| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3725 |
Name | JUN |
Synonymous | jun proto-oncogene;JUN;jun proto-oncogene |
Definition | Jun activation domain binding protein|activator protein 1|enhancer-binding protein AP1|jun oncogene|p39|proto-oncogene c-Jun|transcription factor AP-1|v-jun avian sarcoma virus 17 oncogene homolog|v-jun sarcoma virus 17 oncogene homolog |
Position | 1p32-p31 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | c-Jun(h) + ATP --JNK1(h)--> c-Jun(h){p} + ADP (phosphorylation) | c-Jun(h) --> SLC3A2(h) (DNA binding). | c-Jun(h) --> BZLF1(EBV) (DNA binding). | c-Jun(h) --> MMP1(h) (DNA binding). | c-Jun(h) --> MT2A(h) (DNA binding). | c-Jun(h) --> ENK(h) (DNA binding). | c-Jun(h) --> PLF(m) (DNA binding). | c-Jun(h) --> Sst(r) (DNA binding). | c-Jun(h) --> SV40(sv) (DNA binding). | c-Jun(h) --> VIP(h) (DNA binding). | c-Jun(h) --> HBB(h) (DNA binding). | c-Jun(h) --> MMTV(MMTV) (DNA binding). | c-Jun(h) --> junD(m) (DNA binding). | c-Jun(h) --> IL2(h) (DNA binding). | c-Jun(h) --> AFP(r) (DNA binding). | c-Jun(h) --> EDN1(h) (DNA binding). | c-Jun(h) --> JUN(h) (DNA binding). | c-Jun(h) --> uPA(h) (DNA binding). | c-Jun(h) --> TP53(h) (DNA binding). | c-Jun(h) --> SELE(h) (DNA binding). | c-Jun(h) --> ATF3(h) (DNA binding). | ATF(h) + c-Jun(h) <==> ATF(h):c-Jun(h) (binding). | c-Fos(m) + c-Jun(h) <==> c-Fos(m):c-Jun(h) (binding). | c-Fos(h) + c-Jun(h) <==> c-Fos(h):c-Jun(h) (binding). | c-Fos(r) + c-Jun(h) <==> c-Fos(r):c-Jun(h) (binding). | c-Fos(c) + c-Jun(h) <==> c-Fos(c):c-Jun(h) (binding). | ATF-2-isoform2(m) + c-Jun(h) <==> ATF-2-isoform2(m):c-Jun(h) (binding). | ATF-2(r) + c-Jun(h) <==> ATF-2(r):c-Jun(h) (binding). | RelA-p65(h) + c-Jun(h) <==> RelA-p65(h):c-Jun(h) (binding). | C/EBPbeta(h) + c-Jun(h) <==> C/EBPbeta(h):c-Jun(h) (binding). | c-Jun(h) + ATF-2-xbb4(h) <==> c-Jun(h):ATF-2-xbb4(h) (binding). | GR-alpha(h) + c-Jun(h) <==> GR-alpha(h):c-Jun(h) (binding). | GR(m) + c-Jun(h) <==> GR(m):c-Jun(h) (binding). | GR(r) + c-Jun(h) <==> GR(r):c-Jun(h) (binding). | FosB(m) + c-Jun(h) <==> FosB(m):c-Jun(h) (binding). | Fra-1(m) + c-Jun(h) <==> Fra-1(m):c-Jun(h) (binding). | GR(c) + c-Jun(h) <==> GR(c):c-Jun(h) (binding). | GR(fc) + c-Jun(h) <==> GR(fc):c-Jun(h) (binding). | v-Fos(FBRMULV) + c-Jun(h) <==> v-Fos(FBRMULV):c-Jun(h) (binding). | E1A 12S protein(AD) + c-Jun(h) <==> E1A 12S protein(AD):c-Jun(h) (binding). | ATF-3(r) + c-Jun(h) <==> ATF-3(r):c-Jun(h) (binding). | Fra-1(r) + c-Jun(h) <==> Fra-1(r):c-Jun(h) (binding). | c-Jun(h) + CREBPA(h) <==> CREBPA(h):c-Jun(h) (binding). | ATF-3(h) + c-Jun(h) <==> ATF-3(h):c-Jun(h) (binding). | E7(HPV16) + c-Jun(h) <==> E7(HPV16):c-Jun(h) (binding). | ATF-2(h) + c-Jun(h) <==> ATF-2(h):c-Jun(h) (binding). | GR-beta(h) + c-Jun(h) <==> GR-beta(h):c-Jun(h) (binding). | Fra-2(c) + c-Jun(h) <==> Fra-2(c):c-Jun(h) (binding). | deltaFosB(m) + c-Jun(h) <==> deltaFosB(m):c-Jun(h) (binding). | CBP(h) + c-Jun(h) <==> CBP(h):c-Jun(h) (binding). | p300(h) + c-Jun(h) <==> p300(h):c-Jun(h) (binding) | c-Jun(h) + ATP --CSN(h)--> c-Jun(h){pT}{pS} + ADP (phosphorylation) | c-Jun(h) + c-Jun(h) <==> c-Jun(h):c-Jun(h) (binding). | ATF-4(h) + c-Jun(h) <==> ATF-4(h):c-Jun(h) (binding). | NRL(h) + c-Jun(h) <==> NRL(h):c-Jun(h) (binding). | E1A 13S protein(AD2) + c-Jun(h) <==> E1A 13S protein(AD2):c-Jun(h) (binding). | c-Jun(h) + NTP --JNK2(r){p}--> c-Jun(h){p} + NDP (phosphorylation) | c-Jun(h) --> IL-5(h) (DNA binding; transactivation). | c-Jun(h) --> CCL5(h) (DNA binding). | Sp1(h) + c-Jun(h) <==> c-Jun(h):Sp1(h) (assembly; binding; interaction) | c-Jun(h) + COP1(h) <==> c-Jun(h):COP1(h) (binding) | c-Jun(h) + n ubiquitin(h) --COP1(h),DET1(h)--> c-Jun(h){ub(n)} (ubiquitination) | c-Jun(h) + n ubiquitin(v.s.) --E1(rb),Ubc5C(h),DET1(h),DDB1(h),CUL4A(m),Roc1(h),COP1(h),ATP--> c-Jun(h){ub(n)} (ubiquitination) | c-Jun(h) --> GJA1(h) (DNA binding; transactivation). | c-Jun(h) --> KRT16(h) (DNA binding; transactivation). | c-Jun(h) --> BCL2A1(h) (DNA binding; transactivation). | c-Jun(h) + 2 ATP --JNK1(h)--> c-Jun(h){pS63}{pS73} + 2 ADP (phosphorylation) | c-Jun(h) --> MSH2(h) (DNA binding; transactivation). | c-Jun(h) + jdp2(r) <==> c-Jun(h):jdp2(r) (binding) | batf3(r) + c-Jun(h) <==> c-Jun(h):batf3(r) (binding) | c-Jun(h) --> SPP1(r) (DNA binding; transactivation). | c-Jun(h) --> NAT1(h) (DNA binding). | AML3(m) + c-Jun(h) <==> AML3(m):c-Jun(h) (binding) | AML1(m) + c-Jun(h) <==> AML1(m):c-Jun(h) (binding) | c-Jun(h) + 3 ubiquitin(m.s.) --E2-20K(rb)--> c-Jun(h){ub(3)} (ubiquitination) | ubiquitin(m.s.) + c-Jun(h) --HR6B(rb)--> c-Jun(h){ub(1)} (ubiquitination) | c-Jun(h) + 2 ubiquitin(m.s.) --E2-32K(rb)--> c-Jun(h){ub(2)} (ubiquitination) | n ubiquitin(m.s.) + c-Jun(h) --HR6B(rb)--> c-Jun(h){ub(n)} (ubiquitination) | c-Jun(h) + 4 ubiquitin(m.s.) --HR6B(rb)--> c-Jun(h){ub(4)} (ubiquitination) | c-Jun(h) + 2 ubiquitin(m.s.) --HR6B(rb)--> c-Jun(h){ub(2)} (ubiquitination) | c-Jun(h) + 3 ubiquitin(m.s.) --HR6B(rb)--> c-Jun(h){ub(3)} (ubiquitination) | c-Jun(h) + 5 ubiquitin(m.s.) --HR6B(rb)--> c-Jun(h){ub(5)} (ubiquitination) | c-Jun(h) + TFIIB(m.s.) <==> c-Jun(h):TFIIB(m.s.) (binding) | STAT1(h) + c-Jun(h) <==> STAT1(h):c-Jun(h) (binding) [re. | STAT3(h) + c-Jun(h) <==> STAT3(h):c-Jun(h) (binding) [re. | c-Jun(h) + STAT3(m.s.) <==> c-Jun(h):STAT3(m.s.) (binding) [re. | c-Jun(h) --> TNF(h) (DNA binding; transactivation). | c-Jun(h) + KRC(h) <==> c-Jun(h):KRC(h) (binding) | c-Jun(h) + ATP --> c-Jun(h){pS63} + ADP (phosphorylation) | c-Jun(h) + PML(h) <==> c-Jun(h):PML(h) (binding) | c-Jun(h) + TopoI(h) <==> c-Jun(h):TopoI(h) (binding) | TopoI(h) + c-Jun(h) + TBP(h) <==> TopoI(h):c-Jun(h):TBP(h) (binding) | c-Jun(h) + TopoI(h) <==> c-Jun(h):TopoI(h) (binding) | c-Jun(h) --> ErbB1(h) (increase of abundance) | c-Jun(h) + ATP --> c-Jun(h){p} + ADP (phosphorylation) | c-Jun(h) --> PCNA(h) (increase of abundance) | c-Jun(h) + Elf-1(h) <==> c-Jun(h):Elf-1(h) (binding) [re. | c-Jun(h) + Gu-alpha(h) <==> c-Jun(h):Gu-alpha(h) (binding) | c-Jun(h) + Gu-alpha(h) <==> c-Jun(h):Gu-alpha(h) (binding) | c-Jun(h) + brca1(h) <==> c-Jun(h):brca1(h) (binding) | c-Jun(h) --> TERT(h) (DNA binding). | c-Jun(h) --> GSS(h) (DNA binding). | YY1(h) + c-Jun(h) <==> YY1(h):c-Jun(h) (binding) | c-Jun(h) --> PTGS2(h) (transactivation) | c-Jun(h) --> GNRHR(h) (DNA binding; transactivation). | c-Jun(h) + acetyl-CoA --> c-Jun(h){ace} + CoA (acetylation) | c-Jun(h) --> APP(h) (DNA binding; transactivation). | c-Jun(h) + ATP --> c-Jun(h){pS73} + ADP (phosphorylation) [re | c-Jun(h) --/ BRCA1(h) (DNA binding; transrepression). | c-Jun(h) --> CD82(h) (DNA binding). | c-Jun(h) --> TNFRSF10A(h) (DNA binding). | c-Jun(h) --> TGM1(h) (DNA binding). | C/EBPalpha(r) + c-Jun(h) <==> C/EBPalpha(r):c-Jun(h) (binding) | c-Jun(h) --> GSTP1(h) (DNA binding). | c-Jun(h) --> STAT4(h) (DNA binding). | c-Jun(h) + CBP(h) <==> CBP(h):c-Jun(h) (binding) | Fra-1(m.s.) + c-Jun(h) <==> Fra-1(m.s.):c-Jun(h) (binding) | c-Jun(h) + ER-alpha(h) <==> c-Jun(h):ER-alpha(h) (binding) | c-Jun(h) --> CYP19A1(h) (DNA binding). | c-Jun(h) --> CCND1(h) (DNA binding). | c-Jun(h) + CREB1(h) <==> c-Jun(h):CREB1(h) (binding) | c-Jun(h) + bad(h) <==> c-Jun(h):bad(h) (binding) | c-Jun(h) --> IFNG(h) (DNA binding). | c-Jun(h) --> MMP2(h) (DNA binding). | c-Jun(h) --> FGF2(h) (DNA binding). | c-Jun(h) + 2 ATP --> c-Jun(h){pS63}{pS73} + 2 ADP (phosphorylation) | c-Jun(h) --> VIM(h) (DNA binding). | c-Jun(h) --> C3AR1(h) (DNA binding; transactivation). | c-Jun(h) --> SCNN1B(r) (DNA binding). | c-Jun(h) --> IL8(h) (DNA binding). | c-Jun(h) --> MUC2(h) (DNA binding). | c-Jun(h) --> IVL(h) (DNA binding). | c-Jun(h) --> CYP2J2(h) (DNA binding). | c-Jun(h) --> MMP13(h) (DNA binding). | c-Jun(h) --> Cyp4a11(r) (DNA binding). | c-Jun(h) + ATP --JNK(m.s.)--> c-Jun(h){pS63} + ADP (phosphorylation) | c-Jun(h) --> CD44(h) (DNA binding). | c-Jun(h) --> CSPG2(h) (DNA binding; transactivation). | c-Jun(h) --> SERPINB9(h) (DNA binding). | c-Jun(h) --> ICAM1(h) (DNA binding). | c-Jun(h) --> IL11(h) (DNA binding). | c-Jun(h) --> HK1(h) (DNA binding). | c-Jun(h) --/ FOXN1(h) (transrepression) | c-Jun(h) --> NPY(h) (DNA binding). | c-Jun(h) --> FASLG(h) (DNA binding). | c-Jun(h) --> FAS(h) (DNA binding). | c-Jun(h) --/ NOTCH1(h) (transrepression) | c-Jun(h) --/ Notch1(h) (decrease of abundance) | c-Jun(h) --/ TP53(h) (transrepression) | c-Jun(h) --> TBXA2R(h) (DNA binding). | c-Jun(h) --> CSF1(h) (DNA binding). | c-Jun(h) --> CP(h) (DNA binding). | c-Jun(h) --> Agtr1b(r) (DNA binding). | c-Jun(h) --> Jun(m) (DNA binding). | c-Jun(h) --> ITGB8(h) (DNA binding). | c-Jun(h) --> IBSP(h) (DNA binding). | c-Jun(h) --> XYLT1(h) (DNA binding). | IKK-gamma(h) --> c-Jun(h) (activation; phosphorylation) | JUN(h) --> c-Jun(h) (expression). | P2RX7(h) --> c-Jun(h) (increase of abundance) | Cnk1(h) --> c-Jun(h) (increase of abundance) | ARHGEF1(m.s.) --> c-Jun(h) (increase of abundance) | NET1(m.s.) --> c-Jun(h) (increase of abundance) | TGFbeta1(h) --> c-Jun(h) (increase of abundance) | senp1(h) --> c-Jun(h) (increase of abundance) | EGF(h) --> c-Jun(h) (increase of abundance) | IL-17A(h) --> c-Jun(h) (increase of abundance) | c-Jun(h) --> E4(AD) (DNA binding). | c-Jun(h) --> FN1(h) (DNA binding). | c-Jun(h) --> Il2(m) (DNA binding). | c-Jun(h) --> TSHB(h) (DNA binding). | c-Jun(h) --> TNF(h) (transactivation) [re. | c-Jun(h) --> NPPA(h) (DNA binding). | c-Jun(h) --> CCND1(h) (DNA binding). | c-Jun(h) --> Il4(m) (DNA binding). | c-Jun(h) --> ITGAX(h) (DNA binding; transactivation). | c-Jun(h) --> SP-B(rb) (DNA binding). | c-Jun(h) --> IFNB1(h) (DNA binding; transactivation). | c-Jun(h) --/ Slc2a2(r) (DNA binding; transrepression). | c-Jun(h) --/ Trp53(m) (DNA binding; transrepression). | c-Jun(h) + Pit-1(m.s.) <==> c-Jun(h):Pit-1(m.s.) (binding) | CKII-alpha(h) + c-Jun(h) <==> CKII-alpha(h):c-Jun(h) (binding) | MBF-1alpha(h) + c-Jun(h) <==> MBF-1alpha(h):c-Jun(h) (binding) | c-Jun(h) + HOXD12(c) <==> c-Jun(h):HOXD12(c) (binding) | c-Jun(h) + SPI1(m) <==> c-Jun(h):SPI1(m) (binding) | ATF-2-xbb4(h) + c-Jun(h) <==> ATF-2-xbb4(h):c-Jun(h) (binding) | ATFa-isoform3(h) + c-Jun(h) <==> ATFa-isoform3(h):c-Jun(h) (binding) | CREBPA-Alpha(h) + c-Jun(h) <==> CREBPA-Alpha(h):c-Jun(h) (binding) | 2 c-Jun(h) <==> (c-Jun(h))2 (oligomerization) | c-Jun(h) + JunD(h) <==> c-Jun(h):JunD(h) (binding) | c-Jun(h) + FosB(h) <==> c-Jun(h):FosB(h) (binding) | c-Jun(h) + c-Fos(h) <==> c-Jun(h):c-Fos(h) (binding) | c-Jun(h) + Fra-1(h) <==> c-Jun(h):Fra-1(h) (binding) | c-Jun(h) + Fra-2(h) <==> c-Jun(h):Fra-2(h) (binding) | c-Jun(h) + ATF-3(h) <==> c-Jun(h):ATF-3(h) (binding) | c-Jun(h) + B-ATF(h) <==> c-Jun(h):B-ATF(h) (binding) | c-Jun(h) + batf3(h) <==> c-Jun(h):batf3(h) (binding) | c-Jun(h) + Hlf(h) <==> c-Jun(h):Hlf(h) (binding) | c-Jun(h) + MafK(h) <==> c-Jun(h):MafK(h) (binding) | c-Jun(h) + Nrf2(h) <==> c-Jun(h):Nrf2(h) (binding) | c-Jun(h) + MafG(h) <==> c-Jun(h):MafG(h) (binding) | c-Jun(h) --> PTGS2(h) (transactivation) | c-Jun(h) + ATP --JNK1alpha1(h)--> c-Jun(h){p} + ADP (phosphorylation) | c-Jun(h) + ATP --JNK2alpha-2(h)--> c-Jun(h){p} + ADP (phosphorylation) | c-Jun(h) + acetyl-CoA --p300(m.s.)--> c-Jun(h){aceK271} + CoA (acetylation) | c-Jun(h) + acetyl-CoA --> c-Jun(h){aceK271} + CoA (acetylation) | 15d-PGJ2 + c-Jun(h) <==> 15d-PGJ2:c-Jun(h) (binding) | COUP-TF2(m.s.) + c-Jun(h) <==> COUP-TF2(m.s.):c-Jun(h) (binding) | C/EBPalpha(h) + c-Jun(h) <==> C/EBPalpha(h):c-Jun(h) (binding) | c-Jun(h) + C/EBPalpha(r) <==> c-Jun(h):C/EBPalpha(r) (binding) | c-Jun(h) --> JUN(h) (DNA binding). | c-Jun(h) --> MAT2A(h) (DNA binding; transactivation). | c-Jun(h) + ATP --JNK1(h)--> c-Jun(h){p} + ADP (phosphorylation) | c-Jun(h) + ATP --> c-Jun(h){p} + ADP (phosphorylation) | c-Jun(h) + ATP --inositol-tetrakisphosphate 1-kinase(b)--> c-Jun(h){pS} + ADP (phosphorylation) | c-Jun(h) + 2 ATP --> c-Jun(h){pS63}{pS73} + 2 ADP (phosphorylation) | c-Jun(h) --> EZR(h) (DNA binding). | c-Jun(h) --> CYP2J2(h) (DNA binding). | c-Jun(h) + SIRT1(h) <==> c-Jun(h):SIRT1(h) (binding) | c-Jun(h) + acetyl-CoA --p300(m.s.)--> c-Jun(h){aceK} + CoA (acetylation) | JUN(h) --> c-Jun(h) (expression). | c-Jun(h){aceK} --SIRT1(m.s.)--> c-Jun(h) + acetyl (deacetylation) |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 63 | Phosphoserine (by MAPK8). | Swiss-Prot 53.0 | 73 | Phosphoserine (by MAPK8). | Swiss-Prot 53.0 | 243 | Phosphoserine (ERT PK;CK2 a) | 91332050;1516134;1846781 | Phospho.ELM 6.0 | 170 | Phosphotyrosine (Abl) | 15302935;14757045 | Phospho.ELM 6.0 | 91 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 | 93 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 59021873 - 59023873 | Agilent_014791 |
chr1 |
Promoter: 59021873 - 59023873 | GSE27584 |
chr1 |
Promoter: 59021873 - 59023873 | Agilent_014791_44K |
chr1 |
Promoter: 59021873 - 59023873 | Agilent_014791 |