Entrez Gene

Basic Information
Gene ID	1191
Name	CLU
Synonymous	clusterin;CLU;clusterin
Definition	aging-associated protein 4\|apolipoprotein J\|complement cytolysis inhibitor\|complement lysis inhibitor\|complement-associated protein SP-40,40\|ku70-binding protein 1\|sulfated glycoprotein 2\|testosterone-repressed prostate message 2
Position	8p21-p12
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1490delA; p.K497fs*>5; 8:27598466-27598466	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1322T>C; p.V441A; 8:27598634-27598634	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1401C>T; p.I467I; 8:27598555-27598555	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.849C>G; p.P283P; 8:27605060-27605060	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1439C>A; p.P480H; 8:27598517-27598517	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1413C>T; p.V471V; 8:27598543-27598543	skin	malignant_melanoma	Substitution - coding silent
c.1329C>T; p.S443S; 8:27598627-27598627	skin	malignant_melanoma	Substitution - coding silent
c.1294G>A; p.D432N; 8:27599806-27599806	skin	malignant_melanoma	Substitution - Missense
c.978C>T; p.F326F; 8:27604931-27604931	skin	malignant_melanoma	Substitution - coding silent
c.861C>T; p.Y287Y; 8:27605048-27605048	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.818C>T; p.P273L; 8:27605091-27605091	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.186G>A; p.G62G; 8:27610542-27610542	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.802C>A; p.P268T; 8:27605107-27605107	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1291G>A; p.E431K; 8:27599809-27599809	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1145C>A; p.S382Y; 8:27599955-27599955	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.729C>T; p.F243F; 8:27605180-27605180	skin	malignant_melanoma	Substitution - coding silent
c.526T>A; p.F176I; 8:27606401-27606401	skin	malignant_melanoma	Substitution - Missense
c.801G>A; p.R267R; 8:27605108-27605108	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1351C>T; p.P451S; 8:27598605-27598605	skin	malignant_melanoma	Substitution - Missense
c.702C>T; p.R234R; 8:27605207-27605207	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.741C>A; p.F247L; 8:27605168-27605168	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1141G>A; p.E381K; 8:27599959-27599959	skin	malignant_melanoma	Substitution - Missense
c.1141G>A; p.E381K; 8:27599959-27599959	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.824C>T; p.S275F; 8:27605085-27605085	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.352G>A; p.E118K; 8:27608988-27608988	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1098C>T; p.S366S; 8:27600002-27600002	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1137C>T; p.L379L; 8:27599963-27599963	skin	malignant_melanoma	Substitution - coding silent
c.1137C>T; p.L379L; 8:27599963-27599963	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.835C>T; p.R279C; 8:27605074-27605074	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.835C>T; p.R279C; 8:27605074-27605074	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.119C>T; p.P40L; 8:27614663-27614663	pancreas	carcinoma	Substitution - Missense
c.965C>T; p.P322L; 8:27604944-27604944	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.965C>T; p.P322L; 8:27604944-27604944	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.965C>T; p.P322L; 8:27604944-27604944	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.295C>A; p.Q99K; 8:27609045-27609045	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1035G>A; p.T345T; 8:27604346-27604346	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.466G>A; p.E156K; 8:27606461-27606461	skin	malignant_melanoma	Substitution - Missense
c.409C>A; p.L137I; 8:27606518-27606518	skin	malignant_melanoma	Substitution - Missense
c.856C>A; p.P286T; 8:27605053-27605053	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.139G>T; p.D47Y; 8:27610589-27610589	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.232G>A; p.V78I; 8:27610496-27610496	skin	malignant_melanoma	Substitution - Missense
c.827G>A; p.R276H; 8:27605082-27605082	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.827G>A; p.R276H; 8:27605082-27605082	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.110A>G; p.H37R; 8:27614672-27614672	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1484G>A; p.R495H; 8:27598472-27598472	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.313G>T; p.V105L; 8:27609027-27609027	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1469C>T; p.A490V; 8:27598487-27598487	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1284G>A; p.T428T; 8:27599816-27599816	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1284G>A; p.T428T; 8:27599816-27599816	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.991G>C; p.D331H; 8:27604390-27604390	skin	malignant_melanoma	Substitution - Missense
c.1018A>G; p.I340V; 8:27604363-27604363	breast	carcinoma	Substitution - Missense
c.748C>T; p.R250W; 8:27605161-27605161	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.748C>T; p.R250W; 8:27605161-27605161	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1294G>C; p.D432H; 8:27599806-27599806	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.655C>A; p.R219R; 8:27605254-27605254	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.588G>A; p.L196L; 8:27605321-27605321	skin	malignant_melanoma	Substitution - coding silent
c.744C>T; p.F248F; 8:27605165-27605165	skin	malignant_melanoma	Substitution - coding silent
c.231G>T; p.T77T; 8:27610497-27610497	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.744C>T; p.F248F; 8:27605165-27605165	skin	malignant_melanoma	Substitution - coding silent
c.1197C>T; p.S399S; 8:27599903-27599903	skin	malignant_melanoma	Substitution - coding silent
c.858G>A; p.P286P; 8:27605051-27605051	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.858G>A; p.P286P; 8:27605051-27605051	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1267C>T; p.R423W; 8:27599833-27599833	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1495C>T; p.R499W; 8:27598461-27598461	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.1495C>T; p.R499W; 8:27598461-27598461	skin	malignant_melanoma	Substitution - Missense
c.537C>T; p.R179R; 8:27606390-27606390	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.862G>A; p.E288K; 8:27605047-27605047	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.813C>T; p.F271F; 8:27605096-27605096	skin	malignant_melanoma	Substitution - coding silent
c.1183G>A; p.E395K; 8:27599917-27599917	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1140C>T; p.D380D; 8:27599960-27599960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1183G>A; p.E395K; 8:27599917-27599917	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1436A>C; p.N479T; 8:27598520-27598520	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.143C>T; p.S48F; 8:27610585-27610585	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.256A>G; p.M86V; 8:27609084-27609084	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.647A>G; p.E216G; 8:27605262-27605262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1127G>A; p.R376Q; 8:27599973-27599973	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.994G>A; p.D332N; 8:27604387-27604387	skin	malignant_melanoma	Substitution - Missense
c.898C>T; p.L300F; 8:27605011-27605011	skin	malignant_melanoma	Substitution - Missense
c.1226C>T; p.S409F; 8:27599874-27599874	skin	malignant_melanoma	Substitution - Missense
c.945T>C; p.H315H; 8:27604964-27604964	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.836G>A; p.R279H; 8:27605073-27605073	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.824C>A; p.S275Y; 8:27605085-27605085	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.343_344insA; p.T115fs*25; 8:27608996-27608997	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1445T>G; p.F482C; 8:27598511-27598511	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.932A>T; p.D311V; 8:27604977-27604977	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.522G>A; p.M174I; 8:27606405-27606405	skin	malignant_melanoma	Substitution - Missense
c.1107C>A; p.N369K; 8:27599993-27599993	thyroid	other; neoplasm	Substitution - Missense
c.1476G>A; p.Q492Q; 8:27598480-27598480	skin	malignant_melanoma	Substitution - coding silent
c.123G>A; p.L41L; 8:27614659-27614659	liver	carcinoma	Substitution - coding silent
c.721G>A; p.E241K; 8:27605188-27605188	skin	malignant_melanoma	Substitution - Missense
c.828C>T; p.R276R; 8:27605081-27605081	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.921G>T; p.Q307H; 8:27604988-27604988	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.310G>A; p.G104R; 8:27609030-27609030	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.856C>T; p.P286S; 8:27605053-27605053	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.856C>T; p.P286S; 8:27605053-27605053	skin	malignant_melanoma	Substitution - Missense
c.921G>T; p.Q307H; 8:27604988-27604988	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1465A>T; p.K489*; 8:27598491-27598491	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Nonsense
c.1420G>T; p.E474*; 8:27598536-27598536	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1114C>T; p.Q372*; 8:27599986-27599986	breast	carcinoma	Substitution - Nonsense
c.519C>T; p.C173C; 8:27606408-27606408	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.254A>G; p.E85G; 8:27609086-27609086	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.103_121del19; p.R35fs*1; 8:27614661-27614679	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - Frameshift
c.966G>A; p.P322P; 8:27604943-27604943	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.666G>A; p.T222T; 8:27605243-27605243	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.666G>A; p.T222T; 8:27605243-27605243	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.666G>A; p.T222T; 8:27605243-27605243	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1159G>A; p.E387K; 8:27599941-27599941	kidney	other; neoplasm	Substitution - Missense
c.1470G>A; p.A490A; 8:27598486-27598486	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1370T>G; p.V457G; 8:27598586-27598586	breast	carcinoma	Substitution - Missense
c.281T>C; p.V94A; 8:27609059-27609059	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.536G>A; p.R179H; 8:27606391-27606391	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.857C>T; p.P286L; 8:27605052-27605052	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.392A>T; p.K131M; 8:27608948-27608948	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.417G>T; p.E139D; 8:27606510-27606510	lung	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]