Entrez Gene

Basic Information
Gene ID	4605
Name	MYBL2
Synonymous	v-myb avian myeloblastosis viral oncogene homolog-like 2;MYBL2;v-myb avian myeloblastosis viral oncogene homolog-like 2
Definition	myb-like protein 2\|myb-related protein B\|v-myb myeloblastosis viral oncogene homolog-like 2
Position	20q13.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1596G>C; p.L532L; 20:43710053-43710053	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1596G>C; p.L532L; 20:43710053-43710053	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1900G>A; p.G634S; 20:43715209-43715209	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.513_514TG>CC; p.V172L; 20:43692169-43692170	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1684G>A; p.D562N; 20:43711566-43711566	skin	malignant_melanoma	Substitution - Missense
c.1969G>A; p.A657T; 20:43715278-43715278	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1086C>T; p.S362S; 20:43702624-43702624	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1180C>T; p.P394S; 20:43702718-43702718	kidney	carcinoma	Substitution - Missense
c.1220C>T; p.P407L; 20:43702758-43702758	skin	malignant_melanoma	Substitution - Missense
c.509A>G; p.N170S; 20:43692165-43692165	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.951G>A; p.S317S; 20:43700044-43700044	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.951G>A; p.S317S; 20:43700044-43700044	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1884C>T; p.N628N; 20:43715193-43715193	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2055G>T; p.L685L; 20:43716039-43716039	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.619G>A; p.E207K; 20:43692275-43692275	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.1369C>T; p.L457L; 20:43705222-43705222	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.172_173insC; p.S59fs*5; 20:43681841-43681842	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.172_173insC; p.S59fs*5; 20:43681841-43681842	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1897C>T; p.Q633*; 20:43715206-43715206	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1746C>T; p.V582V; 20:43713028-43713028	skin	malignant_melanoma	Substitution - coding silent
c.1356G>A; p.S452S; 20:43702894-43702894	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1356G>A; p.S452S; 20:43702894-43702894	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1356G>A; p.S452S; 20:43702894-43702894	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1356G>A; p.S452S; 20:43702894-43702894	large_intestine; caecum	adenoma	Substitution - coding silent
c.1554G>T; p.T518T; 20:43710011-43710011	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.371G>A; p.R124H; 20:43686943-43686943	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1156C>T; p.R386W; 20:43702694-43702694	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.1288C>T; p.L430L; 20:43702826-43702826	skin	malignant_melanoma	Substitution - coding silent
c.1931C>T; p.A644V; 20:43715240-43715240	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1979C>T; p.S660F; 20:43715963-43715963	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1979C>T; p.S660F; 20:43715963-43715963	skin	malignant_melanoma	Substitution - Missense
c.602A>G; p.Y201C; 20:43692258-43692258	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2062C>T; p.L688L; 20:43716046-43716046	skin	malignant_melanoma	Substitution - coding silent
c.1068G>A; p.L356L; 20:43702606-43702606	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1561C>T; p.P521S; 20:43710018-43710018	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1892T>C; p.L631P; 20:43715201-43715201	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1541A>T; p.N514I; 20:43709998-43709998	breast	carcinoma	Substitution - Missense
c.129G>T; p.R43S; 20:43681798-43681798	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.129G>T; p.R43S; 20:43681798-43681798	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1262_1263CC>TT; p.S421F; 20:43702800-43702801	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.22G>A; p.E8K; 20:43673807-43673807	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1644G>T; p.V548V; 20:43711526-43711526	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.864G>T; p.L288L; 20:43699957-43699957	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.591G>T; p.K197N; 20:43692247-43692247	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1279A>G; p.S427G; 20:43702817-43702817	thyroid	other; neoplasm	Substitution - Missense
c.2083C>T; p.R695W; 20:43716067-43716067	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1514C>T; p.T505I; 20:43709971-43709971	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193A>G; p.T65A; 20:43682800-43682800	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1088C>T; p.A363V; 20:43702626-43702626	skin	malignant_melanoma	Substitution - Missense
c.1463C>G; p.P488R; 20:43705316-43705316	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1558A>G; p.T520A; 20:43710015-43710015	liver	carcinoma	Substitution - Missense
c.631G>A; p.G211S; 20:43692287-43692287	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1249C>T; p.R417C; 20:43702787-43702787	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1255G>T; p.A419S; 20:43702793-43702793	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1820C>T; p.S607F; 20:43713102-43713102	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1820C>T; p.S607F; 20:43713102-43713102	skin	malignant_melanoma	Substitution - Missense
c.1949G>A; p.R650Q; 20:43715258-43715258	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1949G>A; p.R650Q; 20:43715258-43715258	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1851C>T; p.S617S; 20:43715160-43715160	breast	carcinoma	Substitution - coding silent
c.991C>T; p.P331S; 20:43702529-43702529	skin	malignant_melanoma	Substitution - Missense
c.1114C>T; p.R372C; 20:43702652-43702652	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1805T>C; p.L602P; 20:43713087-43713087	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.846C>T; p.S282S; 20:43699939-43699939	skin	malignant_melanoma	Substitution - coding silent
c.907G>A; p.A303T; 20:43700000-43700000	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1805T>C; p.L602P; 20:43713087-43713087	liver	carcinoma	Substitution - Missense
c.1693C>T; p.P565S; 20:43711575-43711575	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.787G>A; p.A263T; 20:43699880-43699880	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1872C>G; p.I624M; 20:43715181-43715181	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.752C>T; p.S251L; 20:43699845-43699845	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.215G>A; p.R72K; 20:43682822-43682822	breast	carcinoma	Substitution - Missense
c.366T>C; p.R122R; 20:43686938-43686938	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.380A>C; p.N127T; 20:43686952-43686952	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.473C>T; p.A158V; 20:43687045-43687045	skin	malignant_melanoma	Substitution - Missense
c.1300G>T; p.D434Y; 20:43702838-43702838	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1280G>A; p.S427N; 20:43702818-43702818	liver	carcinoma	Substitution - Missense
c.277A>C; p.K93Q; 20:43682884-43682884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.693C>T; p.V231V; 20:43699786-43699786	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.693C>T; p.V231V; 20:43699786-43699786	skin	malignant_melanoma	Substitution - coding silent
c.1542C>A; p.N514K; 20:43709999-43709999	breast	carcinoma	Substitution - Missense
c.68C>T; p.P23L; 20:43673853-43673853	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1365+1_1365+2insT; p.?; 20:43702904-43702905	lung	carcinoma; small_cell_carcinoma	Unknown
c.1250G>A; p.R417H; 20:43702788-43702788	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.979A>G; p.K327E; 20:43702517-43702517	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2028C>T; p.F676F; 20:43716012-43716012	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2028C>T; p.F676F; 20:43716012-43716012	skin	malignant_melanoma	Substitution - coding silent
c.1415C>T; p.S472L; 20:43705268-43705268	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1648C>T; p.R550C; 20:43711530-43711530	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1989G>A; p.W663*; 20:43715973-43715973	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1989G>A; p.W663*; 20:43715973-43715973	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1808C>T; p.P603L; 20:43713090-43713090	skin	malignant_melanoma	Substitution - Missense
c.2003G>T; p.C668F; 20:43715987-43715987	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.191G>A; p.R64H; 20:43682798-43682798	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1562C>T; p.P521L; 20:43710019-43710019	skin	malignant_melanoma	Substitution - Missense
c.1652C>T; p.S551F; 20:43711534-43711534	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.542A>C; p.K181T; 20:43692198-43692198	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1075C>T; p.R359C; 20:43702613-43702613	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1075C>T; p.R359C; 20:43702613-43702613	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1002A>G; p.P334P; 20:43702540-43702540	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1596G>A; p.L532L; 20:43710053-43710053	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1847C>A; p.S616Y; 20:43715156-43715156	breast	carcinoma	Substitution - Missense
c.1931C>A; p.A644E; 20:43715240-43715240	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.908C>T; p.A303V; 20:43700001-43700001	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.126G>T; p.L42L; 20:43681795-43681795	prostate	carcinoma	Substitution - coding silent
c.1573G>A; p.A525T; 20:43710030-43710030	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.163A>G; p.K55E; 20:43681832-43681832	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.153G>A; p.Q51Q; 20:43681822-43681822	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.392C>A; p.P131H; 20:43686964-43686964	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1198G>T; p.G400C; 20:43702736-43702736	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1182_1183CA>TT; p.S395C; 20:43702720-43702721	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1995G>A; p.T665T; 20:43715979-43715979	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1273G>A; p.E425K; 20:43702811-43702811	thyroid	carcinoma	Substitution - Missense
c.696T>C; p.P232P; 20:43699789-43699789	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.261C>A; p.T87T; 20:43682868-43682868	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - coding silent
c.2049G>T; p.Q683H; 20:43716033-43716033	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.992C>A; p.P331H; 20:43702530-43702530	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.438C>T; p.I146I; 20:43687010-43687010	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1888T>C; p.L630L; 20:43715197-43715197	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.534T>C; p.S178S; 20:43692190-43692190	prostate	carcinoma	Substitution - coding silent
c.630C>T; p.D210D; 20:43692286-43692286	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.638A>T; p.Q213L; 20:43692294-43692294	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; essential_thrombocythaemia	Substitution - Missense
c.865C>T; p.P289S; 20:43699958-43699958	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2056G>T; p.G686C; 20:43716040-43716040	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1936G>T; p.A646S; 20:43715245-43715245	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1007C>A; p.A336E; 20:43702545-43702545	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.753G>A; p.S251S; 20:43699846-43699846	skin	malignant_melanoma	Substitution - coding silent
c.330_331insA; p.H112fs*12; 20:43686902-43686903	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1516C>T; p.P506S; 20:43709973-43709973	skin	malignant_melanoma	Substitution - Missense
c.1719G>A; p.G573G; 20:43711601-43711601	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1211G>A; p.G404D; 20:43702749-43702749	skin	malignant_melanoma	Substitution - Missense
c.1323C>T; p.P441P; 20:43702861-43702861	skin	malignant_melanoma	Substitution - coding silent
c.241C>A; p.L81I; 20:43682848-43682848	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.609G>A; p.L203L; 20:43692265-43692265	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1328G>A; p.S443N; 20:43702866-43702866	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1328G>A; p.S443N; 20:43702866-43702866	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.621G>T; p.E207D; 20:43692277-43692277	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1657G>T; p.A553S; 20:43711539-43711539	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1505C>T; p.A502V; 20:43705358-43705358	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1085C>T; p.S362F; 20:43702623-43702623	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1251T>C; p.R417R; 20:43702789-43702789	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.903C>T; p.I301I; 20:43699996-43699996	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.316T>C; p.W106R; 20:43686888-43686888	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1194C>T; p.V398V; 20:43702732-43702732	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1213A>G; p.T405A; 20:43702751-43702751	skin	malignant_melanoma	Substitution - Missense
c.1962G>A; p.T654T; 20:43715271-43715271	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1554G>A; p.T518T; 20:43710011-43710011	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1962G>A; p.T654T; 20:43715271-43715271	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.249G>T; p.K83N; 20:43682856-43682856	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1962G>A; p.T654T; 20:43715271-43715271	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1962G>A; p.T654T; 20:43715271-43715271	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Substitution - coding silent
c.187-10C>G; p.?; 20:43682784-43682784	ovary	other; neoplasm	Unknown
c.861C>A; p.S287R; 20:43699954-43699954	skin	malignant_melanoma	Substitution - Missense
c.861C>A; p.S287R; 20:43699954-43699954	skin	malignant_melanoma	Substitution - Missense
c.1000C>T; p.P334S; 20:43702538-43702538	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1666G>A; p.E556K; 20:43711548-43711548	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1666G>A; p.E556K; 20:43711548-43711548	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1666G>A; p.E556K; 20:43711548-43711548	breast	carcinoma	Substitution - Missense
c.2084G>A; p.R695Q; 20:43716068-43716068	skin	malignant_melanoma	Substitution - Missense
c.1536G>T; p.M512I; 20:43709993-43709993	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1483C>T; p.P495S; 20:43705336-43705336	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1320G>A; p.T440T; 20:43702858-43702858	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.690C>T; p.S230S; 20:43699783-43699783	stomach	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]