Entrez Gene

Basic Information
Gene ID	6197
Name	RPS6KA3
Synonymous	ribosomal protein S6 kinase, 90kDa, polypeptide 3;RPS6KA3;ribosomal protein S6 kinase, 90kDa, polypeptide 3
Definition	MAP kinase-activated protein kinase 1b\|MAPK-activated protein kinase 1b\|MAPKAP kinase 1b\|MAPKAPK-1b\|RSK-2\|S6K-alpha-3\|insulin-stimulated protein kinase 1\|p90-RSK 3\|ribosomal S6 kinase 2\|ribosomal protein S6 kinase alpha-3
Position	Xp22.2-p22.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.909C>G; p.F303L; 23:20177021-20177021	breast	carcinoma	Substitution - Missense
c.1240A>G; p.N414D; 23:20172859-20172859	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1240A>G; p.N414D; 23:20172859-20172859	oesophagus	carcinoma	Substitution - Missense
c.1710G>A; p.A570A; 23:20164953-20164953	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1720_1721insC; p.L574fs*23; 23:20164942-20164943	liver	carcinoma	Insertion - Frameshift
c.1247T>C; p.I416T; 23:20172852-20172852	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1156A>T; p.S386C; 23:20175235-20175235	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1247T>C; p.I416T; 23:20172852-20172852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.724C>T; p.R242C; 23:20187878-20187878	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.724C>T; p.R242C; 23:20187878-20187878	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1011A>G; p.R337R; 23:20176341-20176341	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1672C>T; p.R558*; 23:20164991-20164991	breast	carcinoma	Substitution - Nonsense
c.602T>C; p.L201P; 23:20188526-20188526	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2115T>A; p.A705A; 23:20155506-20155506	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1449T>C; p.Y483Y; 23:20167742-20167742	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2038G>A; p.V680I; 23:20156171-20156171	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2038G>A; p.V680I; 23:20156171-20156171	breast	carcinoma	Substitution - Missense
c.1824C>T; p.L608L; 23:20162981-20162981	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1449T>C; p.Y483Y; 23:20167742-20167742	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.750C>T; p.D250D; 23:20187852-20187852	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1914C>A; p.F638L; 23:20161689-20161689	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.977T>C; p.F326S; 23:20176456-20176456	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.213A>G; p.L71L; 23:20209318-20209318	prostate	adenoma	Substitution - coding silent
c.473G>A; p.R158H; 23:20194202-20194202	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.473G>A; p.R158H; 23:20194202-20194202	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.854T>C; p.L285P; 23:20177076-20177076	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1103-3C>G; p.?; 23:20175291-20175291	liver	carcinoma	Unknown
c.1103-3C>G; p.?; 23:20175291-20175291	liver	carcinoma	Unknown
c.1561T>C; p.F521L; 23:20167630-20167630	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1522C>A; p.Q508K; 23:20167669-20167669	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1824C>A; p.L608L; 23:20162981-20162981	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.73G>C; p.G25R; 23:20234811-20234811	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.378T>C; p.N126N; 23:20195093-20195093	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2103_2110delTGCCATGG; p.A702fs*9; 23:20155511-20155518	liver	carcinoma	Deletion - Frameshift
c.886C>T; p.Q296*; 23:20177044-20177044	liver	carcinoma	Substitution - Nonsense
c.1213C>T; p.H405Y; 23:20175178-20175178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1213C>T; p.H405Y; 23:20175178-20175178	large_intestine; colon	carcinoma	Substitution - Missense
c.290A>G; p.Y97C; 23:20204057-20204057	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1213C>T; p.H405Y; 23:20175178-20175178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1065C>A; p.F355L; 23:20176287-20176287	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1839C>A; p.T613T; 23:20162966-20162966	skin	malignant_melanoma	Substitution - coding silent
c.1480_1481delGA; p.E494fs*6; 23:20167710-20167711	liver	carcinoma	Deletion - Frameshift
c.2204_2205insA; p.T736fs*>6; 23:20155416-20155417	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.940G>T; p.G314*; 23:20176493-20176493	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.329G>A; p.R110Q; 23:20195142-20195142	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1842-2A>G; p.?; 23:20161763-20161763	liver	carcinoma	Unknown
c.1704G>A; p.L568L; 23:20164959-20164959	breast	carcinoma	Substitution - coding silent
c.1703T>A; p.L568Q; 23:20164960-20164960	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1142T>C; p.L381P; 23:20175249-20175249	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1142T>C; p.L381P; 23:20175249-20175249	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1142T>C; p.L381P; 23:20175249-20175249	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1118C>A; p.P373Q; 23:20175273-20175273	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1044G>T; p.T348T; 23:20176308-20176308	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.574A>G; p.R192G; 23:20193506-20193506	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.766G>T; p.V256L; 23:20187836-20187836	central_nervous_system; brain	glioma	Substitution - Missense
c.1386_1400>TGCTG; p.E462fs*15; 23:20169445-20169459	breast	carcinoma	Complex - frameshift
c.1448A>G; p.Y483C; 23:20167743-20167743	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1448A>G; p.Y483C; 23:20167743-20167743	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1448A>G; p.Y483C; 23:20167743-20167743	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2203delA; p.I735fs*>6; 23:20155418-20155418	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1448A>G; p.Y483C; 23:20167743-20167743	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2203delA; p.I735fs*>6; 23:20155418-20155418	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1448A>G; p.Y483C; 23:20167743-20167743	stomach	adenocarcinoma	Substitution - Missense
c.669G>T; p.K223N; 23:20187933-20187933	central_nervous_system; thalamus	glioma; oligoastrocytoma_Grade_III	Substitution - Missense
c.453G>T; p.R151S; 23:20194222-20194222	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1078G>C; p.E360Q; 23:20176274-20176274	urinary_tract; bladder	carcinoma	Substitution - Missense
c.996G>T; p.W332C; 23:20176437-20176437	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1307_1324del18; p.C436_K442>*; 23:20172775-20172792	liver	carcinoma	Complex - deletion inframe
c.1416G>C; p.Q472H; 23:20169429-20169429	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2027A>G; p.H676R; 23:20156182-20156182	liver	carcinoma	Substitution - Missense
c.423G>A; p.G141G; 23:20194252-20194252	skin	malignant_melanoma	Substitution - coding silent
c.340C>T; p.R114W; 23:20195131-20195131	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.340C>T; p.R114W; 23:20195131-20195131	breast	carcinoma	Substitution - Missense
c.1619_1622delTGAA; p.L540fs*28; 23:20165041-20165044	liver	carcinoma	Deletion - Frameshift
c.766G>A; p.V256M; 23:20187836-20187836	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2135G>A; p.R712H; 23:20155486-20155486	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.817C>T; p.R273*; 23:20186324-20186324	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.817C>T; p.R273*; 23:20186324-20186324	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1248T>C; p.I416I; 23:20172851-20172851	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1769T>G; p.L590*; 23:20163036-20163036	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.140T>G; p.I47S; 23:20209391-20209391	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1246A>G; p.I416V; 23:20172853-20172853	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1246A>G; p.I416V; 23:20172853-20172853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1890G>T; p.L630F; 23:20161713-20161713	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.798C>A; p.L266L; 23:20186343-20186343	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.516C>T; p.F172F; 23:20193564-20193564	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.11C>T; p.A4V; 23:20266622-20266622	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.294C>T; p.A98A; 23:20204053-20204053	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.845+4A>T; p.?; 23:20186292-20186292	liver	carcinoma	Unknown
c.2134C>T; p.R712C; 23:20155487-20155487	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.818G>A; p.R273Q; 23:20186323-20186323	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.244-1G>A; p.?; 23:20204104-20204104	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.818G>A; p.R273Q; 23:20186323-20186323	oesophagus	carcinoma	Substitution - Missense
c.845+4A>T; p.?; 23:20186292-20186292	liver	carcinoma	Unknown
c.1317T>C; p.C439C; 23:20172782-20172782	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.826A>G; p.T276A; 23:20186315-20186315	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1822C>T; p.L608F; 23:20162983-20162983	central_nervous_system; brain	glioma	Substitution - Missense
c.1822C>T; p.L608F; 23:20162983-20162983	central_nervous_system; brain	glioma	Substitution - Missense
c.1206_1209delTGGT; p.G403fs*21; 23:20175182-20175185	liver	carcinoma	Deletion - Frameshift
c.472C>T; p.R158C; 23:20194203-20194203	breast	carcinoma	Substitution - Missense
c.214A>C; p.K72Q; 23:20209317-20209317	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1602+1G>A; p.?; 23:20167588-20167588	liver	carcinoma	Unknown
c.1602+1G>A; p.?; 23:20167588-20167588	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.646A>G; p.K216E; 23:20187956-20187956	liver	carcinoma	Substitution - Missense
c.646A>G; p.K216E; 23:20187956-20187956	liver	carcinoma	Substitution - Missense
c.900A>G; p.R300R; 23:20177030-20177030	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1000-10delT; p.?; 23:20176362-20176362	liver	carcinoma	Unknown
c.1530T>G; p.F510L; 23:20167661-20167661	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1183G>A; p.E395K; 23:20175208-20175208	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.62G>T; p.S21I; 23:20266571-20266571	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.294delC; p.M99fs*1; 23:20204053-20204053	liver	carcinoma	Deletion - Frameshift
c.1405C>T; p.R469C; 23:20169440-20169440	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1062A>T; p.T354T; 23:20176290-20176290	breast	carcinoma; ductal_carcinoma	Substitution - coding silent
c.676T>A; p.Y226N; 23:20187926-20187926	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.892C>T; p.L298F; 23:20177038-20177038	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1141C>T; p.L381F; 23:20175250-20175250	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.334C>T; p.R112*; 23:20195137-20195137	liver	carcinoma	Substitution - Nonsense
c.334C>T; p.R112*; 23:20195137-20195137	liver	carcinoma	Substitution - Nonsense
c.334C>T; p.R112*; 23:20195137-20195137	liver	carcinoma	Substitution - Nonsense
c.334C>T; p.R112*; 23:20195137-20195137	liver	carcinoma	Substitution - Nonsense
c.363C>A; p.I121I; 23:20195108-20195108	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.533C>A; p.A178E; 23:20193547-20193547	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1613G>C; p.R538T; 23:20165050-20165050	liver	carcinoma	Substitution - Missense
c.1613G>C; p.R538T; 23:20165050-20165050	liver	carcinoma	Substitution - Missense
c.324delA; p.V109fs*15; 23:20204023-20204023	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1299_1304delCTCTGT; p.S434_V435delSV; 23:20172795-20172800	liver	carcinoma	Deletion - In frame
c.1877C>A; p.P626Q; 23:20161726-20161726	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.1046G>A; p.G349D; 23:20176306-20176306	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1593C>T; p.H531H; 23:20167598-20167598	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.594-1G>C; p.?; 23:20188535-20188535	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1881G>T; p.E627D; 23:20161722-20161722	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1142T>A; p.L381H; 23:20175249-20175249	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1142T>A; p.L381H; 23:20175249-20175249	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.278C>A; p.A93D; 23:20204069-20204069	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.114T>C; p.I38I; 23:20234770-20234770	skin	malignant_melanoma	Substitution - coding silent
c.328C>T; p.R110*; 23:20195143-20195143	breast	carcinoma	Substitution - Nonsense
c.328C>T; p.R110*; 23:20195143-20195143	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.314C>T; p.A105V; 23:20204033-20204033	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.314C>T; p.A105V; 23:20204033-20204033	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.752_753insG; p.W252fs*9; 23:20187849-20187850	liver	carcinoma	Insertion - Frameshift
c.2037C>T; p.I679I; 23:20156172-20156172	skin	malignant_melanoma	Substitution - coding silent
c.1582G>T; p.E528*; 23:20167609-20167609	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1265A>G; p.Y422C; 23:20172834-20172834	liver	carcinoma	Substitution - Missense
c.1265A>G; p.Y422C; 23:20172834-20172834	liver	carcinoma	Substitution - Missense
c.1200G>C; p.Q400H; 23:20175191-20175191	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.1579G>A; p.V527I; 23:20167612-20167612	breast	carcinoma	Substitution - Missense
c.899G>A; p.R300Q; 23:20177031-20177031	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.479C>T; p.S160F; 23:20194196-20194196	skin	malignant_melanoma	Substitution - Missense
c.748G>A; p.D250N; 23:20187854-20187854	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.528A>G; p.E176E; 23:20193552-20193552	skin	malignant_melanoma	Substitution - coding silent
c.1828_1836ACAATGCTT>G; p.T610fs*11; 23:20162969-20162977	liver	carcinoma; hepatocellular_carcinoma	Complex - frameshift
c.1594G>A; p.A532T; 23:20167597-20167597	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1758A>T; p.A586A; 23:20164905-20164905	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1840G>A; p.G614S; 23:20162965-20162965	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.434T>A; p.L145H; 23:20194241-20194241	liver	carcinoma	Substitution - Missense
c.434T>A; p.L145H; 23:20194241-20194241	liver	carcinoma	Substitution - Missense
c.434T>A; p.L145H; 23:20194241-20194241	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1476A>G; p.V492V; 23:20167715-20167715	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1727T>C; p.M576T; 23:20164936-20164936	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.910A>G; p.K304E; 23:20177020-20177020	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1516C>A; p.L506I; 23:20167675-20167675	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1516C>A; p.L506I; 23:20167675-20167675	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1388A>T; p.E463V; 23:20169457-20169457	liver	carcinoma	Substitution - Missense
c.1388A>T; p.E463V; 23:20169457-20169457	liver	carcinoma	Substitution - Missense
c.1533C>A; p.F511L; 23:20167658-20167658	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1750T>G; p.F584V; 23:20164913-20164913	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.745G>A; p.A249T; 23:20187857-20187857	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1595C>T; p.A532V; 23:20167596-20167596	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1955C>A; p.A652E; 23:20161648-20161648	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1636_1638CTT>G; p.L546fs*4; 23:20165025-20165027	liver	carcinoma; hepatocellular_carcinoma	Complex - frameshift
c.1816G>A; p.V606I; 23:20162989-20162989	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]