Entrez Gene

Basic Information
Gene ID	9448
Name	MAP4K4
Synonymous	mitogen-activated protein kinase kinase kinase kinase 4;MAP4K4;mitogen-activated protein kinase kinase kinase kinase 4
Definition	HPK/GCK-like kinase HGK\|MAPK/ERK kinase kinase kinase 4\|MEK kinase kinase 4\|Ste20 group protein kinase HGK\|epididymis secretory protein Li 31\|hepatocyte progenitor kinase-like/germinal center kinase-like kinase\|nck-interacting kinase
Position	2q11.2-q12
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.2246T>C; p.L749P; 2:101866469-101866469	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1219C>T; p.R407*; 2:101844297-101844297	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1061G>A; p.R354Q; 2:101844139-101844139	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3770delG; p.G1258fs*5; 2:101888826-101888826	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1100C>T; p.S367F; 2:101844178-101844178	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2540delC; p.S847fs*37; 2:101869698-101869698	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.1215G>C; p.Q405H; 2:101844293-101844293	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2210T>G; p.I737S; 2:101866433-101866433	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.531G>T; p.Q177H; 2:101831743-101831743	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2396delA; p.N800fs*3; 2:101867251-101867251	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.587C>T; p.A196V; 2:101831799-101831799	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1539G>A; p.Q513Q; 2:101859699-101859699	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1145G>T; p.R382L; 2:101844223-101844223	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.155C>T; p.A52V; 2:101790751-101790751	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.3175G>A; p.V1059I; 2:101877128-101877128	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2341C>T; p.R781C; 2:101866564-101866564	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.3389C>T; p.A1130V; 2:101885247-101885247	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2136C>G; p.S712S; 2:101864968-101864968	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3879+4A>G; p.?; 2:101888939-101888939	pancreas	carcinoid-endocrine_tumour	Unknown
c.1928C>T; p.S643F; 2:101863882-101863882	skin	malignant_melanoma	Substitution - Missense
c.1928C>T; p.S643F; 2:101863882-101863882	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1625_1656del32; p.P542fs*12; 2:101859785-101859816	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.375C>T; p.L125L; 2:101825387-101825387	breast	carcinoma	Substitution - coding silent
c.3820G>A; p.G1274S; 2:101888876-101888876	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.89T>C; p.V30A; 2:101698504-101698504	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.60T>C; p.D20D; 2:101698475-101698475	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.813G>A; p.V271V; 2:101839858-101839858	breast	carcinoma	Substitution - coding silent
c.2998C>T; p.R1000C; 2:101874201-101874201	skin	malignant_melanoma	Substitution - Missense
c.2998C>T; p.R1000C; 2:101874201-101874201	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2998C>T; p.R1000C; 2:101874201-101874201	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3768C>A; p.G1256G; 2:101888824-101888824	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2891G>A; p.C964Y; 2:101874094-101874094	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Substitution - Missense
c.2050A>G; p.T684A; 2:101864004-101864004	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2784C>T; p.L928L; 2:101873670-101873670	skin	malignant_melanoma	Substitution - coding silent
c.2932C>T; p.R978W; 2:101874135-101874135	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2932C>T; p.R978W; 2:101874135-101874135	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2932C>T; p.R978W; 2:101874135-101874135	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.90_91GG>AT; p.V31F; 2:101698505-101698506	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1026C>T; p.S342S; 2:101844104-101844104	liver	carcinoma	Substitution - coding silent
c.1026C>T; p.S342S; 2:101844104-101844104	liver	carcinoma	Substitution - coding silent
c.1795C>T; p.R599*; 2:101860915-101860915	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3270G>A; p.E1090E; 2:101882627-101882627	skin	malignant_melanoma	Substitution - coding silent
c.2881G>A; p.G961R; 2:101874084-101874084	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1989A>C; p.P663P; 2:101863943-101863943	breast	carcinoma	Substitution - coding silent
c.2079T>G; p.S693R; 2:101864033-101864033	skin	malignant_melanoma	Substitution - Missense
c.2727C>G; p.T909T; 2:101870382-101870382	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.3332A>C; p.K1111T; 2:101885190-101885190	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1840G>A; p.A614T; 2:101860960-101860960	liver	carcinoma	Substitution - Missense
c.1961A>C; p.H654P; 2:101863915-101863915	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1961A>C; p.H654P; 2:101863915-101863915	breast	carcinoma	Substitution - Missense
c.109G>T; p.G37*; 2:101698524-101698524	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1943C>G; p.S648C; 2:101863897-101863897	skin	malignant_melanoma	Substitution - Missense
c.3439G>T; p.E1147*; 2:101887097-101887097	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.552G>A; p.R184R; 2:101831764-101831764	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.776C>T; p.S259L; 2:101839821-101839821	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.776C>T; p.S259L; 2:101839821-101839821	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2390G>A; p.R797H; 2:101867245-101867245	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.776C>T; p.S259L; 2:101839821-101839821	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.241A>C; p.N81H; 2:101823988-101823988	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.776C>T; p.S259L; 2:101839821-101839821	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.776C>T; p.S259L; 2:101839821-101839821	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.776C>T; p.S259L; 2:101839821-101839821	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.51C>T; p.S17S; 2:101698131-101698131	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.183T>C; p.D61D; 2:101823930-101823930	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2752G>C; p.V918L; 2:101870407-101870407	skin; extremity	malignant_melanoma	Substitution - Missense
c.1796G>A; p.R599Q; 2:101860916-101860916	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3858C>A; p.F1286L; 2:101888914-101888914	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2926C>T; p.P976S; 2:101874129-101874129	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2058G>T; p.K686N; 2:101864012-101864012	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3393G>T; p.W1131C; 2:101885251-101885251	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.673G>C; p.E225Q; 2:101834442-101834442	thyroid	carcinoma	Substitution - Missense
c.1996C>A; p.R666S; 2:101863950-101863950	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2207G>T; p.S736I; 2:101866430-101866430	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.140C>T; p.T47M; 2:101790736-101790736	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454C>G; p.R152G; 2:101829540-101829540	skin	malignant_melanoma	Substitution - Missense
c.2688G>T; p.M896I; 2:101870343-101870343	liver	carcinoma	Substitution - Missense
c.2688G>T; p.M896I; 2:101870343-101870343	liver	carcinoma	Substitution - Missense
c.498G>A; p.E166E; 2:101829584-101829584	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.149T>A; p.L50*; 2:101790745-101790745	skin	malignant_melanoma	Substitution - Nonsense
c.3023C>T; p.S1008F; 2:101874226-101874226	skin	malignant_melanoma	Substitution - Missense
c.416_417GG>AA; p.R139K; 2:101825428-101825429	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3667G>T; p.V1223F; 2:101887865-101887865	breast	carcinoma	Substitution - Missense
c.1522G>A; p.E508K; 2:101859682-101859682	urinary_tract; bladder	carcinoma	Substitution - Missense
c.643G>A; p.D215N; 2:101834412-101834412	breast	carcinoma	Substitution - Missense
c.401C>T; p.S134F; 2:101825413-101825413	skin	malignant_melanoma	Substitution - Missense
c.2738A>T; p.E913V; 2:101870393-101870393	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2738A>T; p.E913V; 2:101870393-101870393	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3639G>A; p.E1213E; 2:101887837-101887837	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.919G>T; p.D307Y; 2:101839964-101839964	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.789delT; p.F263fs*4; 2:101839834-101839834	stomach	carcinoma; adenocarcinoma	Deletion - Frameshift
c.789delT; p.F263fs*4; 2:101839834-101839834	stomach	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1626G>A; p.P542P; 2:101859786-101859786	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1626G>A; p.P542P; 2:101859786-101859786	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2204+1G>A; p.?; 2:101865037-101865037	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.2179C>G; p.Q727E; 2:101865011-101865011	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2179C>G; p.Q727E; 2:101865011-101865011	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1626G>A; p.P542P; 2:101859786-101859786	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2179C>G; p.Q727E; 2:101865011-101865011	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1596C>T; p.H532H; 2:101859756-101859756	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.874C>T; p.Q292*; 2:101839919-101839919	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1500G>T; p.E500D; 2:101859660-101859660	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2882G>C; p.G961A; 2:101874085-101874085	breast	carcinoma	Substitution - Missense
c.1396-9G>A; p.?; 2:101858987-101858987	pancreas	carcinoma	Unknown
c.592G>A; p.E198K; 2:101831804-101831804	breast	carcinoma	Substitution - Missense
c.1620A>G; p.P540P; 2:101859780-101859780	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.3177C>G; p.V1059V; 2:101877130-101877130	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.2988C>A; p.T996T; 2:101874191-101874191	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2901G>A; p.M967I; 2:101874104-101874104	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2511G>A; p.R837R; 2:101869669-101869669	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2879-2A>C; p.?; 2:101874080-101874080	skin	malignant_melanoma	Unknown
c.1246G>C; p.E416Q; 2:101855989-101855989	breast	carcinoma	Substitution - Missense
c.1282C>T; p.R428*; 2:101856025-101856025	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.494C>T; p.A165V; 2:101829580-101829580	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3344T>A; p.I1115N; 2:101885202-101885202	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3416T>G; p.F1139C; 2:101885274-101885274	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1188G>T; p.Q396H; 2:101844266-101844266	prostate	carcinoma	Substitution - Missense
c.737C>T; p.P246L; 2:101835942-101835942	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2082C>T; p.D694D; 2:101864036-101864036	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3416T>G; p.F1139C; 2:101885274-101885274	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2725A>G; p.T909A; 2:101870380-101870380	skin	malignant_melanoma	Substitution - Missense
c.1617G>A; p.P539P; 2:101859777-101859777	breast	carcinoma	Substitution - coding silent
c.3749G>A; p.R1250Q; 2:101888805-101888805	oesophagus	carcinoma	Substitution - Missense
c.2335G>A; p.G779R; 2:101866558-101866558	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1731C>T; p.N577N; 2:101860851-101860851	skin	malignant_melanoma	Substitution - coding silent
c.128G>A; p.R43Q; 2:101790724-101790724	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1060C>T; p.R354*; 2:101844138-101844138	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Nonsense
c.144T>C; p.G48G; 2:101790740-101790740	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2598G>A; p.G866G; 2:101869756-101869756	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.227A>T; p.Y76F; 2:101823974-101823974	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.3506A>G; p.Y1169C; 2:101887164-101887164	central_nervous_system; brain	glioma	Substitution - Missense
c.3546A>G; p.S1182S; 2:101887204-101887204	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1711G>A; p.D571N; 2:101860831-101860831	breast	carcinoma	Substitution - Missense
c.3707T>C; p.V1236A; 2:101887905-101887905	skin	malignant_melanoma	Substitution - Missense
c.3898C>T; p.R1300W; 2:101891184-101891184	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3898C>T; p.R1300W; 2:101891184-101891184	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3113A>C; p.K1038T; 2:101877066-101877066	large_intestine; colon	NS	Substitution - Missense
c.2543_2544CC>TT; p.S848F; 2:101869701-101869702	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3643C>A; p.L1215M; 2:101887841-101887841	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.222G>T; p.K74N; 2:101823969-101823969	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1430G>C; p.R477P; 2:101859030-101859030	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3553G>A; p.V1185I; 2:101887211-101887211	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.754C>T; p.R252W; 2:101835959-101835959	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2639+1G>A; p.?; 2:101869798-101869798	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.65C>T; p.A22V; 2:101698480-101698480	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1731C>A; p.N577K; 2:101860851-101860851	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1731C>A; p.N577K; 2:101860851-101860851	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.922C>T; p.R308C; 2:101839967-101839967	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.639+1G>A; p.?; 2:101831852-101831852	skin	malignant_melanoma	Unknown
c.639+1G>A; p.?; 2:101831852-101831852	skin	malignant_melanoma	Unknown
c.1245A>G; p.R415R; 2:101855988-101855988	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.942C>T; p.G314G; 2:101839987-101839987	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3160C>T; p.L1054F; 2:101877113-101877113	urinary_tract; bladder	carcinoma	Substitution - Missense
c.821A>G; p.Y274C; 2:101839866-101839866	liver	carcinoma	Substitution - Missense
c.821A>G; p.Y274C; 2:101839866-101839866	liver	carcinoma	Substitution - Missense
c.756_757insCT; p.K254fs*1; 2:101835961-101835962	endometrium	carcinoma; endometrioid_carcinoma	Insertion - Frameshift
c.2250G>T; p.V750V; 2:101866473-101866473	breast	carcinoma	Substitution - coding silent
c.1614G>A; p.Q538Q; 2:101859774-101859774	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3905G>A; p.G1302D; 2:101891191-101891191	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1193G>A; p.R398Q; 2:101844271-101844271	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1320G>T; p.E440D; 2:101856063-101856063	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.441T>C; p.H147H; 2:101829527-101829527	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2307G>T; p.G769G; 2:101866530-101866530	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.71T>G; p.I24S; 2:101698486-101698486	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.343G>A; p.D115N; 2:101825355-101825355	skin	malignant_melanoma	Substitution - Missense
c.2548G>A; p.E850K; 2:101869706-101869706	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.418G>T; p.G140*; 2:101829504-101829504	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2334C>T; p.S778S; 2:101866557-101866557	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.527C>A; p.A176D; 2:101831739-101831739	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1552C>T; p.Q518*; 2:101859712-101859712	oesophagus	carcinoma	Substitution - Nonsense
c.1703A>T; p.E568V; 2:101859863-101859863	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1637G>T; p.R546M; 2:101859797-101859797	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3838A>G; p.R1280G; 2:101888894-101888894	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3838A>G; p.R1280G; 2:101888894-101888894	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.971G>T; p.S324I; 2:101842630-101842630	skin	malignant_melanoma	Substitution - Missense
c.748C>T; p.P250S; 2:101835953-101835953	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1145G>A; p.R382Q; 2:101844223-101844223	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.451C>T; p.H151Y; 2:101829537-101829537	breast	carcinoma	Substitution - Missense
c.2528C>T; p.T843M; 2:101869686-101869686	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2561C>T; p.T854M; 2:101869719-101869719	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2958T>A; p.N986K; 2:101874161-101874161	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.92T>G; p.V31G; 2:101698507-101698507	skin	malignant_melanoma	Substitution - Missense
c.2072_2075delCAGA; p.D692fs*10; 2:101864026-101864029	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Deletion - Frameshift
c.3809G>A; p.G1270D; 2:101888865-101888865	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3809G>A; p.G1270D; 2:101888865-101888865	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1358G>A; p.R453Q; 2:101856101-101856101	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1919G>A; p.R640Q; 2:101863873-101863873	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2072C>T; p.S691L; 2:101864026-101864026	skin	malignant_melanoma	Substitution - Missense
c.943G>A; p.E315K; 2:101839988-101839988	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2072C>T; p.S691L; 2:101864026-101864026	skin	malignant_melanoma	Substitution - Missense
c.3296G>T; p.G1099V; 2:101882653-101882653	kidney	other; neoplasm	Substitution - Missense
c.3604G>A; p.A1202T; 2:101887802-101887802	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3666G>A; p.G1222G; 2:101887864-101887864	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1430G>A; p.R477Q; 2:101859030-101859030	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1430G>A; p.R477Q; 2:101859030-101859030	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.3298G>A; p.D1100N; 2:101882655-101882655	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2942C>T; p.S981L; 2:101874145-101874145	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2473G>A; p.A825T; 2:101869631-101869631	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.391G>A; p.A131T; 2:101825403-101825403	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1222_1223insGGCTAGAA; p.E411fs*2; 2:101844300-101844301	endometrium	carcinoma; endometrioid_carcinoma	Insertion - Frameshift
c.833C>T; p.P278L; 2:101839878-101839878	skin	malignant_melanoma	Substitution - Missense
c.833C>T; p.P278L; 2:101839878-101839878	skin	malignant_melanoma	Substitution - Missense
c.3856T>C; p.F1286L; 2:101888912-101888912	breast	carcinoma	Substitution - Missense
c.3129C>A; p.I1043I; 2:101877082-101877082	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1197T>A; p.I399I; 2:101844275-101844275	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.717G>A; p.M239I; 2:101835922-101835922	ovary	other; neoplasm	Substitution - Missense
c.1060C>A; p.R354R; 2:101844138-101844138	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.933G>A; p.K311K; 2:101839978-101839978	breast	carcinoma	Substitution - coding silent
c.1059C>T; p.R353R; 2:101844137-101844137	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2669C>T; p.T890M; 2:101870324-101870324	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2186G>T; p.G729V; 2:101865018-101865018	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3375T>G; p.S1125S; 2:101885233-101885233	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3341G>T; p.R1114I; 2:101885199-101885199	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3211C>T; p.R1071C; 2:101882568-101882568	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1273C>T; p.R425C; 2:101856016-101856016	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]