Cell senescence gene database Home
Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

1111

Name

CHEK1

Synonymous

checkpoint kinase 1;CHEK1;checkpoint kinase 1

Definition

CHK1 checkpoint homolog|Checkpoint, S. pombe, homolog of, 1|Chk1-S|cell cycle checkpoint kinase|checkpoint kinase-1|serine/threonine-protein kinase Chk1

Position

11q24.2

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.479G>A; p.R160H; 11:125633217-125633217

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.479G>A; p.R160H; 11:125633217-125633217

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.479G>A; p.R160H; 11:125633217-125633217

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.351G>T; p.G117G; 11:125629293-125629293

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.668A>C; p.E223A; 11:125635483-125635483

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1324C>T; p.R442W; 11:125653836-125653836

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.355G>C; p.V119L; 11:125629391-125629391

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.364C>T; p.H122Y; 11:125629400-125629400

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.96A>C; p.E32D; 11:125627637-125627637

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.703G>T; p.D235Y; 11:125635518-125635518

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.297delC; p.D99fs*2; 11:125629239-125629239

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.717A>G; p.L239L; 11:125635532-125635532

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.424+5G>T; p.?; 11:125629465-125629465

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.41C>A; p.T14N; 11:125626809-125626809

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.388G>T; p.D130Y; 11:125629424-125629424

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1054C>T; p.H352Y; 11:125644221-125644221

 skin; nipplemalignant_melanomaSubstitution - Missense

c.942C>T; p.Y314Y; 11:125644109-125644109

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.851C>T; p.S284L; 11:125643828-125643828

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.675A>G; p.K225K; 11:125635490-125635490

 livercarcinomaSubstitution - coding silent

c.675A>G; p.K225K; 11:125635490-125635490

 livercarcinomaSubstitution - coding silent

c.61G>A; p.G21R; 11:125626829-125626829

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.934G>A; p.V312M; 11:125644101-125644101

 thyroidcarcinomaSubstitution - Missense

c.498G>T; p.K166N; 11:125633236-125633236

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.693_694insA; p.I234fs*11; 11:125635508-125635509

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.1006G>A; p.D336N; 11:125644173-125644173

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.121G>A; p.D41N; 11:125627662-125627662

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.887C>T; p.S296F; 11:125643864-125643864

 skinmalignant_melanomaSubstitution - Missense

c.865G>T; p.G289*; 11:125643842-125643842

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.22G>A; p.D8N; 11:125626790-125626790

 breastcarcinomaSubstitution - Missense

c.1091G>T; p.G364V; 11:125644258-125644258

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.703G>A; p.D235N; 11:125635518-125635518

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.423G>T; p.R141S; 11:125629459-125629459

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.958G>A; p.E320K; 11:125644125-125644125

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1390G>T; p.D464Y; 11:125655279-125655279

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.480T>C; p.R160R; 11:125633218-125633218

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.480T>C; p.R160R; 11:125633218-125633218

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1408A>T; p.K470*; 11:125655297-125655297

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.478C>T; p.R160C; 11:125633216-125633216

 skinmalignant_melanomaSubstitution - Missense

c.1315G>C; p.V439L; 11:125653827-125653827

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.2T>C; p.M1T; 11:125626770-125626770

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.400G>A; p.E134K; 11:125629436-125629436

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.745A>C; p.N249H; 11:125637475-125637475

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.187A>C; p.N63H; 11:125627728-125627728

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.187A>C; p.N63H; 11:125627728-125627728

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.187A>C; p.N63H; 11:125627728-125627728

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.959A>G; p.E320G; 11:125644126-125644126

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.993C>T; p.S331S; 11:125644160-125644160

 thyroidcarcinoma; anaplastic_carcinomaSubstitution - coding silent

c.993C>T; p.S331S; 11:125644160-125644160

 thyroidcarcinoma; anaplastic_carcinomaSubstitution - coding silent

c.696A>T; p.K232N; 11:125635511-125635511

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.696A>T; p.K232N; 11:125635511-125635511

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.698A>C; p.K233T; 11:125635513-125635513

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.137T>C; p.V46A; 11:125627678-125627678

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.702C>T; p.I234I; 11:125635517-125635517

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.668delA; p.T226fs*14; 11:125635483-125635483

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.668delA; p.T226fs*14; 11:125635483-125635483

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.668delA; p.T226fs*14; 11:125635483-125635483

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.668delA; p.T226fs*14; 11:125635483-125635483

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.668delA; p.T226fs*14; 11:125635483-125635483

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.667_668insA; p.T226fs*19; 11:125635482-125635483

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.1013T>C; p.L338S; 11:125644180-125644180

 oesophaguscarcinomaSubstitution - Missense

c.667_668insA; p.T226fs*19; 11:125635482-125635483

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.505G>A; p.G169S; 11:125633243-125633243

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.466C>T; p.R156W; 11:125633204-125633204

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1082G>A; p.G361D; 11:125644249-125644249

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1078C>T; p.L360F; 11:125644245-125644245

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.430C>T; p.L144F; 11:125633168-125633168

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.432C>A; p.L144L; 11:125633170-125633170

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1204T>C; p.Y402H; 11:125644614-125644614

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1079T>C; p.L360P; 11:125644246-125644246

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.277T>G; p.F93V; 11:125627818-125627818

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.965G>A; p.R322H; 11:125644132-125644132

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1257G>T; p.R419S; 11:125653769-125653769

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1257G>T; p.R419S; 11:125653769-125653769

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.925G>A; p.E309K; 11:125644092-125644092

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1257G>T; p.R419S; 11:125653769-125653769

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

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