| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 6241 |
Name | RRM2 |
Synonymous | ribonucleotide reductase M2;RRM2;ribonucleotide reductase M2 |
Definition | ribonucleoside-diphosphate reductase subunit M2|ribonucleotide reductase M2 polypeptide|ribonucleotide reductase small chain|ribonucleotide reductase small subunit |
Position | 2p25-p24 |
Gene Type | protein-coding |
COSMIC somatic mutation [Top] | |||
Mutation (CDS; AA; Chr) | Site | Histology | Mutation Type |
|---|---|---|---|
c.237C>T; p.R79R; 2:10123449-10123449 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.665-3T>C; p.?; 2:10127084-10127084 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Unknown |
c.195C>T; p.P65P; 2:10123407-10123407 |
skin | malignant_melanoma | Substitution - coding silent |
c.412G>C; p.D138H; 2:10123829-10123829 |
NS | NS | Substitution - Missense |
c.364G>A; p.E122K; 2:10123781-10123781 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.926C>A; p.P309H; 2:10129063-10129063 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.519T>C; p.S173S; 2:10124800-10124800 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; polycythaemia_vera | Substitution - coding silent |
c.439G>C; p.E147Q; 2:10124720-10124720 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.945G>A; p.M315I; 2:10129082-10129082 |
skin | malignant_melanoma | Substitution - Missense |
c.945G>A; p.M315I; 2:10129082-10129082 |
breast | carcinoma | Substitution - Missense |
c.187G>T; p.A63S; 2:10123399-10123399 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.282_283insA; p.K96fs*48; 2:10123494-10123495 |
skin; mucosal | malignant_melanoma | Insertion - Frameshift |
c.427G>A; p.E143K; 2:10123844-10123844 |
breast | carcinoma; basal_(triple-negative)_carcinoma | Substitution - Missense |
c.75C>T; p.L25L; 2:10122873-10122873 |
cervix | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.44A>G; p.Q15R; 2:10122842-10122842 |
liver | carcinoma | Substitution - Missense |
c.44A>G; p.Q15R; 2:10122842-10122842 |
liver | carcinoma | Substitution - Missense |
c.612G>A; p.K204K; 2:10126917-10126917 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.834A>G; p.K278K; 2:10128883-10128883 |
breast | carcinoma | Substitution - coding silent |
c.423A>G; p.V141V; 2:10123840-10123840 |
parathyroid | adenoma | Substitution - coding silent |
c.893G>A; p.R298Q; 2:10128942-10128942 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.996G>A; p.M332I; 2:10129133-10129133 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.565G>A; p.E189K; 2:10124846-10124846 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.970A>G; p.I324V; 2:10129107-10129107 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.531_533delTCT; p.L179delL; 2:10124812-10124814 |
large_intestine; caecum | carcinoma; adenocarcinoma | Deletion - In frame |
c.196G>A; p.G66S; 2:10123408-10123408 |
lung | carcinoma; small_cell_carcinoma | Substitution - Missense |
c.219G>A; p.L73L; 2:10123431-10123431 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1030G>C; p.E344Q; 2:10129246-10129246 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.658A>C; p.T220P; 2:10126963-10126963 |
skin | malignant_melanoma | Substitution - Missense |
c.1036C>T; p.P346S; 2:10129252-10129252 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.397T>G; p.F133V; 2:10123814-10123814 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.266A>G; p.D89G; 2:10123478-10123478 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.904G>A; p.E302K; 2:10129041-10129041 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.541G>C; p.D181H; 2:10124822-10124822 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1145C>A; p.S382Y; 2:10129361-10129361 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.952A>G; p.T318A; 2:10129089-10129089 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1083C>A; p.F361L; 2:10129299-10129299 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.711C>T; p.S237S; 2:10127133-10127133 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.892C>T; p.R298W; 2:10128941-10128941 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.117G>A; p.G39G; 2:10123000-10123000 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.236G>T; p.R79L; 2:10123448-10123448 |
thyroid | other; neoplasm | Substitution - Missense |
c.579C>T; p.L193L; 2:10126884-10126884 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.551_552insA; p.D186fs*13; 2:10124832-10124833 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.1062A>T; p.S354S; 2:10129278-10129278 |
breast | carcinoma | Substitution - coding silent |
c.490T>C; p.F164L; 2:10124771-10124771 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.752T>C; p.L251P; 2:10127174-10127174 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.191delC; p.G66fs*8; 2:10123403-10123403 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.735G>T; p.W245C; 2:10127157-10127157 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.235C>T; p.R79C; 2:10123447-10123447 |
thyroid | other; neoplasm | Substitution - Missense |
c.971T>C; p.I324T; 2:10129108-10129108 |
breast | carcinoma; HER-positive_carcinoma | Substitution - Missense |
c.791G>C; p.R264T; 2:10127213-10127213 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.502A>G; p.M168V; 2:10124783-10124783 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.671G>A; p.R224H; 2:10127093-10127093 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.289G>A; p.A97T; 2:10123501-10123501 |
skin; neck | malignant_melanoma | Substitution - Missense |
c.1034A>C; p.N345T; 2:10129250-10129250 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.224A>G; p.E75G; 2:10123436-10123436 |
skin; extremity | malignant_melanoma | Substitution - Missense |
c.292G>C; p.E98Q; 2:10123504-10123504 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.320T>C; p.V107A; 2:10123737-10123737 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |