Entrez Gene

Basic Information
Gene ID	7042
Name	TGFB2
Synonymous	transforming growth factor, beta 2;TGFB2;transforming growth factor, beta 2
Definition	BSC-1 cell growth inhibitor\|G-TSF\|cetermin\|glioblastoma-derived T-cell suppressor factor\|polyergin\|prepro-transforming growth factor beta-2\|transforming growth factor beta-2
Position	1q41
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1203A>G; p.E401E; 1:218441320-218441320	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1171C>G; p.L391V; 1:218441288-218441288	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.356C>T; p.P119L; 1:218405178-218405178	skin	malignant_melanoma	Substitution - Missense
c.414G>A; p.E138E; 1:218405236-218405236	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.392G>A; p.R131Q; 1:218405214-218405214	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.32T>C; p.I11T; 1:218346733-218346733	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.392G>A; p.R131Q; 1:218405214-218405214	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.695T>A; p.V232E; 1:218434389-218434389	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.893delG; p.R299fs*32; 1:218436108-218436108	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.458G>A; p.R153H; 1:218405280-218405280	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.514C>A; p.L172I; 1:218434085-218434085	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.755-7T>C; p.?; 1:218435963-218435963	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.755-7T>C; p.?; 1:218435963-218435963	liver	carcinoma	Unknown
c.1140C>T; p.C380C; 1:218441257-218441257	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1140C>T; p.C380C; 1:218441257-218441257	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.551A>G; p.Y184C; 1:218434122-218434122	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.755-8T>G; p.?; 1:218435962-218435962	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.242A>G; p.K81R; 1:218346943-218346943	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.647G>T; p.R216M; 1:218434341-218434341	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1043G>A; p.G348E; 1:218437453-218437453	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.968A>G; p.Y323C; 1:218437378-218437378	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.617C>A; p.A206D; 1:218434188-218434188	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.224G>T; p.R75M; 1:218346925-218346925	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1135T>A; p.C379S; 1:218441252-218441252	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.189delC; p.P65fs*3; 1:218346890-218346890	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.530T>G; p.L177*; 1:218434101-218434101	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.806C>T; p.S269F; 1:218436021-218436021	skin	malignant_melanoma	Substitution - Missense
c.81C>T; p.L27L; 1:218346782-218346782	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.806C>T; p.S269F; 1:218436021-218436021	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.453C>A; p.V151V; 1:218405275-218405275	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.124G>A; p.G42R; 1:218346825-218346825	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.457C>T; p.R153C; 1:218405279-218405279	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.457C>T; p.R153C; 1:218405279-218405279	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.322A>G; p.M108V; 1:218347023-218347023	urinary_tract; bladder	carcinoma	Substitution - Missense
c.322A>G; p.M108V; 1:218347023-218347023	urinary_tract; bladder	carcinoma	Substitution - Missense
c.457C>T; p.R153C; 1:218405279-218405279	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.614A>T; p.D205V; 1:218434185-218434185	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1053G>C; p.P351P; 1:218437463-218437463	thyroid	carcinoma	Substitution - coding silent
c.210C>T; p.I70I; 1:218346911-218346911	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.488A>T; p.E163V; 1:218405310-218405310	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.400G>A; p.V134I; 1:218405222-218405222	breast	carcinoma	Substitution - Missense
c.120C>T; p.I40I; 1:218346821-218346821	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.120C>T; p.I40I; 1:218346821-218346821	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.919G>A; p.A307T; 1:218436134-218436134	skin; acral	malignant_melanoma	Substitution - Missense
c.919G>A; p.A307T; 1:218436134-218436134	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.864C>A; p.S288S; 1:218436079-218436079	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.556G>A; p.D186N; 1:218434127-218434127	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.896G>T; p.R299L; 1:218436111-218436111	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.556G>A; p.D186N; 1:218434127-218434127	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.814delA; p.N274fs*10; 1:218436029-218436029	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.814delA; p.N274fs*10; 1:218436029-218436029	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.814delA; p.N274fs*10; 1:218436029-218436029	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.615T>G; p.D205E; 1:218434186-218434186	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.760G>A; p.D254N; 1:218435975-218435975	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.924T>C; p.Y308Y; 1:218436139-218436139	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.343G>A; p.E115K; 1:218347044-218347044	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.813_814insA; p.N274fs*19; 1:218436028-218436029	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.555C>T; p.I185I; 1:218434126-218434126	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.144G>A; p.L48L; 1:218346845-218346845	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1098A>T; p.L366F; 1:218441215-218441215	liver	carcinoma	Substitution - Missense
c.1216A>G; p.M406V; 1:218441333-218441333	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1098A>T; p.L366F; 1:218441215-218441215	liver	carcinoma	Substitution - Missense
c.826delG; p.K277fs*7; 1:218436041-218436041	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1146C>T; p.S382S; 1:218441263-218441263	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.729T>C; p.S243S; 1:218434423-218434423	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.588C>T; p.G196G; 1:218434159-218434159	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.195G>A; p.P65P; 1:218346896-218346896	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.142C>T; p.L48L; 1:218346843-218346843	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.391C>T; p.R131*; 1:218405213-218405213	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.391C>T; p.R131*; 1:218405213-218405213	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.726A>C; p.K242N; 1:218434420-218434420	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.604G>A; p.D202N; 1:218434175-218434175	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.447C>A; p.F149L; 1:218405269-218405269	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.23_24insT; p.L10fs*50; 1:218346724-218346725	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.541A>G; p.T181A; 1:218434112-218434112	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.541A>G; p.T181A; 1:218434112-218434112	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.117G>A; p.A39A; 1:218346818-218346818	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.953G>A; p.C318Y; 1:218437363-218437363	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1150G>A; p.D384N; 1:218441267-218441267	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.174T>G; p.P58P; 1:218346875-218346875	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.111C>T; p.I37I; 1:218346812-218346812	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.268G>A; p.E90K; 1:218346969-218346969	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.518A>C; p.K173T; 1:218434089-218434089	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.679C>T; p.P227S; 1:218434373-218434373	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.679C>T; p.P227S; 1:218434373-218434373	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1141G>A; p.V381M; 1:218441258-218441258	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.570G>C; p.V190V; 1:218434141-218434141	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.984G>T; p.R328S; 1:218437394-218437394	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.529T>G; p.L177V; 1:218434100-218434100	breast	carcinoma	Substitution - Missense
c.1217T>C; p.M406T; 1:218441334-218441334	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.623A>G; p.H208R; 1:218434194-218434194	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.817A>G; p.K273E; 1:218436032-218436032	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1201G>C; p.E401Q; 1:218441318-218441318	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1174T>C; p.Y392H; 1:218441291-218441291	liver	carcinoma	Substitution - Missense
c.1174T>C; p.Y392H; 1:218441291-218441291	liver	carcinoma	Substitution - Missense
c.1066T>G; p.S356A; 1:218437476-218437476	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]