| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2475 |
Name | MTOR |
Synonymous | mechanistic target of rapamycin (serine/threonine kinase);MTOR;mechanistic target of rapamycin (serine/threonine kinase) |
Definition | FK506 binding protein 12-rapamycin associated protein 2|FK506-binding protein 12-rapamycin complex-associated protein 1|FKBP-rapamycin associated protein|FKBP12-rapamycin complex-associated protein 1|mammalian target of rapamycin|rapamycin and FKBP12 targ |
Position | 1p36.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | mTOR(h) + raptor(h) <==> mTOR(h):raptor(h) (binding) | mTOR(h) + mLST8(h) <==> mTOR(h):mLST8(h) (binding) | mTOR(h) + rictor(h) <==> mTOR(h):rictor(h) (binding) | mLST8(h) + mTOR(h) + rictor(h) <==> mLST8(h):mTOR(h):rictor(h) (binding) | mLST8(h) + mTOR(h) + raptor(h) <==> mLST8(h):mTOR(h):raptor(h) (binding) | SIN1(h) + rictor(h) + mTOR(h) <==> SIN1(h):rictor(h):mTOR(h) (binding) | Protor-1-isoform3(h) + mTOR(h) <==> Protor-1-isoform3(h):mTOR(h) (binding) | Protor-1(h) + mTOR(h) <==> Protor-1(h):mTOR(h) (binding) | mTOR(h) + Protor-1(h) + rictor(h) <==> mTOR(h):Protor-1(h):rictor(h) (binding) | mTOR(h) + rictor(m.s.) <==> mTOR(h):rictor(m.s.) (binding) | mTOR(h) + raptor(m.s.) <==> mTOR(h):raptor(m.s.) (binding) | mTOR(h) + Protor-1-isoform1(h) <==> mTOR(h):Protor-1-isoform1(h) (binding) | mTOR(h) --> PDGFRB(h) (transactivation) | mTOR(h) + SIN1(h) <==> mTOR(h):SIN1(h) (binding) | SIN1-isoform1(h) + mTOR(h) <==> SIN1-isoform1(h):mTOR(h) (binding) | mTOR(h) + ATP --> mTOR(h){pS2448} + ADP (phosphorylation) | mTOR(h) --> p70S6K1(h){pT389} (increase of phosphorylation) | mTOR(h) --> p70S6K1(h){pT} (increase of phosphorylation) | mTOR(h) --> rps6(h){pS} (increase of phosphorylation) | mTOR(h) --> 4E-BP1(h){pT} (increase of phosphorylation) | mTOR(h) --> AKT(h){pS473} (increase of phosphorylation) | mTOR(h) --> PKCalpha(h){p} (increase of phosphorylation) | mTOR(h) --> AKT-1(m.s.){p} (increase of phosphorylation) | mTOR(h) + rictor(h) + mLST8(h) + SIN1(h) + Protor-1(h) <==> mTOR(h):rictor(h):mLST8(h):SIN1(h):Protor-1(h) (binding) | mTOR(h) + raptor(h) + mLST8(h) <==> mTOR(h):raptor(h):mLST8(h) (binding) | mTOR(h) + ATP --> mTOR(h){p} + ADP (phosphorylation; automodification) | MTOR(h) --> mTOR(h) (expression). | YB-1(h) --> mTOR(h) (increase of abundance) | RIG1(m.s.) --/ mTOR(h) (decrease of abundance) | raptor(h):p70S6K1(r) + ATP --mTOR(h)--> p70S6K1(r){p} + raptor(h) + ADP (phosphorylation; dissociation) | raptor(h):4E-BP1(h) + ATP --mTOR(h)--> 4E-BP1(h){p} + raptor(h) + ADP (phosphorylation; dissociation) | 4E-BP1(h) + NTP --mTOR(h)--> 4E-BP1(h){p} + NDP (phosphorylation) | 4E-BP1(h) + ATP --mTOR(h)--> 4E-BP1(h){pS65} + ADP (phosphorylation) | ATG13(m.s.) + ATP --mTOR(h)--> ATG13(m.s.){p} + ADP (phosphorylation) | ulk1(m.s.) + ATP --mTOR(h)--> ulk1(m.s.){p} + ADP (phosphorylation) | ulk2(m.s.) + ATP --mTOR(h)--> ulk2(m.s.){p} + ADP (phosphorylation) | ulk1(m) + ATP --mTOR(h)--> ulk1(m){p} + ADP (phosphorylation) | ATG13(h) + ATP --mTOR(h)--> ATG13(h){p} + ADP (phosphorylation) | AKT-1(m.s.) + ATP --mTOR(h)--> AKT-1(m.s.){p} + ADP (phosphorylation) | Protor-1(h) + mTOR(h) + rictor(m.s.) <==> Protor-1(h):mTOR(h):rictor(m.s.) (binding) | MTOR(h) --> mTOR(h) (expression). | ATG13(m.s.) + ATP --mTOR(h)--> ATG13(m.s.){p} + ADP (phosphorylation) | ulk1(m) + ATP --mTOR(h)--> ulk1(m){p} + ADP (phosphorylation) |
|---|
Post Transcriptional Modification [Top] | |||
There is no record for MTOR | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 11244651 - 11246651 | GSE27584 |
chr1 |
Promoter: 11244651 - 11246651 | Agilent_014791_44K |
chr1 |
Promoter: 11244651 - 11246651 | Agilent_014791 |