| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3667 |
Name | IRS1 |
Synonymous | insulin receptor substrate 1;IRS1;insulin receptor substrate 1 |
Definition | IRS-1 |
Position | 2q36 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IRS-1(h) + Grb-2(h) <==> IRS-1(h):Grb-2(h) (binding) | IRS-1(h) + crkII(h) <==> IRS-1(h):crkII(h) (binding) | 14-3-3epsilon(v.s.) + IRS-1(h) <==> 14-3-3epsilon(v.s.):IRS-1(h) (binding) | IL-4Ralpha(h){pY} + IRS-1(h) <==> IL-4Ralpha(h){pY}:IRS-1(h) (binding) | InsR(h){p} + IRS-1(h) <==> InsR(h){p}:IRS-1(h) (binding) | IRS-1(h) + Nck-2(h) <==> IRS-1(h):Nck-2(h) (binding) | IRS-1(h) + Nck-1(h) <==> IRS-1(h):Nck-1(h) (binding) | IRS-1(h) --Caspase-10(h)--> IRS-1-p16(h) + protein remnants (processing) | IRS-1(h) + NTP --Jak2(v.s.)--> IRS-1(h){pY} + NDP (phosphorylation) | IRS-1(h) + G-alpha-i2(h) <==> IRS-1(h):G-alpha-i2(h) (binding) | IRS-1(h) + ATP --> IRS-1(h){pY} + ADP (phosphorylation) | IRS-1(h) + ATP --IRAK1(m)--> IRS-1(h){p} + ADP (phosphorylation) | IRS-1(h) + IGF-1R(h) <==> IRS-1(h):IGF-1R(h) (binding) | IRS-1(h) + IRAK1(m) <==> IRS-1(h):IRAK1(m) (binding) | IRS-1(h) + p85(m) <==> IRS-1(h):p85(m) (binding) | Jak1(h) + IRS-1(h) <==> Jak1(h):IRS-1(h) (binding) | p85(h) + IRS-1(h) <==> p85(h):IRS-1(h) (binding) | Jak2(h) + IRS-1(h) <==> Jak2(h):IRS-1(h) (binding) | IRS-1(h) + 2 ATP --> IRS-1(h){pS312}{pS616} + 2 ADP (phosphorylation) | IRS-1(h) + 2 ATP --> IRS-1(h){pY612}{pY632} + 2 ADP (phosphorylation) | 14-3-3sigma(m.s.) + IRS-1(h) <==> 14-3-3sigma(m.s.):IRS-1(h) (binding) | IRS1(h) --> IRS-1(h) (expression). | IRS-1(h){pY} --PTP1B(h)--> IRS-1(h) + p (dephosphorylation) | IFNgamma(h) --/ IRS-1(h) (decrease of abundance) | ErbB1-p170(h){pY998} + IRS-1(h) <==> IRS-1(h):ErbB1-p170(h){pY998} (binding) | ErbB2(h){pY1221}{pY1222} + IRS-1(h) <==> ErbB2(h){pY1221}{pY1222}:IRS-1(h) (binding) | ErbB4(h) + IRS-1(h) <==> ErbB4(h):IRS-1(h) (binding) | IRS1(h) --> IRS-1(h) (expression). | IRS1(h) --> IRS1(h) (expression). | hsa-miR-145 --/ IRS1(h) (translational repression). | hsa-miR-126 --/ IRS1(h) (translational repression). |
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Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 3 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 46 | Phosphotyrosine. | Swiss-Prot 53.0 | 99 | Phosphoserine (by CK2) (By similarity). | Swiss-Prot 53.0 | 312 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 329 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 345 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 465 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 612 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 629 | Phosphoserine. | Swiss-Prot 53.0 | 632 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 636 | Phosphoserine. | Swiss-Prot 53.0 | 662 | Phosphotyrosine. | Swiss-Prot 53.0 | 794 | Phosphoserine (by SNF1LK2). | Swiss-Prot 53.0 | 896 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 941 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 989 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 1101 | Phosphoserine. | Swiss-Prot 53.0 | 1145 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1179 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 1223 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1229 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 307 | Phosphoserine (PKC delta;IK) | 12351658;14583092;16099428;15199052;16129690 | Phospho.ELM 6.0 | 662 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 | 46 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 | 896 | Phosphotyrosine | 11259577 | Phospho.ELM 6.0 | 794 | Phosphoserine (SIK) | 12624099 | Phospho.ELM 6.0 | 612 | Phosphotyrosine | 15001544 | Phospho.ELM 6.0 | 632 | Phosphotyrosine | 15001544 | Phospho.ELM 6.0 | 1101 | Phosphoserine (PKC theta) | 15364919;17081983 | Phospho.ELM 6.0 | 1223 | Phosphoserine | 16020478 | Phospho.ELM 6.0 | 1222 | Phosphoserine | 16020478 | Phospho.ELM 6.0 | 530 | Phosphothreonine | 16020478 | Phospho.ELM 6.0 | 892 | Phosphoserine | 16020478 | Phospho.ELM 6.0 | 374 | Phosphoserine | 16020478 | Phospho.ELM 6.0 | 348 | Phosphoserine | 16020478 | Phospho.ELM 6.0 | 1145 | Phosphoserine | 16020478 | Phospho.ELM 6.0 | 1078 | Phosphoserine | 16503154 | Phospho.ELM 6.0 | 616 | Phosphoserine (MAPK3) | 15001544;14769130 | Phospho.ELM 6.0 | 574 | Phosphoserine (PKC delta) | 15516986;14583092 | Phospho.ELM 6.0 | 636 | Phosphoserine | 14769130;16099428;15576463;16123357;17081983 | Phospho.ELM 6.0 | 639 | Phosphoserine | 14769130;16099428;15576463;16123357 | Phospho.ELM 6.0 | 323 | Phosphoserine (PKC zeta) | 15516986;14583092;16129678 | Phospho.ELM 6.0 | 629 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 227372219 - 227374219 | Agilent_014791 |
chr2 |
Promoter: 227372219 - 227374219 | GSE27584 |