Cell senescence gene database Home
Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

1111

Name

CHEK1

Synonym

CHK1;checkpoint kinase 1;CHEK1;checkpoint kinase 1

Definition

CHK1 checkpoint homolog|Checkpoint, S. pombe, homolog of, 1|Chk1-S|cell cycle checkpoint kinase|checkpoint kinase-1|serine/threonine-protein kinase Chk1

Position

11q24.2

Gene Type

protein-coding

Pathways and Diseases

Pathway

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;PID Reactome;500938

Pathway

cell cycle: g2/m checkpoint;PID BioCarta;100159

Pathway

Activation of ATR in response to replication stress;PID Reactome;500319

Pathway

Circadian rhythm pathway;PID Curated;200068

Pathway

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;PID Reactome;500318

Pathway

Cell Cycle Checkpoints;Reactome;REACT:1538

Pathway

role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234

Pathway

G2/M DNA damage checkpoint;PID Reactome;500952

Pathway

regulation of cell cycle progression by plk3;PID BioCarta;100068

Pathway

cdc25 and chk1 regulatory pathway in response to dna damage;PID BioCarta;100212

Pathway

p53 signaling pathway;KEGG PATHWAY;hsa04115

Pathway

Cell cycle;KEGG PATHWAY;hsa04110

Pathway

atm signaling pathway;PID BioCarta;100235

Pathway

rb tumor suppressor/checkpoint signaling in response to dna damage;PID BioCarta;100046

Pathway

G2/M Checkpoints;PID Reactome;500874

Pathway

p53 pathway;PID Curated;200175

Disease

CANCER;GAD

Disease

Cancer;FunDO

Disease

Fanconi's anemia;FunDO

Disease

colorectal cancer;GAD

External Links

Links to Entrez Gene

1111

Links to all GeneRIF Items

1111

Links to iHOP

1111

Sequence Information

Nucleotide Sequence

>1111 : length: 4174
CTTTTAAATTTGCGTTGTAAGATTTATTTTGGCTCTCCCCGCCTGTTCTTTGCACATTAA
AAATGAAAAAGTTTGTAGAACTAAGCTAAGCAGATGGTCTTCCTGCAAAAAGACCGGGCT
GAAGTAAAGCATTGTTTTGGAGCTGGTTCACAGAAAAAAGGCAAAACTGGTTATCCTGAC
TTCAAGCTCCAACATAAACTGCTCGCTTTCTCCGGGAAACTTGCCCCGCCACACACACTT
GACTGCGTGGCCAGTTCTTTCGAAGCCTCTCGCTCCCAACACGGAGTTCCTCCCATTTCT
TCACAGTCGGCTCTCAGCAGCTGCTGCTGGTTTCTCGGCTCCAGCACCACGAGTACCGCA
CTCTGAGGTTTACAAAGCACTCTGCTTCACCGACTGTGATCCTCACAGTCCTGTCCGGTG
GCCTCACGCAGGTGGCGGTGCAGCCTTTCAGGCCCAGAGCGGCCAGGAGCGAAGCCCGCA
GCCCCGCCTGGAAGCGCAGCGCGGTCGGTCGCGCGCCCCTGAGGCTTGGAGGCCTGGGCT
TCCCCCAGCAGCGCTCGAGCACCGCCCAGTCGAGCCTCACACCGGATGCCACTTCATATT
TGGGCCCAGAGCTCAATTCGCGCCGATGCGGTCCGCCGTCCTTAAATCTCTTCAGCCAGG
ATCTCTCCCCGACTGCAAAGCAGCCCTGGGCGGGAGCGGCAACATCTCCACGTCACCCTT
TTGGAGCCGCCGACATTCAGAGGGGCAGGACACGGGAACGCGCGCTGTCTTGCTTTACGG
CGCGGGTGCGCGAGTTTGCGGCAGCGTGACGCCCTCAAGTTTTGGCGGGAAAAGCGCTGC
ATTTGGATTCCTGCAGTGGTGGGCAAAGGACAGTCCGCCGAGGTGCTCGGTGGAGTCATG
GCAGTGCCCTTTGTGGAAGACTGGGACTTGGTGCAAACCCTGGGAGAAGGTGCCTATGGA
GAAGTTCAACTTGCTGTGAATAGAGTAACTGAAGAAGCAGTCGCAGTGAAGATTGTAGAT
ATGAAGCGTGCCGTAGACTGTCCAGAAAATATTAAGAAAGAGATCTGTATCAATAAAATG
CTAAATCATGAAAATGTAGTAAAATTCTATGGTCACAGGAGAGAAGGCAATATCCAATAT
TTATTTCTGGAGTACTGTAGTGGAGGAGAGCTTTTTGACAGAATAGAGCCAGACATAGGC
ATGCCTGAACCAGATGCTCAGAGATTCTTCCATCAACTCATGGCAGGGGTGGTTTATCTG
CATGGTATTGGAATAACTCACAGGGATATTAAACCAGAAAATCTTCTGTTGGATGAAAGG
GATAACCTCAAAATCTCAGACTTTGGCTTGGCAACAGTATTTCGGTATAATAATCGTGAG
CGTTTGTTGAACAAGATGTGTGGTACTTTACCATATGTTGCTCCAGAACTTCTGAAGAGA
AGAGAATTTCATGCAGAACCAGTTGATGTTTGGTCCTGTGGAATAGTACTTACTGCAATG
CTCGCTGGAGAATTGCCATGGGACCAACCCAGTGACAGCTGTCAGGAGTATTCTGACTGG
AAAGAAAAAAAAACATACCTCAACCCTTGGAAAAAAATCGATTCTGCTCCTCTAGCTCTG
CTGCATAAAATCTTAGTTGAGAATCCATCAGCAAGAATTACCATTCCAGACATCAAAAAA
GATAGATGGTACAACAAACCCCTCAAGAAAGGGGCAAAAAGGCCCCGAGTCACTTCAGGT
GGTGTGTCAGAGTCTCCCAGTGGATTTTCTAAGCACATTCAATCCAATTTGGACTTCTCT
CCAGTAAACAGTGCTTCTAGTGAAGAAAATGTGAAGTACTCCAGTTCTCAGCCAGAACCC
CGCACAGGTCTTTCCTTATGGGATACCAGCCCCTCATACATTGATAAATTGGTACAAGGG
ATCAGCTTTTCCCAGCCCACATGTCCTGATCATATGCTTTTGAATAGTCAGTTACTTGGC
ACCCCAGGATCCTCACAGAACCCCTGGCAGCGGTTGGTCAAAAGAATGACACGATTCTTT
ACCAAATTGGATGCAGACAAATCTTATCAATGCCTGAAAGAGACTTGTGAGAAGTTGGGC
TATCAATGGAAGAAAAGTTGTATGAATCAGGTTACTATATCAACAACTGATAGGAGAAAC
AATAAACTCATTTTCAAAGTGAATTTGTTAGAAATGGATGATAAAATATTGGTTGACTTC
CGGCTTTCTAAGGGTGATGGATTGGAGTTCAAGAGACACTTCCTGAAGATTAAAGGGAAG
CTGATTGATATTGTGAGCAGCCAGAAGATTTGGCTTCCTGCCACATGATCGGACCATCGG
CTCTGGGGAATCCTGGTGAATATAGTGCTGCTATGTTGACATTATTCTTCCTAGAGAAGA
TTATCCTGTCCTGCAAACTGCAAATAGTAGTTCCTGAAGTGTTCACTTCCCTGTTTATCC
AAACATCTTCCAATTTATTTTGTTTGTTCGGCATACAAATAATACCTATATCTTAATTGT
AAGCAAAACTTTGGGGAAAGGATGAATAGAATTCATTTGATTATTTCTTCATGTGTGTTT
AGTATCTGAATTTGAAACTCATCTGGTGGAAACCAAGTTTCAGGGGACATGAGTTTTCCA
GCTTTTATACACACGTATCTCATTTTTATCAAAACATTTTGTTTAATTCAAAAAGTACAT
ATTCCATGTTGATTTAATTCTAAGATGAACCAATAAAGACATAATTCTTGTGACTTTTGG
ACAGTAGATTTATCAGTCTGTGAAGCGAAGCCAGCTTCAAAACATATCCCCAAGATTTGT
ACTTATATTTTCAAAAGGGCCTGGCCAGTTATATAAACCTGTTTTTGAATTATAATGATT
AATTAAAATTGCAAGTAGGTGTTTTTTCCAGTGTAGTTAGTAAAATACTTGTATTTTACA
GTGTTGCATAAACTCTAGTGCTTAACTAACTTTACTCTAAAAATTACTGTTGAACATCTT
AAATATTTTTCTATATTTTCTACTTTCATAGCCATATTTTAACCTTTTCAACTTACTGGT
GACCAAGCTTTTAGGTGATAAAGAATAAAAGAGGGAAGGGAAGAGTAAGGAAGCTATAAG
AAAAATAGATCTGATTCTTTGTTCCTTTACCTGTTAGACTTACAAAAAGTTTGTTTTTCT
AATAAAATTTGTATCAACTTTGGGGCATATTAGGTTGAGGCCTTGGCTCCTGCCTGTAGT
CCCAGCTACTTAGGAGGCTGAGAGAGGAGGATCGCGTGAACCTGGAAGTTTGAGGCTGTA
GTGAGCTATGATTGCACCAGTGCACTCCAGCTTGGATGACAGAGTAAGACCCTACCTCTA
ATAAAAATTTTTAAAATTGTAAAACATTATAAAATTAATCAGTTATTTTAATCTGAAGCC
AAGAACATGTAGAATGTTATGATTAGAGTTTATCACATATTAATGTATACTGGCAAATTG
TGTTACTGGAGTATACCCATAGGAGGAATAAATTCAAACCTGTTTTATTTATTTGAACCT
ATTTACGGTATGCTTAAGAATTGAATCAGTATAAATTCTCAAATATGGGAGAAATTTTGT
TCTTGAGAATTATCTGAGTCATTAATATTTTTCAAAAACAGCTCTCACTGACTTGAACCT
CTTCTGTAAGCTCTAACCTTTTACCTGCTTTACATTTCCACTTGAATGTCTAGTAGGCAT
CTCTTGACCAAAAACAGCTTTTGATTCCTGTTCTCCAACCTGTTCCTCTCCTAGTTTTCT
CCATCTCAGAAATGTTACTTCCTCTGCAAAGTCTTTCCCTGACTTATCTAAAATAATAAC
CTCCTCTGTTTGCTGTGGGAATTTGTATAGAATGGTGGGAAAATTTCAAGTTTCATATTT
GGATTAGCTCTGACATTTATTTATCTGAACACTGGTAATTGCCTCAGTAAAGACACTGAT
AATAAGTACCTTTTAGAGTTATTTTAATCTTTAATGCTTTAATGTGTAGGAAGAGTATAG
TGTCCTGTTTTGCACAGAAAGGCATTCTGTAAATAATAAGTTGCCTTAATTTTCCTGTAA
TGTTCATTATATTGTTGTGGGAAGGTATTTACTCCTATTATTAAAAATAAAAATGTGTAA
AATTTACTACCTGAAAAAAAAAAAAAAAAAAAAA

Protein Sequence

>1111 : length: 492
MRSAVLKSLQPGSLPDCKAALGGSGNISTSPFWSRRHSEGQDTGTRAVLLYGAGARVCGS
VTPSSFGGKSAAFGFLQWWAKDSPPRCSVESWQCPLWKTGTWCKPWEKVPMEKPDIGMPE
PDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLL
NKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEK
KTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVS
ESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISF
SQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQW
KKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLID
IVSSQKIWLPAT



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