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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

4092

Name

SMAD7

Synonymous

SMAD family member 7;SMAD7;SMAD family member 7

Definition

MAD (mothers against decapentaplegic, Drosophila) homolog 7|MAD homolog 8|Mothers against decapentaplegic, drosophila, homolog of, 7|SMAD, mothers against DPP homolog 7|hSMAD7|mothers against DPP homolog 8|mothers against decapentaplegic homolog 7

Position

18q21.1

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.714G>A; p.T238T; 18:48942509-48942509

 skinmalignant_melanomaSubstitution - coding silent

c.1173G>A; p.T391T; 18:48921480-48921480

 skinmalignant_melanomaSubstitution - coding silent

c.1136G>A; p.R379Q; 18:48921517-48921517

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1207T>G; p.W403G; 18:48921446-48921446

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1207T>G; p.W403G; 18:48921446-48921446

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1207T>G; p.W403G; 18:48921446-48921446

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1207T>G; p.W403G; 18:48921446-48921446

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.971C>T; p.T324M; 18:48921682-48921682

 prostatecarcinomaSubstitution - Missense

c.480C>A; p.C160*; 18:48949945-48949945

 ovarycarcinoma; serous_carcinomaSubstitution - Nonsense

c.717T>A; p.N239K; 18:48942506-48942506

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.545C>G; p.S182C; 18:48949880-48949880

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.813G>A; p.T271T; 18:48921840-48921840

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1050_1051GG>TT; p.D351Y; 18:48921602-48921603

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1212C>T; p.G404G; 18:48921441-48921441

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.578G>A; p.C193Y; 18:48949847-48949847

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.432G>A; p.A144A; 18:48949993-48949993

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.786C>T; p.C262C; 18:48921867-48921867

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.624C>A; p.P208P; 18:48948427-48948427

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.1069G>A; p.V357I; 18:48921584-48921584

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.618T>C; p.S206S; 18:48948433-48948433

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.626delC; p.P209fs*115; 18:48948425-48948425

 large_intestine; rectumcarcinoma; adenocarcinomaDeletion - Frameshift

c.626delC; p.P209fs*115; 18:48948425-48948425

 stomachcarcinoma; intestinal_adenocarcinomaDeletion - Frameshift

c.626delC; p.P209fs*115; 18:48948425-48948425

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1121C>T; p.A374V; 18:48921532-48921532

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1273_1274insC; p.S425fs*>3; 18:48921379-48921380

 central_nervous_system; brainglioma; astrocytoma_Grade_IVInsertion - Frameshift

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 thyroidother; neoplasmSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>C; p.T408P; 18:48921431-48921431

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.636C>T; p.S212S; 18:48948415-48948415

 skinmalignant_melanomaSubstitution - coding silent

c.957C>A; p.C319*; 18:48921696-48921696

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.626_627insC; p.P210fs*25; 18:48948424-48948425

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.626_627insC; p.P210fs*25; 18:48948424-48948425

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.626_627insC; p.P210fs*25; 18:48948424-48948425

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.1181C>T; p.T394I; 18:48921472-48921472

 skinmalignant_melanomaSubstitution - Missense

c.1181C>T; p.T394I; 18:48921472-48921472

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1181C>T; p.T394I; 18:48921472-48921472

 skinmalignant_melanomaSubstitution - Missense

c.985G>A; p.G329S; 18:48921668-48921668

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.629C>G; p.P210R; 18:48948422-48948422

 livercarcinomaSubstitution - Missense

c.629C>G; p.P210R; 18:48948422-48948422

 livercarcinomaSubstitution - Missense

c.787G>A; p.V263M; 18:48921866-48921866

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.693C>T; p.S231S; 18:48942530-48942530

 skinmalignant_melanomaSubstitution - coding silent

c.1032C>T; p.S344S; 18:48921621-48921621

 skinmalignant_melanomaSubstitution - coding silent

c.568C>T; p.L190L; 18:48949857-48949857

 ovaryother; neoplasmSubstitution - coding silent

c.1150G>A; p.E384K; 18:48921503-48921503

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.765T>C; p.P255P; 18:48921888-48921888

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.930G>A; p.V310V; 18:48921723-48921723

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1004G>A; p.R335H; 18:48921649-48921649

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1004G>A; p.R335H; 18:48921649-48921649

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.941G>A; p.R314Q; 18:48921712-48921712

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.336C>T; p.L112L; 18:48950089-48950089

 pancreascarcinomaSubstitution - coding silent

c.1177T>A; p.F393I; 18:48921476-48921476

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.667G>T; p.A223S; 18:48948384-48948384

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.565G>T; p.E189*; 18:48949860-48949860

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.135C>T; p.S45S; 18:48950290-48950290

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.667+8G>A; p.?; 18:48948376-48948376

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaUnknown

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