Entrez Gene

Basic Information
Gene ID	11073
Name	TOPBP1
Synonymous	topoisomerase (DNA) II binding protein 1;TOPBP1;topoisomerase (DNA) II binding protein 1
Definition	DNA topoisomerase 2-binding protein 1\|DNA topoisomerase II-beta-binding protein 1\|DNA topoisomerase II-binding protein 1
Position	3q22.1
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
TOP2BP1(h) + ATP --AKT(m.s.)--> TOP2BP1(h){pS1159} + ADP (phosphorylation)
2 TOP2BP1(h) <==> (TOP2BP1(h))2 (binding)
TOPBP1(h) --> TOP2BP1(h) (expression).
Rad9a(h) + TOP2BP1(h) <==> Rad9a(h):TOP2BP1(h) (binding)
TOP2BP1(h) + HDAC1(h) <==> TOP2BP1(h):HDAC1(h) (binding)
Rad50(h) + TOP2BP1(h) + brca1(h) + BARD1(h) <==> Rad50(h):TOP2BP1(h):brca1(h):BARD1(h) (binding)
BARD1(h) + NBS1(h) + TOP2BP1(h) + brca1(h) <==> BARD1(h):NBS1(h):TOP2BP1(h):brca1(h) (binding)
Mre11(h) + NBS1(h) + Bach1(h) + Rad50(h) + TOP2BP1(h) + BARD1(h) <==> Mre11(h):NBS1(h):Bach1(h):Rad50(h):TOP2BP1(h):BARD1(h) (binding)
brca1(h) + TOP2BP1(h) <==> brca1(h):TOP2BP1(h) (binding)
TOP2BP1(h) + BARD1(h) <==> TOP2BP1(h):BARD1(h) (binding)
Bach1(h) + TOP2BP1(h) + brca1(h) + BARD1(h) <==> Bach1(h):TOP2BP1(h):brca1(h):BARD1(h) (binding)
MLH1(h) + TOP2BP1(h) + Bach1(h) + brca1(h) <==> MLH1(h):TOP2BP1(h):Bach1(h):brca1(h) (binding)
brca1(h) + TOP2BP1(h) <==> brca1(h):TOP2BP1(h) (binding)
Bach1(m.s.) + TOP2BP1(h) <==> Bach1(m.s.):TOP2BP1(h) (binding)
E2F-1(h){p} + TOP2BP1(h) <==> E2F-1(h){p}:TOP2BP1(h) (binding)
TOP2BP1(h) + ATP --> TOP2BP1(h){pS1159} + ADP (phosphorylation)
TOP2BP1(h) + E2F-1(h) <==> TOP2BP1(h):E2F-1(h) (binding)
TOPBP1(h) --> TOP2BP1(h) (expression).

Location (AA)	PTM type	Database
Post Transcriptional Modification [Top]
805	Phosphoserine.	Swiss-Prot 53.0
888	Phosphoserine.	Swiss-Prot 53.0

Transcription Factors [Top]