| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3815 |
Name | KIT |
Synonymous | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;KIT;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
Definition | mast/stem cell growth factor receptor Kit|p145 c-kit|piebald trait protein|proto-oncogene c-Kit|proto-oncogene tyrosine-protein kinase Kit|soluble KIT variant 1|tyrosine-protein kinase Kit|v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein |
Position | 4q12 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | c-Kit(h) + ATP --> c-Kit(h){pY} + ADP (phosphorylation; automodification) | c-Kit(h) + STAT1alpha(h) <==> c-Kit(h):STAT1alpha(h) (binding) | c-Kit(h) + STAT5A(h) <==> c-Kit(h):STAT5A(h) (binding) | c-Kit(h) + STAT5B(h) <==> c-Kit(h):STAT5B(h) (binding) | (SCF(h))2 + 2 c-Kit(h) <==> (c-Kit(h))2:(SCF(h))2 (binding) | c-Kit(h) + Jak2(h) <==> c-Kit(h):Jak2(h) (binding) | c-Kit(h) + ATP --> c-Kit(h){pY936} + ADP (phosphorylation; automodification) | c-Kit(h) + ATP --> c-Kit(h){pY703} + ADP (phosphorylation; automodification) | c-Kit(h) + MUPP-1(m) <==> c-Kit(h):MUPP-1(m) (binding) | c-Kit(h) + ATP --> c-Kit(h){p} + ADP (phosphorylation) | c-Kit(h) + ATP --> c-Kit(h){pY936} + ADP (phosphorylation) | c-Kit(h) + ATP --> c-Kit(h){pY} + ADP (phosphorylation) | KIT(h) --> c-Kit(h) (expression). | p53(h) --> c-Kit(h) (increase of abundance) | UV-B --> c-Kit(h) (increase of abundance) | STAT1alpha(h) + ATP --c-Kit(h)--> STAT1alpha(h){pY} + ADP (phosphorylation) | STAT5A(h) + ATP --c-Kit(h)--> STAT5A(h){pY} + ADP (phosphorylation) | STAT5B(h) + ATP --c-Kit(h)--> STAT5B(h){pY} + ADP (phosphorylation) | c-Kit(h) + ubiquitin(pg) --> c-Kit(h){ub} (ubiquitination) | c-Kit(h) + 2 ATP --> c-Kit(h){pY568}{pY936} + 2 ADP (phosphorylation) | c-Cbl(h) + c-Kit(h) <==> c-Cbl(h):c-Kit(h) (binding) | c-Kit(h) + c-Cbl(mo) <==> c-Kit(h):c-Cbl(mo) (binding) | c-Kit(h) + 2 ATP --> c-Kit(h){pY703}{pY936} + 2 ADP (phosphorylation) | ubiquitin(h) + c-Kit(h) --> c-Kit(h){ub} (ubiquitination) | SCF(h) + c-Kit(h) <==> SCF(h):c-Kit(h) (binding) | KIT(h) --> c-Kit(h) (expression). | KIT(h) --> kit(h) (expression). | hsa-miR-146a --/ kit(h) (predicted) | hsa-miR-221 --/ kit(h) (predicted) | hsa-miR-221 --/ kit(h) (translational repression) | hsa-miR-222 --/ kit(h) (predicted) | hsa-miR-222 --/ kit(h) (translational repression) |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 130 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 145 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 283 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 293 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 300 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 320 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 352 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 367 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 463 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 486 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 823 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 568 | Phosphotyrosine (Kit) | 9799234 | Phospho.ELM 6.0 | 570 | Phosphotyrosine (Kit) | 9799234 | Phospho.ELM 6.0 | 936 | Phosphotyrosine (Kit) | 10377264 | Phospho.ELM 6.0 | 959 | Phosphoserine (Kit;PKC alph) | 7539802 | Phospho.ELM 6.0 | 703 | Phosphotyrosine (Kit) | 10377264 | Phospho.ELM 6.0 | 721 | Phosphotyrosine | N.N.;9038210 | Phospho.ELM 6.0 | 823 | Phosphotyrosine | N.N. | Phospho.ELM 6.0 | 741 | Phosphoserine (PKC alpha) | 7539802 | Phospho.ELM 6.0 | 746 | Phosphoserine (PKC alpha) | 7539802 | Phospho.ELM 6.0 | 821 | Phosphoserine (Kit;PKC alph) | 7539802 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr4 |
Promoter: 55217418 - 55219418 | Agilent_014791 |
chr4 |
Promoter: 55217418 - 55219418 | GoldenGate_Methylation_Cancer_Panel_I |
chr4 |
Promoter: 55217418 - 55219418 | GSE27584 |
chr4 |
Promoter: 55217418 - 55219418 | Agilent_014791_44K |