| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3480 |
Name | IGF1R |
Synonymous | insulin-like growth factor 1 receptor;IGF1R;insulin-like growth factor 1 receptor |
Definition | IGF-I receptor|insulin-like growth factor I receptor|soluble IGF1R variant 1|soluble IGF1R variant 2 |
Position | 15q26.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IGF-1R(h) + GIPC1(m) <==> IGF-1R(h):GIPC1(m) (binding) | IGF-1R(h) + p85beta(m) <==> IGF-1R(h):p85beta(m) (binding) | IGF-1R(h) + GIPC1(h) <==> IGF-1R(h):GIPC1(h) (binding) | IGF-1R(h) + 14-3-3epsilon(v.s.) <==> IGF-1R(h):14-3-3epsilon(v.s.) (binding) | beta1-integrin(h) + IGF-1R(h) <==> beta1-integrin(h):IGF-1R(h) (binding) | IGF-1R(h) + p85(m.s.) <==> IGF-1R(h):p85(m.s.) (binding) | Shc-1(h) + IGF-1R(h) <==> Shc-1(h):IGF-1R(h) (binding) | IRS-1(h) + IGF-1R(h) <==> IRS-1(h):IGF-1R(h) (binding) | IGF-1R(h) + ATP --> IGF-1R(h){pY} + ADP (phosphorylation) | SOCS-2(h) + IGF-1R(h) <==> SOCS-2(h):IGF-1R(h) (binding) | IGF-1R(h) --PACE(h)--> IGF-1R-alpha-p130(h) + IGF-1R-beta-p97(h) (cleavage) | IGF-1R(h) + IGF-1(h) <==> IGF-1R(h):IGF-1(h) (binding) | IGF-1R(h) --trypsin-1(m.s.)--> IGF-1R-alpha-p130(h) + IGF-1R-beta-p97(h) + IGF-1R-beta-p102(h) (cleavage) | IGF-1R(h) + ATP --> IGF-1R(h){pY} + ADP (phosphorylation; automodification) | IGF-1R(h) --PACE(h)--> IGF-1R-beta-p97(h) + protein remnants (cleavage) | IGF-1R(h) --PC5a(m)--> IGF-1R-beta-p97(h) + protein remnants (cleavage) | IGF-2(m.s.) + IGF-1R(h) <==> IGF-2(m.s.):IGF-1R(h) (binding) | 14-3-3gamma(h) + IGF-1R(h) <==> 14-3-3gamma(h):IGF-1R(h) (binding) | ErbB1(h) + IGF-1R(h) <==> ErbB1(h):IGF-1R(h) (binding) | Src(h) + IGF-1R(h) <==> Src(h):IGF-1R(h) (binding) | IGF-1R(h) + 2 ATP --> IGF-1R(h){pY1161}{pY1346} + 2 ADP (phosphorylation) | IGF-1R(h) + PDK1(h){pS241} <==> IGF-1R(h):PDK1(h){pS241} (binding) | PDK1(h) + IGF-1R(h) <==> PDK1(h):IGF-1R(h) (binding) | IGF1R(h) --> IGF-1R(h) (expression). | atad2(h) --> IGF-1R(h) (increase of abundance) | IGF-1R(h) + ATP --> IGF-1R(h){pY} + ADP (phosphorylation; automodification) | IGF-1R(h) + PDK1-isoform1(h) <==> IGF-1R(h):PDK1-isoform1(h) (binding) | IGF1R(h) --> IGF-1R(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 51 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 102 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 135 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 244 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 314 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 417 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 438 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 534 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 607 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 622 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 640 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 747 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 756 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 764 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 900 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 913 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 980 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1161 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1165 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1166 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1346 | Phosphotyrosine (IGF1R) | 8550552 | Phospho.ELM 6.0 | 973 | Phosphotyrosine (IGF1R) | 8550552;8940173 | Phospho.ELM 6.0 | 1281 | Phosphotyrosine (IGF1R) | 8550552;8972223 | Phospho.ELM 6.0 | 1280 | Phosphotyrosine (IGF1R) | 8940173;8972223 | Phospho.ELM 6.0 | 980 | Phosphotyrosine (IGF1R) | 8550552;8940173;7537849;7559478 | Phospho.ELM 6.0 | 1161 | Phosphotyrosine (Src;IGF1R) | 8550552;8940173 | Phospho.ELM 6.0 | 1165 | Phosphotyrosine (Src;IGF1R) | 8550552;8940173 | Phospho.ELM 6.0 | 1166 | Phosphotyrosine (Src;IGF1R) | 8550552;8940173 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr15 |
Promoter: 97008784 - 97010784 | Agilent_014791 |
chr15 |
Promoter: 97008784 - 97010784 | GoldenGate_Methylation_Cancer_Panel_I |
chr15 |
Promoter: 97008784 - 97010784 | GSE27584 |