Entrez Gene

Basic Information
Gene ID	8338
Name	HIST2H2AC
Synonymous	histone cluster 2, H2ac;HIST2H2AC;histone cluster 2, H2ac
Definition	H2A histone family, member Q\|histone 2, H2ac\|histone H2A type 2-C\|histone H2A-GL101\|histone H2A/q\|histone IIa
Position	1q21.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.363C>G; p.T121T; 1:149887337-149887337	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.132G>C; p.V44V; 1:149887106-149887106	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.132G>C; p.V44V; 1:149887106-149887106	NS	malignant_melanoma	Substitution - coding silent
c.132G>C; p.V44V; 1:149887106-149887106	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.305C>G; p.T102S; 1:149887279-149887279	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.186G>T; p.E62D; 1:149887160-149887160	urinary_tract; bladder	carcinoma	Substitution - Missense
c.215G>T; p.R72L; 1:149887189-149887189	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.35G>T; p.R12L; 1:149887009-149887009	urinary_tract; bladder	carcinoma	Substitution - Missense
c.252C>G; p.L84L; 1:149887226-149887226	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.252C>G; p.L84L; 1:149887226-149887226	breast	carcinoma	Substitution - coding silent
c.279_280insC; p.L94fs*18; 1:149887253-149887254	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.274G>C; p.E92Q; 1:149887248-149887248	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.274G>C; p.E92Q; 1:149887248-149887248	urinary_tract; bladder	carcinoma	Substitution - Missense
c.244C>T; p.R82C; 1:149887218-149887218	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.106C>T; p.R36C; 1:149887080-149887080	stomach	adenocarcinoma	Substitution - Missense
c.186G>A; p.E62E; 1:149887160-149887160	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.154A>C; p.M52L; 1:149887128-149887128	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.186G>A; p.E62E; 1:149887160-149887160	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.290T>C; p.L97P; 1:149887264-149887264	skin; shoulder	malignant_melanoma	Substitution - Missense
c.357G>C; p.K119N; 1:149887331-149887331	prostate	adenoma	Substitution - Missense
c.357G>C; p.K119N; 1:149887331-149887331	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.303C>T; p.V101V; 1:149887277-149887277	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.274G>A; p.E92K; 1:149887248-149887248	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.330T>C; p.P110P; 1:149887304-149887304	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.330T>C; p.P110P; 1:149887304-149887304	NS	malignant_melanoma	Substitution - coding silent
c.309C>A; p.I103I; 1:149887283-149887283	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.279A>G; p.E93E; 1:149887253-149887253	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.279A>G; p.E93E; 1:149887253-149887253	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.369C>T; p.S123S; 1:149887343-149887343	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.389A>C; p.*130S; 1:149887363-149887363	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Nonstop extension
c.183C>G; p.A61A; 1:149887157-149887157	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.183C>G; p.A61A; 1:149887157-149887157	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.282G>C; p.L94L; 1:149887256-149887256	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.287A>T; p.K96M; 1:149887261-149887261	breast	carcinoma	Substitution - Missense
c.332A>G; p.N111S; 1:149887306-149887306	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.74A>G; p.Q25R; 1:149887048-149887048	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.74A>G; p.Q25R; 1:149887048-149887048	large_intestine; rectum	NS	Substitution - Missense
c.74A>G; p.Q25R; 1:149887048-149887048	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.378_379insTGGCAAGA; p.K127fs*>6; 1:149887352-149887353	meninges	meningioma	Insertion - Frameshift
c.382A>G; p.S128G; 1:149887356-149887356	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.315G>C; p.Q105H; 1:149887289-149887289	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.84A>G; p.V28V; 1:149887058-149887058	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.84A>G; p.V28V; 1:149887058-149887058	NS	malignant_melanoma	Substitution - coding silent
c.84A>G; p.V28V; 1:149887058-149887058	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.58T>C; p.S20P; 1:149887032-149887032	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.342C>G; p.A114A; 1:149887316-149887316	breast	carcinoma	Substitution - coding silent
c.329C>T; p.P110L; 1:149887303-149887303	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.39C>T; p.A13A; 1:149887013-149887013	NS	malignant_melanoma	Substitution - coding silent
c.39C>T; p.A13A; 1:149887013-149887013	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.39C>T; p.A13A; 1:149887013-149887013	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.362C>A; p.T121N; 1:149887336-149887336	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.291G>A; p.L97L; 1:149887265-149887265	breast	carcinoma	Substitution - coding silent
c.69C>T; p.G23G; 1:149887043-149887043	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.69C>T; p.G23G; 1:149887043-149887043	NS	malignant_melanoma	Substitution - coding silent
c.69C>T; p.G23G; 1:149887043-149887043	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.69C>T; p.G23G; 1:149887043-149887043	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.277G>C; p.E93Q; 1:149887251-149887251	ovary	other; neoplasm	Substitution - Missense
c.277G>C; p.E93Q; 1:149887251-149887251	ovary	other; neoplasm	Substitution - Missense
c.56C>A; p.S19*; 1:149887030-149887030	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.138C>A; p.A46A; 1:149887112-149887112	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.138C>A; p.A46A; 1:149887112-149887112	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.159G>A; p.A53A; 1:149887133-149887133	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.72C>A; p.L24L; 1:149887046-149887046	breast	carcinoma	Substitution - coding silent
c.271G>T; p.D91Y; 1:149887245-149887245	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.123G>A; p.A41A; 1:149887097-149887097	pancreas	carcinoma	Substitution - coding silent
c.373A>G; p.K125E; 1:149887347-149887347	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.373A>G; p.K125E; 1:149887347-149887347	pancreas	carcinoma	Substitution - Missense
c.45C>T; p.A15A; 1:149887019-149887019	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.45C>T; p.A15A; 1:149887019-149887019	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.309C>T; p.I103I; 1:149887283-149887283	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.73C>T; p.Q25*; 1:149887047-149887047	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.73C>T; p.Q25*; 1:149887047-149887047	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.14G>A; p.G5D; 1:149886988-149886988	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.14G>A; p.G5D; 1:149886988-149886988	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.266G>C; p.R89P; 1:149887240-149887240	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.152A>G; p.Y51C; 1:149887126-149887126	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.173A>G; p.Y58C; 1:149887147-149887147	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.271G>C; p.D91H; 1:149887245-149887245	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.169G>C; p.E57Q; 1:149887143-149887143	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.362C>T; p.T121I; 1:149887336-149887336	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.225G>C; p.K75N; 1:149887199-149887199	breast	carcinoma	Substitution - Missense
c.249C>T; p.H83H; 1:149887223-149887223	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.189C>T; p.I63I; 1:149887163-149887163	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.189C>T; p.I63I; 1:149887163-149887163	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.282G>A; p.L94L; 1:149887256-149887256	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.282G>A; p.L94L; 1:149887256-149887256	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.282G>A; p.L94L; 1:149887256-149887256	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.282G>A; p.L94L; 1:149887256-149887256	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.345_346delTC; p.L116fs*>14; 1:149887319-149887320	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.168C>G; p.L56L; 1:149887142-149887142	NS	NS	Substitution - coding silent
c.313C>G; p.Q105E; 1:149887287-149887287	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.36C>T; p.R12R; 1:149887010-149887010	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.229A>G; p.T77A; 1:149887203-149887203	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.30G>A; p.K10K; 1:149887004-149887004	breast	carcinoma	Substitution - coding silent
c.355A>G; p.K119E; 1:149887329-149887329	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.355A>G; p.K119E; 1:149887329-149887329	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.177G>C; p.L59L; 1:149887151-149887151	lung	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]