Entrez Gene

Basic Information
Gene ID	1432
Name	MAPK14
Synonymous	mitogen-activated protein kinase 14;MAPK14;mitogen-activated protein kinase 14
Definition	CSAID-binding protein\|Csaids binding protein\|MAP kinase 14\|MAP kinase Mxi2\|MAP kinase p38 alpha\|MAX-interacting protein 2\|cytokine suppressive anti-inflammatory drug binding protein\|cytokine suppressive anti-inflammatory drug-binding protein\|mitogen-activ
Position	6p21.3-p21.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.194C>T; p.A65V; 6:36052776-36052776	prostate	carcinoma	Substitution - Missense
c.864G>T; p.M288I; 6:36107477-36107477	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.153A>G; p.A51A; 6:36052735-36052735	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.310C>T; p.L104L; 6:36072877-36072877	breast	carcinoma	Substitution - coding silent
c.218G>A; p.R73Q; 6:36052800-36052800	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.30G>C; p.R10R; 6:36028187-36028187	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.216G>A; p.L72L; 6:36052798-36052798	bone; fibula	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.802A>T; p.M268L; 6:36102610-36102610	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.937G>A; p.D313N; 6:36107550-36107550	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.937G>A; p.D313N; 6:36107550-36107550	liver	carcinoma	Substitution - Missense
c.937G>A; p.D313N; 6:36107550-36107550	liver	carcinoma	Substitution - Missense
c.362A>C; p.K121T; 6:36072929-36072929	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.472G>A; p.V158M; 6:36074073-36074073	breast	carcinoma	Substitution - Missense
c.472G>A; p.V158M; 6:36074073-36074073	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.152C>T; p.A51V; 6:36052734-36052734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.152C>T; p.A51V; 6:36052734-36052734	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.152C>T; p.A51V; 6:36052734-36052734	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.152C>T; p.A51V; 6:36052734-36052734	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.152C>T; p.A51V; 6:36052734-36052734	stomach	adenocarcinoma	Substitution - Missense
c.264C>T; p.D88D; 6:36059306-36059306	stomach	adenocarcinoma	Substitution - coding silent
c.887G>T; p.R296I; 6:36107500-36107500	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.370G>A; p.D124N; 6:36072937-36072937	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.633C>T; p.C211C; 6:36076559-36076559	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.633C>T; p.C211C; 6:36076559-36076559	liver	carcinoma	Substitution - coding silent
c.403C>A; p.L135I; 6:36072970-36072970	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.430G>A; p.A144T; 6:36073703-36073703	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.642C>T; p.A214A; 6:36076568-36076568	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.448-1G>T; p.?; 6:36074048-36074048	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.723_724insC; p.A244fs*5; 6:36100228-36100229	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.106_107GG>AA; p.G36N; 6:36028263-36028264	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.515C>T; p.A172V; 6:36075867-36075867	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.557G>A; p.R186K; 6:36075909-36075909	skin	malignant_melanoma	Substitution - Missense
c.965C>G; p.P322R; 6:36107578-36107578	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.965C>G; p.P322R; 6:36107578-36107578	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.744C>T; p.N248N; 6:36100249-36100249	ovary	other; neoplasm	Substitution - coding silent
c.491T>C; p.L164P; 6:36074092-36074092	ovary	carcinoma	Substitution - Missense
c.427delT; p.S143fs*4; 6:36073700-36073700	urinary_tract; bladder	carcinoma	Deletion - Frameshift
c.27C>A; p.Y9*; 6:36028184-36028184	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - Nonsense
c.797C>T; p.P266L; 6:36102605-36102605	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.200G>T; p.R67I; 6:36052782-36052782	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.244A>C; p.N82H; 6:36052826-36052826	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.117-2A>G; p.?; 6:36052697-36052697	skin	malignant_melanoma	Unknown
c.474G>A; p.V158V; 6:36074075-36074075	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.837C>T; p.P279P; 6:36102645-36102645	skin	malignant_melanoma	Substitution - coding silent
c.896C>T; p.A299V; 6:36107509-36107509	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.284C>T; p.S95F; 6:36059326-36059326	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.407G>A; p.R136Q; 6:36072974-36072974	skin; mucosal	malignant_melanoma	Substitution - Missense
c.813G>A; p.A271A; 6:36102621-36102621	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.246+-126delAATGGTGGGTTTTTTCCCTTTTTTCTCCTTAGTGCT; p.?; 6:36052667-36052702	skin	malignant_melanoma	Unknown
c.246+-126delAATGGTGGGTTTTTTCCCTTTTTTCTCCTTAGTGCT; p.?; 6:36052667-36052702	skin	malignant_melanoma	Unknown
c.683-1G>A; p.?; 6:36100187-36100187	urinary_tract; bladder	carcinoma	Unknown
c.281G>A; p.R94K; 6:36059323-36059323	skin	malignant_melanoma	Substitution - Missense
c.815A>C; p.N272T; 6:36102623-36102623	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.217C>T; p.R73W; 6:36052799-36052799	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.921C>T; p.Y307Y; 6:36107534-36107534	kidney	other; neoplasm	Substitution - coding silent
c.195G>A; p.A65A; 6:36052777-36052777	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.351G>C; p.V117V; 6:36072918-36072918	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.145_162del18; p.R49_K54delRVAVKK; 6:36052727-36052744	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.724_725insC; p.A244fs*5; 6:36100229-36100230	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Insertion - Frameshift
c.339G>T; p.L113L; 6:36072906-36072906	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.142T>A; p.L48I; 6:36052724-36052724	skin	malignant_melanoma	Substitution - Missense
c.329G>C; p.G110A; 6:36072896-36072896	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.572C>A; p.P191H; 6:36075924-36075924	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.971A>C; p.D324A; 6:36107584-36107584	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.116+10G>A; p.?; 6:36028283-36028283	ovary	other; neoplasm	Unknown
c.378T>C; p.H126H; 6:36072945-36072945	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.833A>T; p.N278I; 6:36102641-36102641	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.168C>T; p.S56S; 6:36052750-36052750	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.833A>G; p.N278S; 6:36102641-36102641	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.833A>G; p.N278S; 6:36102641-36102641	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.405C>T; p.L135L; 6:36072972-36072972	skin	malignant_melanoma	Substitution - coding silent
c.1073_1074insT; p.M358fs*>4; 6:36108437-36108438	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Insertion - Frameshift
c.1073T>A; p.M358K; 6:36108437-36108437	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]