| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3725 |
Name | JUN |
Synonym | AP-1|AP1|c-Jun;jun proto-oncogene;JUN;jun proto-oncogene |
Definition | Jun activation domain binding protein|activator protein 1|enhancer-binding protein AP1|jun oncogene|p39|proto-oncogene c-Jun|transcription factor AP-1|v-jun avian sarcoma virus 17 oncogene homolog|v-jun sarcoma virus 17 oncogene homolog |
Position | 1p32-p31 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | pertussis toxin-insensitive ccr5 signaling in macrophage;PID BioCarta;100214 |
Pathway | mechanism of gene regulation by peroxisome proliferators via ppara;PID BioCarta;100066 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | pdgf signaling pathway;PID BioCarta;100077 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | atm signaling pathway;PID BioCarta;100235 |
Pathway | inhibition of cellular proliferation by gleevec;PID BioCarta;100154 |
Pathway | Regulation of retinoblastoma protein;PID Curated;200191 |
Pathway | Endothelins;PID Curated;200004 |
Pathway | Presenilin action in Notch and Wnt signaling;PID Curated;200052 |
Pathway | toll-like receptor pathway;PID BioCarta;100013 |
Pathway | bcr signaling pathway;PID BioCarta;100227 |
Pathway | Huntington disease;PANTHER;P00029 |
Pathway | IL1-mediated signaling events;PID Curated;200075 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | tpo signaling pathway;PID BioCarta;100012 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221 |
Pathway | Nephrin/Neph1 signaling in the kidney podocyte;PID Curated;200132 |
Pathway | FOXA1 transcription factor network;PID Curated;200194 |
Pathway | IL12 signaling mediated by STAT4;PID Curated;200197 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | signal transduction through il1r;PID BioCarta;100132 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | Oxidative stress response;PANTHER;P00046 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | CD40/CD40L signaling;PID Curated;200031 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | mets affect on macrophage differentiation;PID BioCarta;100169 |
Pathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes;PID Curated;200039 |
Pathway | Downstream signaling in naive CD8+ T cells;PID Curated;200184 |
Pathway | Epithelial cell signaling in Helicobacter pylori infection;KEGG PATHWAY;hsa05120 |
Pathway | hypoxia-inducible factor in the cardivascular system;PID BioCarta;100145 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | the 41bb-dependent immune response;PID BioCarta;100257 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | agrin in postsynaptic differentiation;PID BioCarta;100252 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | d4gdi signaling pathway;PID BioCarta;100191 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Pathway | RhoA signaling pathway;PID Curated;200007 |
Pathway | ATF-2 transcription factor network;PID Curated;200116 |
Pathway | Signaling events regulated by Ret tyrosine kinase;PID Curated;200058 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Signaling mediated by p38-alpha and p38-beta;PID Curated;200154 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | FAS signaling pathway;PANTHER;P00020 |
Pathway | the information processing pathway at the ifn beta enhancer;PID BioCarta;100079 |
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106 |
Pathway | Regulation of Androgen receptor activity;PID Curated;200102 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | S1P2 pathway;PID Curated;200181 |
Pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2;PID Curated;200044 |
Pathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Pathway | nerve growth factor pathway (ngf);PID BioCarta;100096 |
Pathway | repression of pain sensation by the transcriptional regulator dream;PID BioCarta;100186 |
Pathway | tnf/stress related signaling;PID BioCarta;100026 |
Pathway | RAC1 signaling pathway;PID Curated;200190 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Glucocorticoid receptor regulatory network;PID Curated;200077 |
Pathway | igf-1 signaling pathway;PID BioCarta;100136 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | oxidative stress induced gene expression via nrf2;PID BioCarta;100238 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | calcium signaling by hbx of hepatitis b virus;PID BioCarta;100150 |
Pathway | PDGFR-alpha signaling pathway;PID Curated;200140 |
Pathway | Calcium signaling in the CD4+ TCR pathway;PID Curated;200159 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | ErbB2/ErbB3 signaling events;PID Curated;200119 |
Pathway | tsp-1 induced apoptosis in microvascular endothelial cell;PID BioCarta;100010 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Activation of the AP-1 family of transcription factors;PID Reactome;500458 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | JNK signaling in the CD4+ TCR pathway;PID Curated;200129 |
Pathway | links between pyk2 and map kinases;PID BioCarta;100057 |
Pathway | AP-1 transcription factor network;PID Curated;200118 |
Pathway | il12 and stat4 dependent signaling pathway in th1 development;PID BioCarta;100133 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | cadmium induces dna synthesis and proliferation in macrophages;PID BioCarta;100209 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | FGF signaling pathway;PID Curated;200189 |
Disease | Lupus erythematosus;FunDO |
Disease | Vaccinia;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Sicca syndrome;FunDO |
Disease | Cognitive performance;GAD |
Disease | Hepatitis;FunDO |
Disease | Rheumatoid arthritis;FunDO |
Disease | Craniosynostosis;FunDO |
Disease | Cancer;FunDO |
Disease | NEUROLOGICAL;GAD |
Disease | Schizophrenia;FunDO |
Disease | Hypertension, Pulmonary;FunDO |
Disease | Cognitive performance;NHGRI |
External Links | |
Links to Entrez Gene | 3725 |
Links to all GeneRIF Items | 3725 |
Links to iHOP | 3725 |
Sequence Information | |
Nucleotide Sequence | >3725 : length: 3338 GACATCATGGGCTATTTTTAGGGGTTGACTGGTAGCAGATAAGTGTTGAGCTCGGGCTGG ATAAGGGCTCAGAGTTGCACTGAGTGTGGCTGAAGCAGCGAGGCGGGAGTGGAGGTGCGC GGAGTCAGGCAGACAGACAGACACAGCCAGCCAGCCAGGTCGGCAGTATAGTCCGAACTG CAAATCTTATTTTCTTTTCACCTTCTCTCTAACTGCCCAGAGCTAGCGCCTGTGGCTCCC GGGCTGGTGTTTCGGGAGTGTCCAGAGAGCCTGGTCTCCAGCCGCCCCCGGGAGGAGAGC CCTGCTGCCCAGGCGCTGTTGACAGCGGCGGAAAGCAGCGGTACCCACGCGCCCGCCGGG GGAAGTCGGCGAGCGGCTGCAGCAGCAAAGAACTTTCCCGGCTGGGAGGACCGGAGACAA GTGGCAGAGTCCCGGAGCGAACTTTTGCAAGCCTTTCCTGCGTCTTAGGCTTCTCCACGG CGGTAAAGACCAGAAGGCGGCGGAGAGCCACGCAAGAGAAGAAGGACGTGCGCTCAGCTT CGCTCGCACCGGTTGTTGAACTTGGGCGAGCGCGAGCCGCGGCTGCCGGGCGCCCCCTCC CCCTAGCAGCGGAGGAGGGGACAAGTCGTCGGAGTCCGGGCGGCCAAGACCCGCCGCCGG CCGGCCACTGCAGGGTCCGCACTGATCCGCTCCGCGGGGAGAGCCGCTGCTCTGGGAAGT GAGTTCGCCTGCGGACTCCGAGGAACCGCTGCGCCCGAAGAGCGCTCAGTGAGTGACCGC GACTTTTCAAAGCCGGGTAGCGCGCGCGAGTCGACAAGTAAGAGTGCGGGAGGCATCTTA ATTAACCCTGCGCTCCCTGGAGCGAGCTGGTGAGGAGGGCGCAGCGGGGACGACAGCCAG CGGGTGCGTGCGCTCTTAGAGAAACTTTCCCTGTCAAAGGCTCCGGGGGGCGCGGGTGTC CCCCGCTTGCCAGAGCCCTGTTGCGGCCCCGAAACTTGTGCGCGCAGCCCAAACTAACCT CACGTGAAGTGACGGACTGTTCTATGACTGCAAAGATGGAAACGACCTTCTATGACGATG CCCTCAACGCCTCGTTCCTCCCGTCCGAGAGCGGACCTTATGGCTACAGTAACCCCAAGA TCCTGAAACAGAGCATGACCCTGAACCTGGCCGACCCAGTGGGGAGCCTGAAGCCGCACC TCCGCGCCAAGAACTCGGACCTCCTCACCTCGCCCGACGTGGGGCTGCTCAAGCTGGCGT CGCCCGAGCTGGAGCGCCTGATAATCCAGTCCAGCAACGGGCACATCACCACCACGCCGA CCCCCACCCAGTTCCTGTGCCCCAAGAACGTGACAGATGAGCAGGAGGGCTTCGCCGAGG GCTTCGTGCGCGCCCTGGCCGAACTGCACAGCCAGAACACGCTGCCCAGCGTCACGTCGG CGGCGCAGCCGGTCAACGGGGCAGGCATGGTGGCTCCCGCGGTAGCCTCGGTGGCAGGGG GCAGCGGCAGCGGCGGCTTCAGCGCCAGCCTGCACAGCGAGCCGCCGGTCTACGCAAACC TCAGCAACTTCAACCCAGGCGCGCTGAGCAGCGGCGGCGGGGCGCCCTCCTACGGCGCGG CCGGCCTGGCCTTTCCCGCGCAACCCCAGCAGCAGCAGCAGCCGCCGCACCACCTGCCCC AGCAGATGCCCGTGCAGCACCCGCGGCTGCAGGCCCTGAAGGAGGAGCCTCAGACAGTGC CCGAGATGCCCGGCGAGACACCGCCCCTGTCCCCCATCGACATGGAGTCCCAGGAGCGGA TCAAGGCGGAGAGGAAGCGCATGAGGAACCGCATCGCTGCCTCCAAGTGCCGAAAAAGGA AGCTGGAGAGAATCGCCCGGCTGGAGGAAAAAGTGAAAACCTTGAAAGCTCAGAACTCGG AGCTGGCGTCCACGGCCAACATGCTCAGGGAACAGGTGGCACAGCTTAAACAGAAAGTCA TGAACCACGTTAACAGTGGGTGCCAACTCATGCTAACGCAGCAGTTGCAAACATTTTGAA GAGAGACCGTCGGGGGCTGAGGGGCAACGAAGAAAAAAAATAACACAGAGAGACAGACTT GAGAACTTGACAAGTTGCGACGGAGAGAAAAAAGAAGTGTCCGAGAACTAAAGCCAAGGG TATCCAAGTTGGACTGGGTTGCGTCCTGACGGCGCCCCCAGTGTGCACGAGTGGGAAGGA CTTGGCGCGCCCTCCCTTGGCGTGGAGCCAGGGAGCGGCCGCCTGCGGGCTGCCCCGCTT TGCGGACGGGCTGTCCCCGCGCGAACGGAACGTTGGACTTTTCGTTAACATTGACCAAGA ACTGCATGGACCTAACATTCGATCTCATTCAGTATTAAAGGGGGGAGGGGGAGGGGGTTA CAAACTGCAATAGAGACTGTAGATTGCTTCTGTAGTACTCCTTAAGAACACAAAGCGGGG GGAGGGTTGGGGAGGGGCGGCAGGAGGGAGGTTTGTGAGAGCGAGGCTGAGCCTACAGAT GAACTCTTTCTGGCCTGCCTTCGTTAACTGTGTATGTACATATATATATTTTTTAATTTG ATGAAAGCTGATTACTGTCAATAAACAGCTTCATGCCTTTGTAAGTTATTTCTTGTTTGT TTGTTTGGGTATCCTGCCCAGTGTTGTTTGTAAATAAGAGATTTGGAGCACTCTGAGTTT ACCATTTGTAATAAAGTATATAATTTTTTTATGTTTTGTTTCTGAAAATTCCAGAAAGGA TATTTAAGAAAATACAATAAACTATTGGAAAGTACTCCCCTAACCTCTTTTCTGCATCAT CTGTAGATACTAGCTATCTAGGTGGAGTTGAAAGAGTTAAGAATGTCGATTAAAATCACT CTCAGTGCTTCTTACTATTAAGCAGTAAAAACTGTTCTCTATTAGACTTTAGAAATAAAT GTACCTGATGTACCTGATGCTATGGTCAGGTTATACTCCTCCTCCCCCAGCTATCTATAT GGAATTGCTTACCAAAGGATAGTGCGATGTTTCAGGAGGCTGGAGGAAGGGGGGTTGCAG TGGAGAGGGACAGCCCACTGAGAAGTCAAACATTTCAAAGTTTGGATTGTATCAAGTGGC ATGTGCTGTGACCATTTATAATGTTAGTAGAAATTTTACAATAGGTGCTTATTCTCAAAG CAGGAATTGGTGGCAGATTTTACAAAAGATGTATCCTTCCAATTTGGAATCTTCTCTTTG ACAATTCCTAGATAAAAAGATGGCCTTTGCTTATGAATATTTATAACAGCATTCTTGTCA CAATAAATGTATTCAAATACCAAAAAAAAAAAAAAAAA |
Protein Sequence | >3725 : length: 331 MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF |