Entrez Gene

Basic Information
Gene ID	6772
Name	STAT1
Synonymous	signal transducer and activator of transcription 1, 91kDa;STAT1;signal transducer and activator of transcription 1, 91kDa
Definition	signal transducer and activator of transcription 1, 91kD\|signal transducer and activator of transcription 1-alpha/beta\|signal transducer and activator of transcription-1\|transcription factor ISGF-3 components p91/p84
Position	2q32.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.995C>T; p.P332L; 2:190991270-190991270	liver	carcinoma	Substitution - Missense
c.995C>T; p.P332L; 2:190991270-190991270	liver	carcinoma	Substitution - Missense
c.1191T>C; p.N397N; 2:190986884-190986884	liver	carcinoma	Substitution - coding silent
c.1191T>C; p.N397N; 2:190986884-190986884	liver	carcinoma	Substitution - coding silent
c.649A>C; p.I217L; 2:190997992-190997992	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1450C>T; p.L484L; 2:190982515-190982515	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1086C>A; p.V362V; 2:190989626-190989626	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1912G>A; p.E638K; 2:190976987-190976987	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2085C>T; p.G695G; 2:190975862-190975862	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2131G>A; p.E711K; 2:190975816-190975816	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2131G>A; p.E711K; 2:190975816-190975816	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.355G>A; p.A119T; 2:191007580-191007580	pancreas	carcinoma	Substitution - Missense
c.1344C>A; p.L448L; 2:190984313-190984313	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.199C>T; p.Q67*; 2:191009037-191009037	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1276G>A; p.V426I; 2:190984381-190984381	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1946G>A; p.R649H; 2:190976953-190976953	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1725T>A; p.D575E; 2:190979774-190979774	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1380C>T; p.N460N; 2:190983708-190983708	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1214G>A; p.R405Q; 2:190986861-190986861	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1701delA; p.K567fs*25; 2:190979798-190979798	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1874-1G>C; p.?; 2:190977026-190977026	urinary_tract; bladder	carcinoma	Unknown
c.2229C>T; p.F743F; 2:190974839-190974839	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1256C>T; p.T419M; 2:190985626-190985626	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.261G>T; p.K87N; 2:191008975-191008975	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.85G>C; p.E29Q; 2:191009919-191009919	skin	malignant_melanoma	Substitution - Missense
c.1657C>T; p.P553S; 2:190979842-190979842	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1778A>T; p.D593V; 2:190978951-190978951	breast	carcinoma	Substitution - Missense
c.1600G>A; p.D534N; 2:190980652-190980652	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1692C>T; p.L564L; 2:190979807-190979807	skin	malignant_melanoma	Substitution - coding silent
c.485G>T; p.S162I; 2:190999682-190999682	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.838T>A; p.L280M; 2:190995167-190995167	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.500A>G; p.Q167R; 2:190999667-190999667	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1822C>T; p.R608W; 2:190978907-190978907	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1166T>G; p.V389G; 2:190986909-190986909	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.623A>G; p.N208S; 2:190998227-190998227	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.389T>C; p.I130T; 2:191001147-191001147	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.867C>T; p.Y289Y; 2:190995138-190995138	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1452G>A; p.L484L; 2:190982513-190982513	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.1531A>G; p.K511E; 2:190982434-190982434	urinary_tract; bladder	carcinoma	Substitution - Missense
c.836delA; p.K279fs*57; 2:190995169-190995169	oesophagus; lower_third	carcinoma; adenocarcinoma	Deletion - Frameshift
c.16G>A; p.E6K; 2:191009988-191009988	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.116A>T; p.E39V; 2:191009888-191009888	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.890_891insA; p.N297fs*61; 2:190995114-190995115	oesophagus; lower_third	carcinoma; adenocarcinoma	Insertion - Frameshift
c.502G>C; p.D168H; 2:190999665-190999665	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1735A>C; p.M579L; 2:190978994-190978994	skin	malignant_melanoma	Substitution - Missense
c.1787C>T; p.P596L; 2:190978942-190978942	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.231C>A; p.F77L; 2:191009005-191009005	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.586C>T; p.Q196*; 2:190998264-190998264	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.892A>C; p.K298Q; 2:190995113-190995113	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1584T>C; p.G528G; 2:190980668-190980668	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - coding silent
c.1265G>C; p.G422A; 2:190984392-190984392	pleura	pulmonary_blastoma	Substitution - Missense
c.1945C>T; p.R649C; 2:190976954-190976954	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1945C>T; p.R649C; 2:190976954-190976954	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1945C>T; p.R649C; 2:190976954-190976954	skin; mucosal	malignant_melanoma	Substitution - Missense
c.602A>G; p.K201R; 2:190998248-190998248	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2197G>T; p.E733*; 2:190974871-190974871	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Nonsense
c.1087T>G; p.L363V; 2:190989625-190989625	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1985A>T; p.N662I; 2:190976914-190976914	liver	carcinoma	Substitution - Missense
c.1985A>T; p.N662I; 2:190976914-190976914	liver	carcinoma	Substitution - Missense
c.1471C>G; p.P491A; 2:190982494-190982494	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1471C>G; p.P491A; 2:190982494-190982494	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1203G>A; p.A401A; 2:190986872-190986872	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2042A>T; p.Y681F; 2:190976857-190976857	lung	carcinoma; undifferentiated_carcinoma	Substitution - Missense
c.981G>T; p.T327T; 2:190991284-190991284	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1591G>A; p.A531T; 2:190980661-190980661	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2090A>T; p.K697I; 2:190975857-190975857	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.362G>T; p.R121I; 2:191007573-191007573	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1997A>G; p.Y666C; 2:190976902-190976902	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1473A>G; p.P491P; 2:190982492-190982492	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1473A>G; p.P491P; 2:190982492-190982492	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1651A>C; p.N551H; 2:190979848-190979848	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.215C>A; p.S72Y; 2:191009021-191009021	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.881T>C; p.I294T; 2:190995124-190995124	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.494A>C; p.D165A; 2:190999673-190999673	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.567G>C; p.K189N; 2:190998283-190998283	breast	carcinoma	Substitution - Missense
c.1633-1G>C; p.?; 2:190979867-190979867	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1915C>A; p.L639I; 2:190976984-190976984	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.167G>A; p.R56H; 2:191009069-191009069	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.381G>C; p.S127S; 2:191001155-191001155	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.735C>T; p.S245S; 2:190997906-190997906	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.79C>T; p.P27S; 2:191009925-191009925	skin	malignant_melanoma	Substitution - Missense
c.602A>T; p.K201M; 2:190998248-190998248	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.602A>T; p.K201M; 2:190998248-190998248	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1890G>A; p.A630A; 2:190977009-190977009	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.551C>T; p.T184I; 2:190998299-190998299	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1098A>T; p.K366N; 2:190987068-190987068	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1118C>A; p.T373K; 2:190987048-190987048	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1496C>T; p.S499L; 2:190982469-190982469	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.262C>T; p.R88C; 2:191008974-191008974	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1496C>T; p.S499L; 2:190982469-190982469	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1428G>T; p.M476I; 2:190983660-190983660	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1703A>C; p.H568P; 2:190979796-190979796	breast	carcinoma	Substitution - Missense
c.2012T>C; p.I671T; 2:190976887-190976887	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.800C>T; p.A267V; 2:190995205-190995205	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1730G>A; p.C577Y; 2:190978999-190978999	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.725G>C; p.R242T; 2:190997916-190997916	thyroid	carcinoma	Substitution - Missense
c.1825G>A; p.E609K; 2:190978904-190978904	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1257G>A; p.T419T; 2:190985625-190985625	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.681C>A; p.T227T; 2:190997960-190997960	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1613C>T; p.P538L; 2:190980639-190980639	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1600G>T; p.D534Y; 2:190980652-190980652	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.821G>A; p.R274Q; 2:190995184-190995184	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1687G>A; p.E563K; 2:190979812-190979812	liver	carcinoma	Substitution - Missense
c.1687G>A; p.E563K; 2:190979812-190979812	liver	carcinoma	Substitution - Missense
c.1687G>A; p.E563K; 2:190979812-190979812	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecified	Substitution - Missense
c.1387C>G; p.Q463E; 2:190983701-190983701	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.557G>T; p.G186V; 2:190998293-190998293	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.722G>A; p.R241Q; 2:190997919-190997919	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1665G>C; p.W555C; 2:190979834-190979834	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1924G>A; p.V642I; 2:190976975-190976975	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1728-1G>T; p.?; 2:190979002-190979002	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1227G>T; p.L409F; 2:190985655-190985655	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1612C>T; p.P538S; 2:190980640-190980640	skin	malignant_melanoma	Substitution - Missense
c.1227G>T; p.L409F; 2:190985655-190985655	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1912G>T; p.E638*; 2:190976987-190976987	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.460A>T; p.M154L; 2:191001076-191001076	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1912G>T; p.E638*; 2:190976987-190976987	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1128-2A>C; p.?; 2:190986949-190986949	stomach	carcinoma; adenocarcinoma	Unknown
c.1236G>C; p.Q412H; 2:190985646-190985646	breast	carcinoma	Substitution - Missense
c.601A>G; p.K201E; 2:190998249-190998249	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.280T>G; p.F94V; 2:191007655-191007655	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.505G>A; p.E169K; 2:190999662-190999662	liver	carcinoma	Substitution - Missense
c.505G>A; p.E169K; 2:190999662-190999662	liver	carcinoma	Substitution - Missense
c.721C>T; p.R241W; 2:190997920-190997920	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.371A>G; p.Q124R; 2:191007564-191007564	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1492C>G; p.L498V; 2:190982473-190982473	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.721C>T; p.R241W; 2:190997920-190997920	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1889C>T; p.A630V; 2:190977010-190977010	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1889C>T; p.A630V; 2:190977010-190977010	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1889C>T; p.A630V; 2:190977010-190977010	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1889C>T; p.A630V; 2:190977010-190977010	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.46_47insGCCTGG; p.L15_E16insGL; 2:191009957-191009958	breast	carcinoma	Insertion - In frame
c.2135T>C; p.V712A; 2:190975812-190975812	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1405G>A; p.A469T; 2:190983683-190983683	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1823G>A; p.R608Q; 2:190978906-190978906	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1504C>T; p.L502L; 2:190982461-190982461	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1221+2T>C; p.?; 2:190986852-190986852	stomach	carcinoma; adenocarcinoma	Unknown
c.1195A>G; p.S399G; 2:190986880-190986880	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2194G>C; p.D732H; 2:190974874-190974874	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1472C>A; p.P491Q; 2:190982493-190982493	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1436C>T; p.A479V; 2:190983652-190983652	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2113G>A; p.E705K; 2:190975834-190975834	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1184C>T; p.S395F; 2:190986891-190986891	skin	malignant_melanoma	Substitution - Missense
c.2136-10C>T; p.?; 2:190974942-190974942	liver	carcinoma	Unknown
c.2113G>A; p.E705K; 2:190975834-190975834	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2113G>A; p.E705K; 2:190975834-190975834	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1650A>C; p.K550N; 2:190979849-190979849	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1650A>C; p.K550N; 2:190979849-190979849	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1633-3C>A; p.?; 2:190979869-190979869	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Unknown
c.171T>A; p.F57L; 2:191009065-191009065	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1429C>T; p.L477L; 2:190983659-190983659	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.920G>A; p.S307N; 2:190995085-190995085	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1270C>G; p.L424V; 2:190984387-190984387	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1062G>A; p.L354L; 2:190989650-190989650	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.597C>G; p.L199L; 2:190998253-190998253	breast	carcinoma	Substitution - coding silent
c.595C>G; p.L199V; 2:190998255-190998255	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1445G>T; p.R482M; 2:190983643-190983643	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.312C>T; p.I104I; 2:191007623-191007623	skin	malignant_melanoma	Substitution - coding silent
c.942G>A; p.Q314Q; 2:190995063-190995063	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.539G>C; p.R180T; 2:190999628-190999628	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2154G>C; p.Q718H; 2:190974914-190974914	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2154G>C; p.Q718H; 2:190974914-190974914	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Missense
c.372+3A>G; p.?; 2:191007560-191007560	liver	carcinoma	Unknown
c.1874-8C>T; p.?; 2:190977033-190977033	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1874-8C>T; p.?; 2:190977033-190977033	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.820C>T; p.R274W; 2:190995185-190995185	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1540C>G; p.L514V; 2:190982425-190982425	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2200G>C; p.V734L; 2:190974868-190974868	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.988C>A; p.Q330K; 2:190991277-190991277	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.988C>A; p.Q330K; 2:190991277-190991277	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]