| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 1432 |
Name | MAPK14 |
Synonymous | mitogen-activated protein kinase 14;MAPK14;mitogen-activated protein kinase 14 |
Definition | CSAID-binding protein|Csaids binding protein|MAP kinase 14|MAP kinase Mxi2|MAP kinase p38 alpha|MAX-interacting protein 2|cytokine suppressive anti-inflammatory drug binding protein|cytokine suppressive anti-inflammatory drug-binding protein|mitogen-activ |
Position | 6p21.3-p21.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | p38alpha(h) + Max(h) <==> p38alpha(h):Max(h) (binding) | p38alpha(h) + CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2 <==> p38alpha(h):CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2 (binding) | Cdc25B(h) + p38alpha(h) <==> Cdc25B(h):p38alpha(h) (binding) | Cdc25C(h) + p38alpha(h) <==> Cdc25C(h):p38alpha(h) (binding) | p38alpha(h) + JLP(m) <==> p38alpha(h):JLP(m) (binding) | MKP-5(h) + p38alpha(h) <==> MKP-5(h):p38alpha(h) (binding) | p38alpha(h) + ATP --MKK6(h){p}--> p38alpha(h){p} + ADP (phosphorylation) | MKK6(h) + p38alpha(h) <==> MKK6(h):p38alpha(h) (binding) | MKK3(h) + p38alpha(h) <==> MKK3(h):p38alpha(h) (binding) | p38alpha(h) + Mnk1(m) <==> p38alpha(h):Mnk1(m) (binding) | TAB1(h) + p38alpha(h) <==> TAB1(h):p38alpha(h) (binding) | p38alpha(h) + proCaspase-8(h) <==> p38alpha(h):proCaspase-8(h) (binding) | p38alpha(h) + proCaspase-3(h) <==> p38alpha(h):proCaspase-3(h) (binding) | PTP-SL(m) + p38alpha(h) <==> PTP-SL(m):p38alpha(h) (binding) | STEP(r) + p38alpha(h) <==> STEP(r):p38alpha(h) (binding) | p38alpha(h) + ATP --> p38alpha(h){p} + ADP (phosphorylation) | TAB1(m.s.) + p38alpha(h) <==> TAB1(m.s.):p38alpha(h) (binding) | p38alpha(h) + ATP --MEKK3(h)--> p38alpha(h){p} + ADP (phosphorylation) | p38alpha(h) + MSK1(h) <==> p38alpha(h):MSK1(h) (binding) | p38alpha(h) --> MIP1A(h):CKR-5(h) (increase of binding) | p38alpha(h) --> VDR(h) (increase of abundance) | zfp36l1(h) + p38alpha(h) <==> zfp36l1(h):p38alpha(h) (binding) | p38alpha(h) + 2 ATP --> p38alpha(h){pT180}{pY182} + 2 ADP (phosphorylation) | p38alpha(h) + ubiquitin(m.s.) --> p38alpha(h){ub} (ubiquitination) | Keratin-8(h) + p38alpha(h) <==> Keratin-8(h):p38alpha(h) (binding) | p38alpha(h):Max(h) + ATP --> p38alpha(h) + Max(h){p} + ADP (phosphorylation; dissociation) | MAPK14(h) --> p38alpha(h) (expression). | Cdc25B(h):p38alpha(h) + ATP --> Cdc25B(h){p} + p38alpha(h) + ADP (phosphorylation; dissociation) | Cdc25C(h):p38alpha(h) + ATP --> Cdc25C(h){p} + p38alpha(h) + ADP (phosphorylation; dissociation) | p38alpha(h){p} --MKP-5(h)--> p38alpha(h) + p (dephosphorylation) | p38alpha(h){pT180}{pY182} --Wip1(m.s.)--> p38alpha(h) + 2 p (dephosphorylation) | p38alpha(h){pT180}{pY182} --PP2Calpha(m.s.)--> p38alpha(h) + 2 p (dephosphorylation) | p38alpha(h){pT180}{pY182} --PP2A(m.s.)--> p38alpha(h) + 2 p (dephosphorylation) | STAT1(h) + ATP --p38alpha(h)--> STAT1(h){pS727} + ADP (phosphorylation) | ATF-2-xbb4(h) + ATP --p38alpha(h)--> ATF-2-xbb4(h){p} + ADP (phosphorylation) | MSK1(h) + ATP --p38alpha(h)--> MSK1(h){p} + ADP (phosphorylation) | MAPKAPK2(h) + ATP --p38alpha(h)--> MAPKAPK2(h){p} + ADP (phosphorylation) | ATF-2(v.s.) + ATP --p38alpha(h)--> ATF-2(v.s.){p} + ADP (phosphorylation) | c-Fos(m) + ATP --p38alpha(h)--> c-Fos(m){pT325}{pT331} + ADP (phosphorylation) | TAB1(h) + 3 ATP --p38alpha(h)--> TAB1(h){pS423}{pT431}{pS438} + 3 ADP (phosphorylation) | PPARalpha(m) + 3 ATP --p38alpha(h)--> PPARalpha(m){pS6}{pS12}{pS21} + 3 ADP (phosphorylation) | ATF-2-isoform1(h) + ATP --p38alpha(h)--> ATF-2-isoform1(h){pT71} + ADP (phosphorylation) | MAPK14(h) --> CSBP1(h) (expression). | MAPK14(h) --> CSBP2(h) (expression). | MAPK14(h) --> EXIP(h) (expression). | MAPK14(h) --> Mxi2(h) (expression). | MAPK14(h) --> MAPK14_1(h) (expression). | hsa-miR-24 --/ MAPK14_1(h) (predicted) | MAPK14(h) --> MAPK14_2(h) (expression). | hsa-miR-24 --/ MAPK14_2(h) (predicted) | MAPK14(h) --> MAPK14_3(h) (expression). | MAPK14(h) --> MAPK14_4(h) (expression). |
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Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 180 | Phosphothreonine. | Swiss-Prot 53.0 | 182 | Phosphotyrosine. | Swiss-Prot 53.0 | 179 | Phosphothreonine (MAP2K3;MAP2K) | 7750576;16083285;15674326;15735648;10781613;159722 | Phospho.ELM 6.0 | 181 | Phosphotyrosine (MAP2K3;MAP2K) | 15592455;16083285;15659558;15674326;10781613;15972 | Phospho.ELM 6.0 | 322 | Phosphotyrosine (ZAP70) | 15735648 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr6 |
Promoter: 36102051 - 36104051 | GoldenGate_Methylation_Cancer_Panel_I |
chr6 |
Promoter: 36102051 - 36104051 | GoldenGate_Methylation_Cancer_Panel_I |
chr6 |
Promoter: 36102051 - 36104051 | GoldenGate_Methylation_Cancer_Panel_I |
chr6 |
Promoter: 36102051 - 36104051 | GoldenGate_Methylation_Cancer_Panel_I |
chr6 |
Promoter: 36102051 - 36104051 | GSE27584 |
chr6 |
Promoter: 36102051 - 36104051 | GSE27584 |
chr6 |
Promoter: 36102051 - 36104051 | GSE27584 |
chr6 |
Promoter: 36102051 - 36104051 | GSE27584 |
chr6 |
Promoter: 36102051 - 36104051 | Agilent_014791_44K |