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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

3667

Name

IRS1

Synonymous

insulin receptor substrate 1;IRS1;insulin receptor substrate 1

Definition

IRS-1

Position

2q36

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 CRKNCI_NATURE;

in same component

 GDNFNCI_NATURE;

in same component

 GFRA1NCI_NATURE;

in same component

 Gnb2IMID;

in same component

 IGF1NCI_NATURE;

in same component

 IGF1RIMID;

in same component

 IGF1RNCI_NATURE;

in same component

 IL2RGNCI_NATURE;

in same component

 IL4NCI_NATURE;

in same component

 IL4RNCI_NATURE;

in same component

 INSNCI_NATURE;

in same component

 INSRNCI_NATURE;

in same component

 JAK1NCI_NATURE;

in same component

 JAK3NCI_NATURE;

in same component

 NCK1IMID;

in same component

 NCK2NCI_NATURE;

in same component

 NTRK2IMID;

in same component

 PIK3CAIMID;

in same component

 PTK2IMID;

in same component

 PTPN11NCI_NATURE;

in same component

 PTPN1NCI_NATURE;

in same component

 RBP1IMID;

in same component

 SHC1NCI_NATURE;

in same component

 SOS1NCI_NATURE;

in same component

 YWHAHIMID;

interacts with

 AKT1BIOGRID;

interacts with

 AKT1HPRD;

interacts with

 ALKBIOGRID;

interacts with

 ALKHPRD;

interacts with

 AP3S1BIOGRID;

interacts with

 AP3S1HPRD;

interacts with

 ARHGAP20INTACT;

interacts with

 ASAP1INTACT;

interacts with

 ASAP2INTACT;

interacts with

 ATP2A2HPRD;

interacts with

 ATP2A3HPRD;

interacts with

 BCL2BIOGRID;

interacts with

 BCL2L1BIOGRID;

interacts with

 BCL2L1HPRD;

interacts with

 C11orf84INTACT;

interacts with

 CAV1HPRD;

interacts with

 CBLBBIOGRID;

interacts with

 CBLBINTACT;

interacts with

 CBLINTACT;

interacts with

 CD2APINTACT;

interacts with

 CDH1HPRD;

interacts with

 CHUKBIOGRID;

interacts with

 CHUKHPRD;

interacts with

 CRKHPRD;

interacts with

 CSKINTACT;

interacts with

 CSNK2A1HPRD;

interacts with

 CSNK2BHPRD;

interacts with

 CSRP1INTACT;

interacts with

 DIAPH1INTACT;

interacts with

 DNM1INTACT;

interacts with

 DOCK4INTACT;

interacts with

 DOCK5INTACT;

interacts with

 EGFRINTACT;

interacts with

 EGFRMINT;

interacts with

 ELMO2INTACT;

interacts with

 EPS15L1INTACT;

interacts with

 ERBB2MINT;

interacts with

 ERRFI1INTACT;

interacts with

 ESR1BIOGRID;

interacts with

 FAM59AINTACT;

interacts with

 FAM59BINTACT;

interacts with

 FERHPRD;

interacts with

 FESHPRD;

interacts with

 FGD6INTACT;

interacts with

 FRS2INTACT;

interacts with

 FYNHPRD;

interacts with

 GAB2INTACT;

interacts with

 GHRHPRD;

interacts with

 GIT1INTACT;

interacts with

 GRB10BIOGRID;

interacts with

 GRB14HPRD;

interacts with

 HDAC2BIOGRID;

interacts with

 HDGFRP3INTACT;

interacts with

 HGSINTACT;

interacts with

 HUNKINTACT;

interacts with

 IGF1RBIOGRID;

interacts with

 IGF1RHPRD;

interacts with

 IGF2BP1INTACT;

interacts with

 IKBKBBIOGRID;

interacts with

 IKBKBHPRD;

interacts with

 IL4RHPRD;

interacts with

 INPPL1INTACT;

interacts with

 INSRBIOGRID;

interacts with

 INSRHPRD;

interacts with

 INSRMINT;

interacts with

 IRS2BIOGRID;

interacts with

 IRS2INTACT;

interacts with

 IRS4INTACT;

interacts with

 JAK1BIOGRID;

interacts with

 JAK1HPRD;

interacts with

 JAK2BIOGRID;

interacts with

 JAK2HPRD;

interacts with

 JAK3BIOGRID;

interacts with

 JAK3HPRD;

interacts with

 KHDRBS1BIOGRID;

interacts with

 KHDRBS1INTACT;

interacts with

 MAP4K5INTACT;

interacts with

 MAPK1HPRD;

interacts with

 MAPK8BIOGRID;

interacts with

 MAPK8HPRD;

interacts with

 MAPK9HPRD;

interacts with

 MTORBIOGRID;

interacts with

 MTORHPRD;

interacts with

 MYCBPINTACT;

interacts with

 NCK2BIOGRID;

interacts with

 NCKAP1INTACT;

interacts with

 NISCHBIOGRID;

interacts with

 NISCHINTACT;

interacts with

 ODR4INTACT;

interacts with

 PDPK1HPRD;

interacts with

 PEAK1INTACT;

interacts with

 PHIPHPRD;

interacts with

 PIK3AP1INTACT;

interacts with

 PIK3C2BINTACT;

interacts with

 PIK3CABIOGRID;

interacts with

 PIK3CAINTACT;

interacts with

 PIK3CAMINT;

interacts with

 PIK3CBINTACT;

interacts with

 PIK3R1BIOGRID;

interacts with

 PIK3R1HPRD;

interacts with

 PIK3R1INTACT;

interacts with

 PIK3R1MINT;

interacts with

 PIK3R2HPRD;

interacts with

 PIK3R2INTACT;

interacts with

 PIK3R3BIOGRID;

interacts with

 PIK3R3HPRD;

interacts with

 PIK3R3INTACT;

interacts with

 PPM1BINTACT;

interacts with

 PPP1CAINTACT;

interacts with

 PPP5CINTACT;

interacts with

 PRKCDBIOGRID;

interacts with

 PRKCDHPRD;

interacts with

 PRKCGHPRD;

interacts with

 PRKCQHPRD;

interacts with

 PRKCZHPRD;

interacts with

 PrkczMINT;

interacts with

 PSTPIP2INTACT;

interacts with

 PTK2BIOGRID;

interacts with

 PTPLAD1INTACT;

interacts with

 PTPN11BIOGRID;

interacts with

 PTPN11HPRD;

interacts with

 PTPN11INTACT;

interacts with

 PTPN11MINT;

interacts with

 PTPN12INTACT;

interacts with

 PTPN1BIOGRID;

interacts with

 PTPN1HPRD;

interacts with

 PTPN1MINT;

interacts with

 PTPRCHPRD;

interacts with

 PTPRFHPRD;

interacts with

 RAD51HPRD;

interacts with

 RADILINTACT;

interacts with

 ROCK1HPRD;

interacts with

 RPTORHPRD;

interacts with

 SFNBIOGRID;

interacts with

 SFNMINT;

interacts with

 SH2D5INTACT;

interacts with

 SH3PXD2AINTACT;

interacts with

 SH3PXD2BINTACT;

interacts with

 SHC1BIOGRID;

interacts with

 SHC1HPRD;

interacts with

 SHC1INTACT;

interacts with

 SIK2HPRD;

interacts with

 SIRPAINTACT;

interacts with

 SLAIN2INTACT;

interacts with

 SLC25A13INTACT;

interacts with

 SLC25A5INTACT;

interacts with

 SLC25A6INTACT;

interacts with

 SOCS1BIOGRID;

interacts with

 SOCS1HPRD;

interacts with

 SOCS3HPRD;

interacts with

 SOS1INTACT;

interacts with

 SOS2INTACT;

interacts with

 STAMBPINTACT;

interacts with

 SYNJ1INTACT;

interacts with

 TECINTACT;

interacts with

 TSG101INTACT;

interacts with

 TTYH2INTACT;

interacts with

 TUBHPRD;

interacts with

 TYK2HPRD;

interacts with

 UBTFBIOGRID;

interacts with

 UBTFHPRD;

interacts with

 VAV3INTACT;

interacts with

 WASLINTACT;

interacts with

 WDR44INTACT;

interacts with

 WDR6INTACT;

interacts with

 WDR77INTACT;

interacts with

 WIPF1INTACT;

interacts with

 WIPF2INTACT;

interacts with

 WIPF3INTACT;

interacts with

 YWHABBIOGRID;

interacts with

 YWHABHPRD;

interacts with

 YWHABINTACT;

interacts with

 YWHAEBIOGRID;

interacts with

 YWHAEHPRD;

interacts with

 YWHAEINTACT;

interacts with

 YWHAEMINT;

interacts with

 YWHAGHPRD;

interacts with

 YWHAGINTACT;

interacts with

 YWHAHBIOGRID;

interacts with

 YWHAHINTACT;

interacts with

 YWHAQINTACT;

interacts with

 YWHAZHPRD;

interacts with

 YWHAZINTACT;

Metabolic Interaction   [Top]

There is no record for IRS1

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 CRKNCI_NATURE;

reacts with

 GDNFNCI_NATURE;

reacts with

 GFRA1NCI_NATURE;

reacts with

 Gnb2IMID;

reacts with

 IGF1NCI_NATURE;

reacts with

 IGF1RIMID;

reacts with

 IGF1RNCI_NATURE;

reacts with

 IL2RGNCI_NATURE;

reacts with

 IL4NCI_NATURE;

reacts with

 IL4RNCI_NATURE;

reacts with

 INPP5DNCI_NATURE;

reacts with

 INSNCI_NATURE;

reacts with

 INSRNCI_NATURE;

reacts with

 IRS1IMID;

reacts with

 IRS1NCI_NATURE;

reacts with

 JAK1NCI_NATURE;

reacts with

 JAK3NCI_NATURE;

reacts with

 NCK1IMID;

reacts with

 NCK2NCI_NATURE;

reacts with

 NTRK2IMID;

reacts with

 PIK3CAIMID;

reacts with

 PTK2IMID;

reacts with

 PTPN11NCI_NATURE;

reacts with

 PTPN1NCI_NATURE;

reacts with

 RBP1IMID;

reacts with

 SHC1NCI_NATURE;

reacts with

 SOS1NCI_NATURE;

reacts with

 YWHAHIMID;

state change

 FN1NCI_NATURE;

state change

 IGF1NCI_NATURE;

state change

 IGF1RNCI_NATURE;

state change

 INSRIMID;

state change

 IRS1NCI_NATURE;

state change

 ITGAVNCI_NATURE;

state change

 ITGB3NCI_NATURE;

state change

 MLST8NCI_NATURE;

state change

 MTORNCI_NATURE;

state change

 PRKCAIMID;

state change

 RPS6KB1NCI_NATURE;

state change

 RPTORNCI_NATURE;

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