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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

23410

Name

SIRT3

Synonymous

sirtuin 3;SIRT3;sirtuin 3

Definition

NAD-dependent deacetylase sirtuin-3, mitochondrial|NAD-dependent protein deacetylase sirtuin-3, mitochondrial|SIR2-like protein 3|mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase|regulatory protein SIR2 homolog 3|silent mating type in

Position

11p15.5

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.6G>A; p.A2A; 11:236323-236323

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_B_cell_leukaemiaSubstitution - coding silent

c.516T>G; p.D172E; 11:233173-233173

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.516T>G; p.D172E; 11:233173-233173

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.45G>T; p.W15C; 11:236284-236284

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.785C>T; p.P262L; 11:230474-230474

 breastcarcinomaSubstitution - Missense

c.1179G>A; p.K393K; 11:218832-218832

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1104C>T; p.H368H; 11:218907-218907

 oesophaguscarcinomaSubstitution - coding silent

c.1015C>T; p.P339S; 11:218996-218996

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.366G>T; p.K122N; 11:233450-233450

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.120T>A; p.L40L; 11:236209-236209

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.862A>G; p.K288E; 11:224185-224185

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.793G>T; p.G265W; 11:230466-230466

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.649C>A; p.H217N; 11:233040-233040

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.490C>A; p.L164M; 11:233199-233199

 breastcarcinomaSubstitution - Missense

c.504C>T; p.L168L; 11:233185-233185

 skinmalignant_melanomaSubstitution - coding silent

c.996G>T; p.E332D; 11:219015-219015

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.399G>T; p.R133R; 11:233417-233417

 lungcarcinoma; small_cell_carcinomaSubstitution - coding silent

c.436delG; p.A146fs*127; 11:233380-233380

 large_intestine; rectumcarcinoma; adenocarcinomaDeletion - Frameshift

c.561C>A; p.H187Q; 11:233128-233128

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1168G>A; p.E390K; 11:218843-218843

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.529G>A; p.E177K; 11:233160-233160

 skinmalignant_melanomaSubstitution - Missense

c.986G>A; p.S329N; 11:219025-219025

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1167G>T; p.R389R; 11:218844-218844

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.7T>G; p.F3V; 11:236322-236322

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_B_cell_leukaemiaSubstitution - Missense

c.540delT; p.F180fs*93; 11:233149-233149

 oesophaguscarcinoma; adenocarcinomaDeletion - Frameshift

c.874G>T; p.V292L; 11:224173-224173

 breastcarcinomaSubstitution - Missense

c.1080G>T; p.V360V; 11:218931-218931

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1150C>A; p.R384R; 11:218861-218861

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1033C>T; p.R345W; 11:218978-218978

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.985A>G; p.S329G; 11:219026-219026

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.636_637insT; p.L213fs*6; 11:233052-233053

 skin; lower_legmalignant_melanomaInsertion - Frameshift

c.176A>C; p.E59A; 11:236153-236153

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.808-4C>G; p.?; 11:224243-224243

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaUnknown

c.322G>A; p.A108T; 11:233494-233494

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1107C>T; p.G369G; 11:218904-218904

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.659G>T; p.G220V; 11:233030-233030

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.292G>A; p.G98R; 11:233524-233524

 skinmalignant_melanomaSubstitution - Missense

c.952C>T; p.L318F; 11:224095-224095

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1037A>T; p.D346V; 11:218974-218974

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.1037A>T; p.D346V; 11:218974-218974

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1126C>A; p.L376I; 11:218885-218885

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.969+7C>T; p.?; 11:224071-224071

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaUnknown

c.552C>T; p.F184F; 11:233137-233137

 bone; tibiaEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.872T>G; p.I291S; 11:224175-224175

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1154A>C; p.D385A; 11:218857-218857

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.455G>A; p.S152N; 11:233361-233361

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.505C>T; p.Q169*; 11:233184-233184

 skinmalignant_melanomaSubstitution - Nonsense

c.1178A>G; p.K393R; 11:218833-218833

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1034G>A; p.R345Q; 11:218977-218977

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.978T>G; p.P326P; 11:219033-219033

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.513C>T; p.Y171Y; 11:233176-233176

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.856G>A; p.V286I; 11:224191-224191

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

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