Entrez Gene

Basic Information
Gene ID	332
Name	BIRC5
Synonymous	baculoviral IAP repeat containing 5;BIRC5;baculoviral IAP repeat containing 5
Definition	apoptosis inhibitor 4\|apoptosis inhibitor survivin\|baculoviral IAP repeat-containing protein 5\|survivin variant 3 alpha
Position	17q25
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
Smac(h) + survivin(h) <==> Smac(h):survivin(h) (binding)
survivin(h) + Caspase-3(h) <==> survivin(h):Caspase-3(h) (binding)
survivin(h) + Caspase-7(h) <==> survivin(h):Caspase-7(h) (binding)
survivin(h) + RasGAP(h) <==> survivin(h):RasGAP(h) (binding)
INCENP(h) + survivin(h) + Aurora-B(h) <==> INCENP(h):survivin(h):Aurora-B(h) (binding)
Aurora-B(h) + survivin(h) <==> Aurora-B(h):survivin(h) (binding)
survivin(h) + ATP --Aurora-B(h)--> survivin(h){pT117} + ADP (phosphorylation)
Hsp90(h) + survivin(h) <==> Hsp90(h):survivin(h) (binding)
Hsp90(h) + tubulin(h) + survivin(h) <==> Hsp90(h):survivin(h):tubulin(h) (binding)
Hsp90-alpha(m.s.) + survivin(h) <==> Hsp90-alpha(m.s.):survivin(h) (binding)
survivin(h) + borealin(h) + Aurora-B(h) + INCENP-xbb1(h) <==> survivin(h):borealin(h):Aurora-B(h):INCENP-xbb1(h) (binding)
INCENP(h) + Aurora-B(h) + borealin(h) + survivin(h) <==> INCENP(h):Aurora-B(h):borealin(h):survivin(h) (binding)
borealin(h) + survivin(h) <==> borealin(h):survivin(h) (binding)
survivin(h) + Aurora-B(h) <==> survivin(h):Aurora-B(h) (binding)
survivin(h) + INCENP-I(c) <==> survivin(h):INCENP-I(c) (binding)
survivin(h) + Aurora-B(m.s.) <==> survivin(h):Aurora-B(m.s.) (binding)
survivin(h) + INCENP(m.s.) <==> survivin(h):INCENP(m.s.) (binding)
survivin(h) + borealin(h) + INCENP-xbb1(h) <==> survivin(h):borealin(h):INCENP-xbb1(h) (binding)
Evi5(h) + survivin(h) <==> Evi5(h):survivin(h) (binding)
Evi5(h) + survivin(h) <==> Evi5(h):survivin(h) (binding)
Evi5(h) + INCENP(h) + Aurora-B(h) + survivin(h) <==> Evi5(h):INCENP(h):Aurora-B(h):survivin(h) (binding)
survivin(h) + Fam(h) <==> survivin(h):Fam(h) (binding)
survivin(h) + n ubiquitin(h) --> survivin(h){ub{K48}(n)} (ubiquitination)
survivin(h) --> survivin(h) (translocation)
survivin(h) + ATP --> survivin(h){pT117} + ADP (phosphorylation)
USF2(h) + survivin(h) <==> USF2(h):survivin(h) (binding)
2 survivin(h) + 2 borealin(h) <==> (survivin(h))2:(borealin(h))2 (binding)
LC3B(h) + survivin(h) <==> LC3B(h):survivin(h) (binding)
survivin(h) + n ubiquitin(h) --> survivin(h){ub{K63}(n)} (ubiquitination)
hbxip(h) + survivin(h) <==> hbxip(h):survivin(h) (binding)
survivin(h) + ATP --> survivin(h){pT34} + ADP (phosphorylation)
BIRC5(h) --> survivin(h) (expression).
survivin(h) --> survivin(h) (translocation)
MCP-1(m.s.) --> survivin(h) (increase of abundance)
BIRC5(h) --> survivin-alpha(h) (expression).
BIRC5(h) --> survivin-beta(h) (expression).
BIRC5(h) --> survivin-isoform3(h) (expression).
BIRC5(h) --> survivin-isoform4(h) (expression).
BIRC5(h) --> survivin-isoform5(h) (expression).
BIRC5(h) --> survivin-isoform6(h) (expression).
BIRC5(h) --> survivin-isoform7(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
34	Phosphothreonine (by CDC2).		Swiss-Prot 53.0
117	Phosphothreonine (Aurora B)	14610074	Phospho.ELM 6.0
34	Phosphothreonine (CDK1)	11861764;11069302	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr17	Promoter: 73720372 - 73722372	Agilent_014791
chr17	Promoter: 73720372 - 73722372	GoldenGate_Methylation_Cancer_Panel_I
chr17	Promoter: 73720372 - 73722372	GoldenGate_Methylation_Cancer_Panel_I
chr17	Promoter: 73720372 - 73722372	GoldenGate_Methylation_Cancer_Panel_I
chr17	Promoter: 73720372 - 73722372	GSE27584
chr17	Promoter: 73720372 - 73722372	GSE27584
chr17	Promoter: 73720372 - 73722372	GSE27584
chr17	Promoter: 73720372 - 73722372	Agilent_014791_44K

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]