T; 19:4028785-4028785	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.711G>C; p.K237N; 19:4028758-4028758	urinary_tract; bladder	carcinoma	Substitution - Missense
c.326C>T; p.P109L; 19:4013221-4013221	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.887C>T; p.P296L; 19:4029016-4029016	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1141G>A; p.G381R; 19:4033579-4033579	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.512G>T; p.R171I; 19:4024093-4024093	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.473A>C; p.K158T; 19:4024054-4024054	skin	malignant_melanoma	Substitution - Missense
c.84C>T; p.G28G; 19:4012979-4012979	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.123G>T; p.R41S; 19:4013018-4013018	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1317C>T; p.N439N; 19:4037659-4037659	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1183G>A; p.E395K; 19:4037414-4037414	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1180G>A; p.D394N; 19:4037411-4037411	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1174G>T; p.D392Y; 19:4037405-4037405	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.829C>T; p.R277W; 19:4028958-4028958	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.829C>T; p.R277W; 19:4028958-4028958	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.829C>T; p.R277W; 19:4028958-4028958	large_intestine; colon	carcinoma	Substitution - Missense
c.829C>T; p.R277W; 19:4028958-4028958	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.693G>C; p.K231N; 19:4028740-4028740	breast	carcinoma	Substitution - Missense
c.265A>G; p.T89A; 19:4013160-4013160	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.573C>T; p.V191V; 19:4028179-4028179	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.265A>G; p.T89A; 19:4013160-4013160	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.47G>A; p.R16Q; 19:4012942-4012942	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.874G>A; p.G292R; 19:4029003-4029003	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1152G>A; p.S384S; 19:4037383-4037383	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.429T>C; p.D143D; 19:4013324-4013324	breast	carcinoma	Substitution - coding silent
c.429T>C; p.D143D; 19:4013324-4013324	thyroid	other; neoplasm	Substitution - coding silent
c.286G>A; p.V96M; 19:4013181-4013181	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.179A>C; p.E60A; 19:4013074-4013074	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1101G>A; p.V367V; 19:4033539-4033539	breast	carcinoma	Substitution - coding silent
c.1356G>A; p.P452P; 19:4037698-4037698	thyroid	carcinoma; anaplastic_carcinoma	Substitution - coding silent
c.100C>G; p.L34V; 19:4012995-4012995	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.370G>A; p.A124T; 19:4013265-4013265	breast	carcinoma	Substitution - Missense
c.231G>A; p.P77P; 19:4013126-4013126	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1225G>A; p.A409T; 19:4037456-4037456	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.665C>T; p.S222F; 19:4028593-4028593	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.665C>T; p.S222F; 19:4028593-4028593	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.411G>T; p.P137P; 19:4013306-4013306	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.646G>A; p.V216I; 19:4028574-4028574	skin	malignant_melanoma	Substitution - Missense
c.932C>T; p.P311L; 19:4033124-4033124	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.411G>A; p.P137P; 19:4013306-4013306	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1227C>T; p.A409A; 19:4037458-4037458	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.33G>A; p.M11I; 19:4012928-4012928	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.114C>A; p.L38L; 19:4013009-4013009	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.888G>A; p.P296P; 19:4029017-4029017	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.744C>T; p.L248L; 19:4028791-4028791	breast	carcinoma	Substitution - coding silent
c.605G>A; p.C202Y; 19:4028533-4028533	large_intestine; colon	carcinoma	Substitution - Missense
c.605G>A; p.C202Y; 19:4028533-4028533	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1013_1014GG>AA; p.R338Q; 19:4033451-4033452	skin; trunk	malignant_melanoma	Substitution - Missense
c.743T>C; p.L248P; 19:4028790-4028790	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.274C>T; p.R92W; 19:4013169-4013169	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.123G>A; p.R41R; 19:4013018-4013018	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.328G>A; p.V110M; 19:4013223-4013223	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1250C>T; p.P417L; 19:4037481-4037481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.300G>A; p.P100P; 19:4013195-4013195	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1422G>A; p.S474S; 19:4037764-4037764	liver	carcinoma	Substitution - coding silent
c.1422G>A; p.S474S; 19:4037764-4037764	liver	carcinoma	Substitution - coding silent
c.599C>G; p.T200S; 19:4028527-4028527	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.47G>T; p.R16L; 19:4012942-4012942	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1218G>A; p.P406P; 19:4037449-4037449	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.666C>T; p.S222S; 19:4028594-4028594	skin; leg	malignant_melanoma	Substitution - coding silent
c.194G>A; p.R65H; 19:4013089-4013089	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.469G>T; p.E157*; 19:4024050-4024050	pancreas	NS	Substitution - Nonsense
c.469G>T; p.E157*; 19:4024050-4024050	pancreas	carcinoma	Substitution - Nonsense
c.483G>A; p.E161E; 19:4024064-4024064	skin	malignant_melanoma	Substitution - coding silent
c.1318G>A; p.G440R; 19:4037660-4037660	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.376A>C; p.T126P; 19:4013271-4013271	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.855G>A; p.L285L; 19:4028984-4028984	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1179C>T; p.A393A; 19:4037410-4037410	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1355C>T; p.P452L; 19:4037697-4037697	breast	carcinoma	Substitution - Missense
c.1056C>T; p.F352F; 19:4033494-4033494	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.455T>C; p.V152A; 19:4024036-4024036	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.193C>T; p.R65C; 19:4013088-4013088	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.520G>C; p.E174Q; 19:4024101-4024101	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1311C>T; p.S437S; 19:4037653-4037653	pancreas	carcinoma	Substitution - coding silent
c.288G>T; p.V96V; 19:4013183-4013183	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.46C>T; p.R16*; 19:4012941-4012941	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1434T>G; p.D478E; 19:4037776-4037776	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.46C>T; p.R16*; 19:4012941-4012941	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1365C>A; p.S455R; 19:4037707-4037707	thyroid	other; neoplasm	Substitution - Missense
c.106C>G; p.H36D; 19:4013001-4013001	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.280G>T; p.G94C; 19:4013175-4013175	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1284C>T; p.D428D; 19:4037626-4037626	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1274-4G>A; p.?; 19:4037612-4037612	kidney	other; neoplasm	Unknown
c.8C>T; p.A3V; 19:4007768-4007768	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.552C>A; p.P184P; 19:4028158-4028158	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.801+8C>T; p.?; 19:4028856-4028856	pancreas	carcinoma	Unknown
c.528C>T; p.I176I; 19:4024109-4024109	skin	malignant_melanoma	Substitution - coding silent
c.1254G>T; p.Q418H; 19:4037485-4037485	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1287C>T; p.A429A; 19:4037629-4037629	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]