Entrez Gene

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General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information
Gene ID	3565
Name	IL4
Synonymous	interleukin 4;IL4;interleukin 4
Definition	B cell growth factor 1\|B_cell stimulatory factor 1\|binetrakin\|interleukin 4 variant 2\|interleukin-4\|lymphocyte stimulatory factor 1\|pitrakinra
Position	5q31.1
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
IL-4(h) + IL-4Ralpha(h) <==> IL-4(h):IL-4Ralpha(h) (binding)
IL-4(h) + IL-4Ralpha(h) + IL-13Ralpha1(h) <==> IL-4(h):IL-4Ralpha(h):IL-13Ralpha1(h) (binding)
IL-4(h) --> Jak1(h){pY} (increase of phosphorylation)
IL-4(h) --> Jak3(h){pY} (increase of phosphorylation)
IL-4(h) --> STAT6(h){pY} (increase of phosphorylation)
IL-4(h) --> JNK1(h){p} (increase of phosphorylation)
IL-4(h) --> p38alpha(h){p} (increase of phosphorylation)
IL-4(h) --> ERK(h){p} (increase of phosphorylation)
IL-4(h) --> CS1(h) (increase of abundance)
IL-4(h) --> STAT3(h){pY705} (increase of phosphorylation)
IL-4(h) --> CRP(h) (transactivation)
IL-4(h) --> IL-4(h) (expression).
IFNgamma(h) --> IL-4(h) (increase of secretion)
IL-4-isoform1(h) --> STAT6(h){pS}{pY} (increase of phosphorylation)
IL-4-isoform1(h) --> STAT6(mo){pS}{pT}{pY} (increase of phosphorylation)
IL-4(h) --> IL-4-isoform1(h) (expression).
IL-4(h) --> IL-4-isoform2(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
62	N-linked (GlcNAc...).		Swiss-Prot 53.0

Chromosome	Location	Source
Methylation Profile [Top]
chr5	Promoter: 132035772 - 132037772	GoldenGate_Methylation_Cancer_Panel_I
chr5	Promoter: 132035772 - 132037772	GoldenGate_Methylation_Cancer_Panel_I
chr5	Promoter: 132035772 - 132037772	GSE27584
chr5	Promoter: 132035772 - 132037772	GSE27584

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