| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7220 |
Name | TRPC1 |
Synonymous | transient receptor potential cation channel, subfamily C, member 1;TRPC1;transient receptor potential cation channel, subfamily C, member 1 |
Definition | TRP-1|capacitative calcium channel protein Trp1|short transient receptor potential channel 1|transient receptor potential canonical 1|transient receptor protein 1 |
Position | 3q23 |
Gene type | protein-coding |
Title | Abstract |
| nasopharyngeal cancer | The invasion and metastasis processes involved in nasopharyngeal carcinoma (NPC) remain enigmatic. Transient receptor potential channel-related protein 1 (TRPC1) is a cation channel involved in diverse cellular functions by precisely controlling Ca2+. The role of this unique TRPC member in nasopharyngeal malignancies has not yet been delineated. Here, we downregulated TRPC1 in CNE2 cells by RNAi technology and by using 2-APB, an inhibitor of the inositol 1,4,5-trisphosphate (IP3) receptor and of store-operated Ca2+ channel-mediated Ca2+ entry. Both types of TRPC1 inhibition resulted in significantly attenuated adhesive and invasive abilities, suggesting that TRPC1 can modulate the metastasis of NPC. These findings support further investigation of the potential of TRPC1 as a novel therapeutic target for intervention in nasopharyngeal carcinoma. |