Entrez Gene

Basic Information
Gene ID	5111
Name	PCNA
Synonymous	proliferating cell nuclear antigen;PCNA;proliferating cell nuclear antigen
Definition	DNA polymerase delta auxiliary protein\|cyclin
Position	20pter-p12
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
PCNA(h) + p21Cip1(h) <==> PCNA(h):p21Cip1(h) (binding)
Mcl-1(m.s.) + PCNA(h) <==> Mcl-1(m.s.):PCNA(h) (binding)
Mcl-1(h) + PCNA(h) <==> Mcl-1(h):PCNA(h) (binding)
PCNA(h) --> DNA polymerase subunit gamma 1(r) (activation)
XPG(h) + PCNA(h) <==> XPG(h):PCNA(h) (binding)
PCNA(h) + Pol-eta(h) <==> PCNA(h):Pol-eta(h) (binding)
PCNA(h) + POLL(h) <==> PCNA(h):POLL(h) (binding)
PCNA(h) + Polk(h) <==> PCNA(h):Polk(h) (binding)
PCNA(h) + FEN1(h) <==> PCNA(h):FEN1(h) (binding)
3 PCNA(h) <==> (PCNA(h))3 (oligomerization)
HDAC1(h) + PCNA(h) <==> HDAC1(h):PCNA(h) (binding)
PCNA(h) + HDAC1(m.s.) <==> PCNA(h):HDAC1(m.s.) (binding)
NTH1(h) + PCNA(h) <==> NTH1(h):PCNA(h) (binding)
PCNA(h) + NR1B1-isoform1(h) <==> PCNA(h):NR1B1-isoform1(h) (binding)
PCNA(h) + NR1B1(h) <==> PCNA(h):NR1B1(h) (binding)
PCNA(h) + PDIP38(h) <==> PCNA(h):PDIP38(h) (binding)
PCNA(h) + PARP(h) <==> PCNA(h):PARP(h) (binding)
PCNA(h) + MYH(h) <==> PCNA(h):MYH(h) (binding)
PCNA(h) + MYH-alpha3(h) <==> PCNA(h):MYH-alpha3(h) (binding)
PCNA(h) + MSH2(h) <==> PCNA(h):MSH2(h) (binding)
PCNA(h) + PMS2(h) <==> PCNA(h):PMS2(h) (binding)
PCNA(h) + WS(h) <==> PCNA(h):WS(h) (binding)
PCNA(h) + YB-1(h) <==> PCNA(h):YB-1(h) (binding)
PCNA(h) + YB-1(h) <==> PCNA(h):YB-1(h) (binding)
PCNA(h) + ubiquitin(h) --> PCNA(h){ub} (ubiquitination)
PCNA(h) + Pold1(h):Pold2(h):Pold3(h) <==> PCNA(h):Pold1(h):Pold2(h):Pold3(h) (binding)
PCNA(h) + APE2(h) <==> PCNA(h):APE2(h) (binding)
PCNA(h) + UDG-isoform2(h) <==> PCNA(h):UDG-isoform2(h) (binding)
PCNA(h) + p21Cip1(h) <==> PCNA(h):p21Cip1(h) (binding)
PCNA(h) + UDG-isoform2(m) <==> PCNA(h):UDG-isoform2(m) (binding)
PCNA(h) + UDG2(h) <==> PCNA(h):UDG2(h) (binding)
PCNA(h) + Polk(m.s.) <==> PCNA(h):Polk(m.s.) (binding)
PCNA(h) + Pol-eta(m.s.) <==> PCNA(h):Pol-eta(m.s.) (binding)
UDG-isoform2(h) + PCNA(h) + Pold(h) <==> UDG-isoform2(h):PCNA(h):Pold(h) (binding)
PCNA(h) + Ref-1(h) <==> PCNA(h):Ref-1(h) (binding)
PCNA(h) + MGMT(h) <==> PCNA(h):MGMT(h) (binding)
PCNA(h) + MPG(h) <==> PCNA(h):MPG(h) (binding)
PCNA(h) + Ref-1(h) <==> PCNA(h):Ref-1(h) (binding)
PCNA(h) + MPG(h) <==> PCNA(h):MPG(h) (binding)
PCNA(h) + CTF18(h) <==> PCNA(h):CTF18(h) (binding)
PCNA(h) + RFC3(h) <==> PCNA(h):RFC3(h) (binding)
p300(h) + PCNA(h) <==> p300(h):PCNA(h) (binding)
GADD45-alpha(h) + PCNA(h) <==> GADD45-alpha(h):PCNA(h) (binding)
p300(h) + PCNA(h) <==> p300(h):PCNA(h) (binding)
SET8(h) + PCNA(h) <==> SET8(h):PCNA(h) (binding)
PCNA(h) --> PCNA(h) (expression).
MBD1(h) --> PCNA(h) (binding)
CHAF1A(h) --> PCNA(h) (binding)
c-Jun(h) --> PCNA(h) (increase of abundance)
p75NTR(m.s.) --/ PCNA(h) (decrease of abundance)
MATH1(m.s.) --> PCNA(h) (increase of abundance)
DNTT(h) + PCNA(h) <==> DNTT(h):PCNA(h) (binding)
NTH1(h) + PCNA(h) <==> NTH1(h):PCNA(h) (binding)
PCNA(h) + PDIP38(h) <==> PCNA(h):PDIP38(h) (binding)
PCNA(h) + Dnmt1(h) <==> PCNA(h):Dnmt1(h) (binding)
PCNA(h) + Dnmt1-L(m) <==> PCNA(h):Dnmt1-L(m) (binding)
PCNA(h) + MYH-alpha3(h) <==> PCNA(h):MYH-alpha3(h) (binding)
PCNA(h) + Polb(h) <==> PCNA(h):Polb(h) (binding)
PCNA(h) + Polb(r) <==> PCNA(h):Polb(r) (binding)
PCNA(h) + Msh3(h) <==> PCNA(h):Msh3(h) (binding)
PCNA(h) + GTBP(h) <==> PCNA(h):GTBP(h) (binding)
PCNA(h) + FEN1(h) <==> PCNA(h):FEN1(h) (binding)
PCNA(h) + DNA-ligase1(h) <==> PCNA(h):DNA-ligase1(h) (binding)
PCNA(h) + Poli(h) <==> PCNA(h):Poli(h) (binding)
PCNA(h) + YB-1(h) <==> PCNA(h):YB-1(h) (binding)
PCNA(h) + YB-1(h) <==> PCNA(h):YB-1(h) (binding)
PCNA(h) + ubiquitin(h) --Rad-18(h),HR6B(h),E1(m.s.)--> PCNA(h){ub} (ubiquitination)
PCNA(h) + Pol-eta-isoform1(h) <==> PCNA(h):Pol-eta-isoform1(h) (binding)
APE2(h) + PCNA(h) <==> APE2(h):PCNA(h) (binding)
PCNA(h) + UDG-isoform2(h) <==> PCNA(h):UDG-isoform2(h) (binding)
PCNA(h) + UDG2(h) <==> PCNA(h):UDG2(h) (binding)
PCNA(h) + MPG(h) <==> PCNA(h):MPG(h) (binding)
PCNA(h) + Pold1(h) <==> PCNA(h):Pold1(h) (binding)
PCNA(h) + Pold2(h) <==> PCNA(h):Pold2(h) (binding)
PCNA(h) + Pold3(h) <==> PCNA(h):Pold3(h) (binding)
PCNA(h) + POLE1(h) <==> PCNA(h):POLE1(h) (binding)
PCNA(h) + RECC1-isoform2(h) <==> PCNA(h):RECC1-isoform2(h) (binding)
PCNA(h) + RFC3(h) <==> PCNA(h):RFC3(h) (binding)
PCNA(h) + RFC4(h) <==> PCNA(h):RFC4(h) (binding)
PCNA(h) + RFC5(h) <==> PCNA(h):RFC5(h) (binding)
PCNA(h) + RFC2-1(h) <==> PCNA(h):RFC2-1(h) (binding)
PCNA(h) + RFC2-2(h) <==> PCNA(h):RFC2-2(h) (binding)
PCNA(h) + MSH-2(h) <==> PCNA(h):MSH-2(h) (binding)
PCNA(h) + GTBP-N(h) <==> PCNA(h):GTBP-N(h) (binding)
PCNA(h) + Msh3(h) <==> PCNA(h):Msh3(h) (binding)
PCNA(h) + UDG-isoform1(h) <==> PCNA(h):UDG-isoform1(h) (binding)
PCNA(h) + Dnmt1-1(h) <==> PCNA(h):Dnmt1-1(h) (binding)
PCNA(h) + CTF18(h) <==> PCNA(h):CTF18(h) (binding)
PCNA(h) + DNA-PKcs-isoform1(h) <==> PCNA(h):DNA-PKcs-isoform1(h) (binding)
PCNA(h) + Ku70(h) <==> PCNA(h):Ku70(h) (binding)
PCNA(h) + Ku80(h) <==> PCNA(h):Ku80(h) (binding)
PCNA(h) + RHA(h) <==> PCNA(h):RHA(h) (binding)
PCNA(h) + p160MBP-1(h) <==> PCNA(h):p160MBP-1(h) (binding)
PCNA(h) + RPA1(h) <==> PCNA(h):RPA1(h) (binding)
PCNA(h) + RECC1(m.s.) + RFC2(m.s.) + RFC3(m.s.) + RFC4(m.s.) + RFC5(m.s.) <==> PCNA(h):RECC1(m.s.):RFC2(m.s.):RFC3(m.s.):RFC4(m.s.):RFC5(m.s.) (binding)
PCNA(h) + CTF18(h) + RFC2(m.s.) + RFC3(m.s.) + RFC4(m.s.) + RFC5(m.s.) <==> PCNA(h):CTF18(h):RFC2(m.s.):RFC3(m.s.):RFC4(m.s.):RFC5(m.s.) (binding)
p300(m.s.) + PCNA(h) <==> p300(m.s.):PCNA(h) (binding)
PCNA(h) + FEN1(h){ace} <==> PCNA(h):FEN1(h){ace} (binding)
PCNA(h) --> PCNA(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
164	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin).		Swiss-Prot 53.0

Chromosome	Location	Source
Methylation Profile [Top]
chr20	Promoter: 5048147 - 5050147	Agilent_014791
chr20	Promoter: 5048147 - 5050147	GSE27584
chr20	Promoter: 5054768 - 5056768	GSE27584
chr20	Promoter: 5054768 - 5056768	Agilent_014791_44K
chr20	Promoter: 5048147 - 5050147	Agilent_014791_44K
chr20	Promoter: 5054768 - 5056768	Agilent_014791
chr20	Promoter: 5048147 - 5050147	Agilent_014791

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]