| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3665 |
Name | IRF7 |
Synonymous | interferon regulatory factor 7;IRF7;interferon regulatory factor 7 |
Definition | IRF-7|interferon regulatory factor-7H |
Position | 11p15.5 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | TRAM(h) + IRF-7(h) <==> TRAM(h):IRF-7(h) (binding) | TRIF(h) + IRF-7(h) <==> TRIF(h):IRF-7(h) (binding) | IRF-7(h) + ATP --IKK-i(h){p}--> IRF-7(h){p} + ADP (phosphorylation) | IRF-7(h) + ATP --TBK1(h)--> IRF-7(h){p} + ADP (phosphorylation) | TIRAP(v.s.) + IRF-7(h) <==> TIRAP(v.s.):IRF-7(h) (binding) | IRF-7(h) --> IRF7(h) (DNA binding). | IRAK1(m.s.) + IRF-7(h) <==> IRAK1(m.s.):IRF-7(h) (binding) | MyD88(h) + IRF-7(h) <==> MyD88(h):IRF-7(h) (binding) | IRF-7(h) --> CCL19(h) (transactivation) | IRF-7(h) + TANK(h) <==> IRF-7(h):TANK(h) (binding) | IRF-7(h) + 2 ATP --> IRF-7(h){pS477}{pS479} + 2 ADP (phosphorylation) | IRF-7(h) --> ISG15(h) (DNA binding). | IRF-7(h) --> IFNA1(h) (transactivation) | IRF-7(h) --> IFNA4(h) (transactivation) | IRF-7(h) --> IL29(h) (transactivation) | IRF-7(h) --> IL28B(h) (transactivation) | IRF-7(h) --> IFNB1(h) (DNA binding). | IRF-7(h) --> IFNA14(h) (DNA binding). | IRF7(h) --> IRF-7(h) (expression). | IFNbeta(h) --> IRF-7(h) (increase of abundance) | IRF-7A(h) --> CCL5(h) (DNA binding). | IRF-7A(h) --> ISG15(h) (DNA binding; transactivation). | IRF-7A(h) --> IFNB1(h) (DNA binding; transactivation). | IRF7(h) --> IRF-7A(h) (expression). | IRF-7H(h) --> IFNA1(h) (DNA binding; transactivation). | IRF-7H(h) --> IFNA14(h) (DNA binding). | IRF7(h) --> IRF-7H(h) (expression). | IRF7(h) --> IRF-7B(h) (expression). | IRF7(h) --> IRF-7C(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 471 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 472 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 483 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 484 | Phosphoserine (By similarity). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr11 |
Promoter: 605988 - 606032 | Agilent_014791 |
chr11 |
Promoter: 605228 - 607228 | Agilent_014791 |
chr11 |
Promoter: 605499 - 607499 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 605499 - 607499 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 605228 - 607228 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 605228 - 607228 | GSE27584 |
chr11 |
Promoter: 605499 - 607499 | GSE27584 |
chr11 |
Promoter: 605499 - 607499 | GSE27584 |
chr11 |
Promoter: 605499 - 607499 | Agilent_014791_44K |
chr11 |
Promoter: 605499 - 607499 | PMID:16435073 |
chr11 |
Promoter: 605499 - 607499 | PMID:16435073 |
chr11 |
Promoter: 605228 - 607228 | PMID:16435073 |
chr11 |
Promoter: 605499 - 607499 | PMID:15367334 |
chr11 |
Promoter: 605499 - 607499 | PMID:15367334 |
chr11 |
Promoter: 605228 - 607228 | PMID:15367334 |