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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

5111

Name

PCNA

Synonymous

proliferating cell nuclear antigen;PCNA;proliferating cell nuclear antigen

Definition

DNA polymerase delta auxiliary protein|cyclin

Position

20pter-p12

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 BARD1NCI_NATURE;

in same component

 BRCA1NCI_NATURE;

in same component

 DNA2REACTOME;

in same component

 ESR1NCI_NATURE;

in same component

 FEN1REACTOME;

in same component

 POLA1REACTOME;

in same component

 POLA2REACTOME;

in same component

 POLD1REACTOME;

in same component

 POLD2REACTOME;

in same component

 POLD3REACTOME;

in same component

 POLD4REACTOME;

in same component

 PRIM1REACTOME;

in same component

 PRIM2REACTOME;

in same component

 RAD51NCI_NATURE;

in same component

 RFC1REACTOME;

in same component

 RFC2REACTOME;

in same component

 RFC3REACTOME;

in same component

 RFC4REACTOME;

in same component

 RFC5REACTOME;

in same component

 RPA1REACTOME;

in same component

 RPA2REACTOME;

in same component

 RPA3REACTOME;

interacts with

 AIREBIOGRID;

interacts with

 ALDOAMINT;

interacts with

 ANXA2BIOGRID;

interacts with

 ANXA2MINT;

interacts with

 APEX1BIOGRID;

interacts with

 APEX2BIOGRID;

interacts with

 APEX2HPRD;

interacts with

 ARHGEF4MINT;

interacts with

 ATAD5BIOGRID;

interacts with

 BAZ1BBIOGRID;

interacts with

 BAZ1BHPRD;

interacts with

 CA2MINT;

interacts with

 CCL2BIOGRID;

interacts with

 CCNA2BIOGRID;

interacts with

 CCNB1HPRD;

interacts with

 CCND1BIOGRID;

interacts with

 CCND1HPRD;

interacts with

 CCND3BIOGRID;

interacts with

 CCND3HPRD;

interacts with

 CCNOBIOGRID;

interacts with

 CCNOHPRD;

interacts with

 CDC25CBIOGRID;

interacts with

 CDC25CHPRD;

interacts with

 CDC6BIOGRID;

interacts with

 CDC6HPRD;

interacts with

 CDK2BIOGRID;

interacts with

 CDK2HPRD;

interacts with

 CDK4BIOGRID;

interacts with

 CDK4HPRD;

interacts with

 CDK6HPRD;

interacts with

 CDKN1ABIOGRID;

interacts with

 CDKN1AHPRD;

interacts with

 CDKN1CBIOGRID;

interacts with

 CDKN1CHPRD;

interacts with

 CDT1BIOGRID;

interacts with

 CDT1HPRD;

interacts with

 CDT1MINT;

interacts with

 CHAF1ABIOGRID;

interacts with

 CHAF1AHPRD;

interacts with

 CHAF1AMINT;

interacts with

 CHEK1BIOGRID;

interacts with

 CHTF18BIOGRID;

interacts with

 CHTF18HPRD;

interacts with

 CHTF8HPRD;

interacts with

 CLSPNBIOGRID;

interacts with

 CLSPNHPRD;

interacts with

 CUL1MINT;

interacts with

 CUL2MINT;

interacts with

 CUL3MINT;

interacts with

 CUL4ABIOGRID;

interacts with

 CUL4AMINT;

interacts with

 CUL4BMINT;

interacts with

 CUL5MINT;

interacts with

 DDB1BIOGRID;

interacts with

 DDB1MINT;

interacts with

 DDX11BIOGRID;

interacts with

 DHX9HPRD;

interacts with

 DMAP1BIOGRID;

interacts with

 DNMT1BIOGRID;

interacts with

 DNMT1HPRD;

interacts with

 DNTTIP2HPRD;

interacts with

 DNTTBIOGRID;

interacts with

 DNTTHPRD;

interacts with

 DSCC1HPRD;

interacts with

 EEF1A1MINT;

interacts with

 EEF1A2MINT;

interacts with

 EEF2MINT;

interacts with

 EGFRBIOGRID;

interacts with

 EIF2AMINT;

interacts with

 ELP3BIOGRID;

interacts with

 EMG1MINT;

interacts with

 ENO1MINT;

interacts with

 EP300BIOGRID;

interacts with

 EP300HPRD;

interacts with

 ERCC4MINT;

interacts with

 ERCC5BIOGRID;

interacts with

 ERCC5HPRD;

interacts with

 ERCC6BIOGRID;

interacts with

 FAN1BIOGRID;

interacts with

 FANCABIOGRID;

interacts with

 FANCD2BIOGRID;

interacts with

 FANCEBIOGRID;

interacts with

 FANCLBIOGRID;

interacts with

 FEN1BIOGRID;

interacts with

 FEN1HPRD;

interacts with

 GADD45ABIOGRID;

interacts with

 Gadd45bBIOGRID;

interacts with

 GADD45BHPRD;

interacts with

 GADD45GBIOGRID;

interacts with

 GADD45GHPRD;

interacts with

 GAPDHMINT;

interacts with

 GCN1L1MINT;

interacts with

 H2AFXMINT;

interacts with

 HARSMINT;

interacts with

 HDAC1BIOGRID;

interacts with

 HIST2H2BEMINT;

interacts with

 HLTFBIOGRID;

interacts with

 HLTFHPRD;

interacts with

 HUS1BIOGRID;

interacts with

 HUS1HPRD;

interacts with

 IL17RBBIOGRID;

interacts with

 ING1BIOGRID;

interacts with

 ING1HPRD;

interacts with

 ING2BIOGRID;

interacts with

 ING2MINT;

interacts with

 KARSMINT;

interacts with

 KCTD13BIOGRID;

interacts with

 KCTD13HPRD;

interacts with

 KRT7MINT;

interacts with

 LIG1BIOGRID;

interacts with

 LIG1HPRD;

interacts with

 MAPK15BIOGRID;

interacts with

 MBD1BIOGRID;

interacts with

 MCL1BIOGRID;

interacts with

 MCL1HPRD;

interacts with

 MCM4MINT;

interacts with

 MCM5MINT;

interacts with

 MDH2MINT;

interacts with

 MDM2BIOGRID;

interacts with

 MSH2BIOGRID;

interacts with

 MSH2HPRD;

interacts with

 MSH3BIOGRID;

interacts with

 MSH3HPRD;

interacts with

 MSH6BIOGRID;

interacts with

 MSH6HPRD;

interacts with

 MUTYHBIOGRID;

interacts with

 MUTYHHPRD;

interacts with

 MYBBP1ABIOGRID;

interacts with

 MYBBP1AHPRD;

interacts with

 NAE1MINT;

interacts with

 NEDD8MINT;

interacts with

 OTUB1BIOGRID;

interacts with

 PAFBIOGRID;

interacts with

 PARP1BIOGRID;

interacts with

 PARP1HPRD;

interacts with

 PGAM1MINT;

interacts with

 PGK1MINT;

interacts with

 PIAS1MINT;

interacts with

 PIAS2MINT;

interacts with

 PMS2BIOGRID;

interacts with

 POLA1HPRD;

interacts with

 POLBBIOGRID;

interacts with

 POLBHPRD;

interacts with

 POLD1BIOGRID;

interacts with

 POLD1HPRD;

interacts with

 POLD2BIOGRID;

interacts with

 POLD3BIOGRID;

interacts with

 POLD3HPRD;

interacts with

 POLDIP2BIOGRID;

interacts with

 POLDIP2HPRD;

interacts with

 POLEBIOGRID;

interacts with

 POLEHPRD;

interacts with

 POLHBIOGRID;

interacts with

 POLHHPRD;

interacts with

 PoliBIOGRID;

interacts with

 POLIHPRD;

interacts with

 PolkBIOGRID;

interacts with

 POLKBIOGRID;

interacts with

 POLLBIOGRID;

interacts with

 POLLHPRD;

interacts with

 POLMHPRD;

interacts with

 POLNBIOGRID;

interacts with

 PPIAMINT;

interacts with

 PPP1CAHPRD;

interacts with

 PRDX6MINT;

interacts with

 PRIM2HPRD;

interacts with

 PRKDCBIOGRID;

interacts with

 PRKDCHPRD;

interacts with

 PRPF3MINT;

interacts with

 RAD18BIOGRID;

interacts with

 RAD18HPRD;

interacts with

 RAD9AHPRD;

interacts with

 RBBP8HPRD;

interacts with

 RFC1BIOGRID;

interacts with

 RFC1HPRD;

interacts with

 RFC2BIOGRID;

interacts with

 RFC2HPRD;

interacts with

 RFC3BIOGRID;

interacts with

 RFC3HPRD;

interacts with

 RFC4BIOGRID;

interacts with

 RFC4HPRD;

interacts with

 RFC5BIOGRID;

interacts with

 RFC5HPRD;

interacts with

 RPA1BIOGRID;

interacts with

 RPA1HPRD;

interacts with

 RPL12MINT;

interacts with

 RPL13MINT;

interacts with

 RPL18MINT;

interacts with

 RPL21MINT;

interacts with

 RPL29MINT;

interacts with

 RPL35AMINT;

interacts with

 RPL5MINT;

interacts with

 RPL6MINT;

interacts with

 RPL7MINT;

interacts with

 RPL9MINT;

interacts with

 RPS2MINT;

interacts with

 RPS3MINT;

interacts with

 RPSAMINT;

interacts with

 RUVBL2BIOGRID;

interacts with

 SEC23IPHPRD;

interacts with

 SETD8BIOGRID;

interacts with

 SETDB1BIOGRID;

interacts with

 SETMARBIOGRID;

interacts with

 SF3B3MINT;

interacts with

 SMARCA4BIOGRID;

interacts with

 SSRP1MINT;

interacts with

 SUB1HPRD;

interacts with

 SUMO3MINT;

interacts with

 TARSMINT;

interacts with

 TCOF1HPRD;

interacts with

 TIMELESSBIOGRID;

interacts with

 TIMELESSHPRD;

interacts with

 TOP1HPRD;

interacts with

 TPI1MINT;

interacts with

 UBE2BHPRD;

interacts with

 UBE2MMINT;

interacts with

 UBE2NHPRD;

interacts with

 UBE2V2HPRD;

interacts with

 UNGHPRD;

interacts with

 USP1BIOGRID;

interacts with

 WDR48BIOGRID;

interacts with

 WRNBIOGRID;

interacts with

 WRNHPRD;

interacts with

 WRNMINT;

interacts with

 XPCMINT;

interacts with

 XRCC1BIOGRID;

interacts with

 XRCC1HPRD;

interacts with

 XRCC5BIOGRID;

interacts with

 XRCC5HPRD;

interacts with

 XRCC6BIOGRID;

interacts with

 XRCC6HPRD;

interacts with

 YBX1BIOGRID;

interacts with

 YBX1HPRD;

interacts with

 YWHAGMINT;

interacts with

 YWHAHMINT;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

metabolic catalysis

 LIN37REACTOME;

metabolic catalysis

 LIN52REACTOME;

metabolic catalysis

 LIN54REACTOME;

metabolic catalysis

 LIN9REACTOME;

metabolic catalysis

 RBBP4REACTOME;

metabolic catalysis

 RBL2REACTOME;

metabolic catalysis

 TP53NCI_NATURE;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 BARD1NCI_NATURE;

reacts with

 BRCA1NCI_NATURE;

reacts with

 CDC25AREACTOME;

reacts with

 CDC6REACTOME;

reacts with

 DNA2REACTOME;

reacts with

 E2F1REACTOME;

reacts with

 ESR1NCI_NATURE;

reacts with

 FEN1REACTOME;

reacts with

 PCNANCI_NATURE;

reacts with

 PCNAREACTOME;

reacts with

 POLA1REACTOME;

reacts with

 POLA2REACTOME;

reacts with

 POLD1REACTOME;

reacts with

 POLD2REACTOME;

reacts with

 POLD3REACTOME;

reacts with

 POLD4REACTOME;

reacts with

 POLE2REACTOME;

reacts with

 POLEREACTOME;

reacts with

 PRIM1REACTOME;

reacts with

 PRIM2REACTOME;

reacts with

 RAD51NCI_NATURE;

reacts with

 RBL1REACTOME;

reacts with

 RFC1REACTOME;

reacts with

 RFC2REACTOME;

reacts with

 RFC3REACTOME;

reacts with

 RFC4REACTOME;

reacts with

 RFC5REACTOME;

reacts with

 RPA1REACTOME;

reacts with

 RPA2REACTOME;

reacts with

 RPA3REACTOME;

reacts with

 TOP2AREACTOME;

state change

 FEN1REACTOME;

state change

 LIG1REACTOME;

state change

 POLD1REACTOME;

state change

 POLD2REACTOME;

state change

 POLD3REACTOME;

state change

 POLD4REACTOME;

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