Entrez Gene

Basic Information
Gene ID	64849
Name	SLC13A3
Synonymous	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3;SLC13A3;solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Definition	Na(+)/dicarboxylate cotransporter 3\|hNaDC3\|naDC-3\|sodium-dependent high affinity dicarboxylate transporter 3\|sodium-dependent high-affinity dicarboxylate transporter 2\|solute carrier family 13 member 3
Position	20q13.12
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1799G>A; p.R600Q; 20:46560032-46560032	pancreas	carcinoma	Substitution - Missense
c.1480G>T; p.V494F; 20:46566243-46566243	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1741G>A; p.D581N; 20:46560090-46560090	breast	carcinoma	Substitution - Missense
c.1480G>T; p.V494F; 20:46566243-46566243	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1496C>T; p.A499V; 20:46563550-46563550	skin	malignant_melanoma	Substitution - Missense
c.986G>A; p.R329Q; 20:46589190-46589190	central_nervous_system; brain	glioma	Substitution - Missense
c.529G>A; p.E177K; 20:46610458-46610458	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.559G>A; p.G187S; 20:46600020-46600020	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1317G>T; p.M439I; 20:46575588-46575588	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.212C>T; p.P71L; 20:46613625-46613625	skin	malignant_melanoma	Substitution - Missense
c.1387C>T; p.P463S; 20:46566336-46566336	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1229C>G; p.T410R; 20:46575676-46575676	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.997C>T; p.Q333*; 20:46589179-46589179	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1752G>A; p.S584S; 20:46560079-46560079	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1752G>A; p.S584S; 20:46560079-46560079	skin	malignant_melanoma	Substitution - coding silent
c.1330G>C; p.E444Q; 20:46575575-46575575	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1597G>A; p.A533T; 20:46563449-46563449	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.690C>G; p.I230M; 20:46596261-46596261	ovary	other; neoplasm	Substitution - Missense
c.188C>T; p.A63V; 20:46613649-46613649	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1482C>T; p.V494V; 20:46566241-46566241	skin	malignant_melanoma	Substitution - coding silent
c.188C>T; p.A63V; 20:46613649-46613649	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1337C>T; p.S446L; 20:46566386-46566386	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1337C>T; p.S446L; 20:46566386-46566386	skin	malignant_melanoma	Substitution - Missense
c.1494+3G>A; p.?; 20:46566226-46566226	parathyroid	carcinoma	Unknown
c.844G>A; p.A282T; 20:46592480-46592480	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1587delC; p.N530fs*21; 20:46563459-46563459	liver	carcinoma	Deletion - Frameshift
c.1342C>T; p.L448L; 20:46566381-46566381	skin	malignant_melanoma	Substitution - coding silent
c.973C>T; p.R325*; 20:46589203-46589203	skin	malignant_melanoma	Substitution - Nonsense
c.625G>A; p.E209K; 20:46596326-46596326	skin	malignant_melanoma	Substitution - Missense
c.474C>T; p.I158I; 20:46610513-46610513	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1530G>A; p.M510I; 20:46563516-46563516	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.162G>A; p.T54T; 20:46613675-46613675	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.427A>G; p.S143G; 20:46610560-46610560	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.261C>T; p.L87L; 20:46613576-46613576	liver	carcinoma	Substitution - coding silent
c.1501C>T; p.R501C; 20:46563545-46563545	skin	malignant_melanoma	Substitution - Missense
c.1318G>A; p.A440T; 20:46575587-46575587	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1318G>A; p.A440T; 20:46575587-46575587	skin	malignant_melanoma	Substitution - Missense
c.261C>T; p.L87L; 20:46613576-46613576	liver	carcinoma	Substitution - coding silent
c.1501C>T; p.R501C; 20:46563545-46563545	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1568T>A; p.L523H; 20:46563478-46563478	pancreas	carcinoma	Substitution - Missense
c.1637G>A; p.R546Q; 20:46560194-46560194	prostate	adenoma	Substitution - Missense
c.1392delC; p.A465fs*38; 20:46566331-46566331	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1392delC; p.A465fs*38; 20:46566331-46566331	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1392delC; p.A465fs*38; 20:46566331-46566331	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.457C>T; p.P153S; 20:46610530-46610530	skin	malignant_melanoma	Substitution - Missense
c.421T>C; p.W141R; 20:46610566-46610566	breast	carcinoma	Substitution - Missense
c.1581G>A; p.T527T; 20:46563465-46563465	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1491G>A; p.E497E; 20:46566232-46566232	skin	malignant_melanoma	Substitution - coding silent
c.323T>C; p.L108P; 20:46613514-46613514	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.843C>T; p.F281F; 20:46592481-46592481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.843C>T; p.F281F; 20:46592481-46592481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1219+2T>C; p.?; 20:46583570-46583570	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.737G>A; p.G246D; 20:46596214-46596214	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.737G>A; p.G246D; 20:46596214-46596214	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.526A>C; p.S176R; 20:46610461-46610461	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1603G>A; p.A535T; 20:46563443-46563443	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1157T>C; p.V386A; 20:46583634-46583634	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1603G>A; p.A535T; 20:46563443-46563443	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.332G>A; p.R111Q; 20:46613505-46613505	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.332G>A; p.R111Q; 20:46613505-46613505	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.710C>T; p.S237F; 20:46596241-46596241	skin	malignant_melanoma	Substitution - Missense
c.498G>T; p.K166N; 20:46610489-46610489	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1462A>G; p.I488V; 20:46566261-46566261	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.145G>T; p.A49S; 20:46613692-46613692	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.802C>T; p.P268S; 20:46592522-46592522	skin	malignant_melanoma	Substitution - Missense
c.1011C>T; p.P337P; 20:46589165-46589165	skin	malignant_melanoma	Substitution - coding silent
c.198C>T; p.P66P; 20:46613639-46613639	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1016+1G>A; p.?; 20:46589159-46589159	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1757A>G; p.N586S; 20:46560074-46560074	breast	carcinoma	Substitution - Missense
c.506G>A; p.R169Q; 20:46610481-46610481	breast	carcinoma	Substitution - Missense
c.1173C>T; p.F391F; 20:46583618-46583618	breast	carcinoma	Substitution - coding silent
c.506G>A; p.R169Q; 20:46610481-46610481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.947T>C; p.I316T; 20:46589229-46589229	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.471C>T; p.A157A; 20:46610516-46610516	skin	malignant_melanoma	Substitution - coding silent
c.807G>T; p.Q269H; 20:46592517-46592517	liver	carcinoma	Substitution - Missense
c.1672C>A; p.L558M; 20:46560159-46560159	liver	carcinoma	Substitution - Missense
c.807G>T; p.Q269H; 20:46592517-46592517	liver	carcinoma	Substitution - Missense
c.1672C>A; p.L558M; 20:46560159-46560159	liver	carcinoma	Substitution - Missense
c.258C>T; p.F86F; 20:46613579-46613579	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.579G>A; p.T193T; 20:46600000-46600000	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.579G>A; p.T193T; 20:46600000-46600000	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1581G>T; p.T527T; 20:46563465-46563465	oesophagus	carcinoma	Substitution - coding silent
c.1130C>A; p.S377Y; 20:46583661-46583661	breast	carcinoma	Substitution - Missense
c.1146C>T; p.G382G; 20:46583645-46583645	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.550C>G; p.R184G; 20:46600029-46600029	breast	carcinoma	Substitution - Missense
c.1413C>T; p.I471I; 20:46566310-46566310	skin	malignant_melanoma	Substitution - coding silent
c.1413C>T; p.I471I; 20:46566310-46566310	skin	malignant_melanoma	Substitution - coding silent
c.985C>T; p.R329W; 20:46589191-46589191	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1672C>T; p.L558L; 20:46560159-46560159	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1539C>G; p.G513G; 20:46563507-46563507	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1290C>T; p.I430I; 20:46575615-46575615	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1178C>T; p.P393L; 20:46583613-46583613	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1290C>T; p.I430I; 20:46575615-46575615	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1793C>T; p.T598I; 20:46560038-46560038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.512A>T; p.D171V; 20:46610475-46610475	prostate	carcinoma	Substitution - Missense
c.435C>T; p.T145T; 20:46610552-46610552	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.679C>T; p.R227C; 20:46596272-46596272	skin	malignant_melanoma	Substitution - Missense
c.679C>T; p.R227C; 20:46596272-46596272	skin	malignant_melanoma	Substitution - Missense
c.679C>T; p.R227C; 20:46596272-46596272	skin	malignant_melanoma	Substitution - Missense
c.679C>T; p.R227C; 20:46596272-46596272	skin	malignant_melanoma	Substitution - Missense
c.1425C>T; p.I475I; 20:46566298-46566298	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1425C>T; p.I475I; 20:46566298-46566298	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1425C>T; p.I475I; 20:46566298-46566298	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.891C>A; p.I297I; 20:46592433-46592433	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1596C>T; p.I532I; 20:46563450-46563450	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.930G>T; p.R310S; 20:46589246-46589246	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.695A>T; p.K232M; 20:46596256-46596256	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.882G>T; p.W294C; 20:46592442-46592442	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1723A>C; p.T575P; 20:46560108-46560108	breast	carcinoma	Substitution - Missense
c.1278C>T; p.P426P; 20:46575627-46575627	thyroid	other; neoplasm	Substitution - coding silent
c.1580C>T; p.T527M; 20:46563466-46563466	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1580C>T; p.T527M; 20:46563466-46563466	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.379C>A; p.L127I; 20:46610608-46610608	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1276C>T; p.P426S; 20:46575629-46575629	breast	carcinoma	Substitution - Missense
c.158G>A; p.C53Y; 20:46613679-46613679	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.804G>A; p.P268P; 20:46592520-46592520	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1645C>T; p.L549F; 20:46560186-46560186	skin	malignant_melanoma	Substitution - Missense
c.1490A>G; p.E497G; 20:46566233-46566233	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1360G>T; p.G454W; 20:46566363-46566363	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.277T>A; p.F93I; 20:46613560-46613560	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1371C>T; p.H457H; 20:46566352-46566352	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1101G>T; p.W367C; 20:46588079-46588079	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1047C>G; p.F349L; 20:46588133-46588133	urinary_tract; bladder	carcinoma	Substitution - Missense
c.116G>A; p.G39D; 20:46613721-46613721	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1577C>A; p.S526*; 20:46563469-46563469	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1291C>A; p.L431I; 20:46575614-46575614	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.222C>A; p.G74G; 20:46613615-46613615	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1798C>T; p.R600W; 20:46560033-46560033	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1607C>A; p.S536Y; 20:46563439-46563439	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.505C>T; p.R169*; 20:46610482-46610482	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.505C>T; p.R169*; 20:46610482-46610482	skin	malignant_melanoma	Substitution - Nonsense
c.1478C>T; p.P493L; 20:46566245-46566245	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.825C>T; p.F275F; 20:46592499-46592499	skin	malignant_melanoma	Substitution - coding silent
c.825C>T; p.F275F; 20:46592499-46592499	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1525C>A; p.L509M; 20:46563521-46563521	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1525C>A; p.L509M; 20:46563521-46563521	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.304G>A; p.A102T; 20:46613533-46613533	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.826G>T; p.G276C; 20:46592498-46592498	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.436G>A; p.A146T; 20:46610551-46610551	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.304G>A; p.A102T; 20:46613533-46613533	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.682C>T; p.R228W; 20:46596269-46596269	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.888G>C; p.W296C; 20:46592436-46592436	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1042C>A; p.L348I; 20:46588138-46588138	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.518G>T; p.S173I; 20:46610469-46610469	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.331C>T; p.R111*; 20:46613506-46613506	liver	carcinoma	Substitution - Nonsense
c.331C>T; p.R111*; 20:46613506-46613506	liver	carcinoma	Substitution - Nonsense
c.207C>G; p.L69L; 20:46613630-46613630	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.294C>T; p.I98I; 20:46613543-46613543	skin	malignant_melanoma	Substitution - coding silent
c.1149G>T; p.V383V; 20:46583642-46583642	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1741G>T; p.D581Y; 20:46560090-46560090	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1307G>C; p.G436A; 20:46575598-46575598	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.637C>T; p.P213S; 20:46596314-46596314	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1240C>T; p.P414S; 20:46575665-46575665	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1536G>A; p.P512P; 20:46563510-46563510	breast	carcinoma	Substitution - coding silent
c.146C>T; p.A49V; 20:46613691-46613691	skin; extremity	malignant_melanoma	Substitution - Missense
c.390G>A; p.G130G; 20:46610597-46610597	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1047C>T; p.F349F; 20:46588133-46588133	skin	malignant_melanoma	Substitution - coding silent
c.1047C>T; p.F349F; 20:46588133-46588133	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.216C>T; p.F72F; 20:46613621-46613621	breast	carcinoma	Substitution - coding silent
c.216C>T; p.F72F; 20:46613621-46613621	skin	malignant_melanoma	Substitution - coding silent
c.367C>T; p.Q123*; 20:46613470-46613470	skin	malignant_melanoma	Substitution - Nonsense

COSMIC somatic mutation [Top]