Entrez Gene

Basic Information
Gene ID	7220
Name	TRPC1
Synonymous	transient receptor potential cation channel, subfamily C, member 1;TRPC1;transient receptor potential cation channel, subfamily C, member 1
Definition	TRP-1\|capacitative calcium channel protein Trp1\|short transient receptor potential channel 1\|transient receptor potential canonical 1\|transient receptor protein 1
Position	3q23
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.2119C>T; p.R707C; 3:142806074-142806074	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.551G>A; p.R184Q; 3:142777652-142777652	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2213G>A; p.R738Q; 3:142806168-142806168	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2213G>A; p.R738Q; 3:142806168-142806168	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2213G>A; p.R738Q; 3:142806168-142806168	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1921A>G; p.K641E; 3:142804499-142804499	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1929G>A; p.T643T; 3:142804507-142804507	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1929G>A; p.T643T; 3:142804507-142804507	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.727C>T; p.R243W; 3:142780898-142780898	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.223T>G; p.L75V; 3:142736429-142736429	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.129G>A; p.E43E; 3:142724688-142724688	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1074A>T; p.A358A; 3:142784919-142784919	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.754C>G; p.L252V; 3:142780925-142780925	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.238G>A; p.V80I; 3:142736444-142736444	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1889G>A; p.R630Q; 3:142804467-142804467	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1163G>T; p.R388I; 3:142785008-142785008	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.447A>T; p.V149V; 3:142748377-142748377	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1030A>T; p.R344*; 3:142784875-142784875	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2197G>T; p.D733Y; 3:142806152-142806152	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1873G>C; p.E625Q; 3:142804451-142804451	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1351G>C; p.D451H; 3:142792839-142792839	liver	carcinoma	Substitution - Missense
c.1504G>A; p.D502N; 3:142802193-142802193	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.959T>C; p.V320A; 3:142784804-142784804	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.914T>A; p.M305K; 3:142784759-142784759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.959T>C; p.V320A; 3:142784804-142784804	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.554G>A; p.C185Y; 3:142777655-142777655	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.554G>A; p.C185Y; 3:142777655-142777655	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2273G>T; p.R758I; 3:142806228-142806228	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2273G>T; p.R758I; 3:142806228-142806228	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1161A>G; p.E387E; 3:142785006-142785006	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1153G>A; p.A385T; 3:142784998-142784998	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.823C>T; p.R275C; 3:142780994-142780994	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.823C>T; p.R275C; 3:142780994-142780994	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.813G>T; p.M271I; 3:142780984-142780984	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.840C>A; p.I280I; 3:142781011-142781011	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.820A>T; p.S274C; 3:142780991-142780991	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1013C>T; p.P338L; 3:142784858-142784858	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.929G>A; p.R310H; 3:142784774-142784774	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.824G>A; p.R275H; 3:142780995-142780995	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1791C>T; p.V597V; 3:142804112-142804112	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.918G>A; p.S306S; 3:142784763-142784763	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.319G>A; p.G107S; 3:142736525-142736525	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.509A>G; p.K170R; 3:142748439-142748439	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1246T>G; p.F416V; 3:142791069-142791069	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1231G>A; p.E411K; 3:142791054-142791054	skin	malignant_melanoma	Substitution - Missense
c.1121A>G; p.Y374C; 3:142784966-142784966	breast	carcinoma	Substitution - Missense
c.1694T>C; p.F565S; 3:142804015-142804015	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1531C>T; p.L511F; 3:142802220-142802220	skin	malignant_melanoma	Substitution - Missense
c.427A>G; p.M143V; 3:142748357-142748357	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.373G>T; p.D125Y; 3:142748303-142748303	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.799T>C; p.L267L; 3:142780970-142780970	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1028G>A; p.G343D; 3:142784873-142784873	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2234T>C; p.L745P; 3:142806189-142806189	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2191C>T; p.R731C; 3:142806146-142806146	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1397G>T; p.G466V; 3:142792885-142792885	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.327G>A; p.Q109Q; 3:142736533-142736533	skin	malignant_melanoma	Substitution - coding silent
c.530+8C>T; p.?; 3:142748468-142748468	stomach	carcinoma; adenocarcinoma	Unknown
c.1189A>T; p.I397F; 3:142785034-142785034	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1727G>T; p.R576I; 3:142804048-142804048	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.98C>T; p.A33V; 3:142724657-142724657	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2161C>A; p.Q721K; 3:142806116-142806116	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.550C>T; p.R184*; 3:142777651-142777651	skin	malignant_melanoma	Substitution - Nonsense
c.1126G>C; p.E376Q; 3:142784971-142784971	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1126G>C; p.E376Q; 3:142784971-142784971	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1662T>C; p.I554I; 3:142803983-142803983	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1354C>T; p.R452W; 3:142792842-142792842	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1055A>C; p.K352T; 3:142784900-142784900	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1578T>C; p.D526D; 3:142802267-142802267	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1361A>T; p.D454V; 3:142792849-142792849	skin	malignant_melanoma	Substitution - Missense
c.1531C>A; p.L511I; 3:142802220-142802220	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.327+1G>A; p.?; 3:142736534-142736534	skin; trunk	malignant_melanoma	Unknown
c.676G>A; p.E226K; 3:142780847-142780847	breast	carcinoma	Substitution - Missense
c.1426T>A; p.Y476N; 3:142792914-142792914	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1716C>A; p.I572I; 3:142804037-142804037	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1716C>A; p.I572I; 3:142804037-142804037	breast	carcinoma	Substitution - coding silent
c.728G>A; p.R243Q; 3:142780899-142780899	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.728G>A; p.R243Q; 3:142780899-142780899	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2192G>A; p.R731H; 3:142806147-142806147	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1760T>C; p.V587A; 3:142804081-142804081	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1597G>A; p.E533K; 3:142802286-142802286	skin	malignant_melanoma	Substitution - Missense
c.1980G>A; p.M660I; 3:142804558-142804558	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2186A>G; p.E729G; 3:142806141-142806141	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1695C>A; p.F565L; 3:142804016-142804016	breast	carcinoma	Substitution - Missense
c.1625G>A; p.C542Y; 3:142802314-142802314	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1695C>A; p.F565L; 3:142804016-142804016	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.920G>A; p.G307D; 3:142784765-142784765	breast	carcinoma	Substitution - Missense
c.2147T>C; p.M716T; 3:142806102-142806102	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1519C>T; p.L507F; 3:142802208-142802208	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1519C>T; p.L507F; 3:142802208-142802208	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1655+1G>A; p.?; 3:142802345-142802345	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1655+1G>A; p.?; 3:142802345-142802345	breast	carcinoma	Unknown
c.868C>T; p.Q290*; 3:142784713-142784713	prostate	adenoma	Substitution - Nonsense
c.1438T>C; p.F480L; 3:142792926-142792926	breast	carcinoma	Substitution - Missense
c.1342G>A; p.D448N; 3:142792830-142792830	skin	malignant_melanoma	Substitution - Missense
c.2249C>T; p.S750F; 3:142806204-142806204	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1480-1G>T; p.?; 3:142802168-142802168	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.878G>A; p.C293Y; 3:142784723-142784723	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1031G>T; p.R344I; 3:142784876-142784876	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.127G>A; p.E43K; 3:142724686-142724686	breast	carcinoma	Substitution - Missense
c.50C>A; p.S17Y; 3:142724609-142724609	breast	carcinoma	Substitution - Missense
c.1193T>C; p.I398T; 3:142785038-142785038	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Substitution - Missense
c.1193T>C; p.I398T; 3:142785038-142785038	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1705C>A; p.H569N; 3:142804026-142804026	breast	carcinoma	Substitution - Missense
c.667G>A; p.D223N; 3:142780838-142780838	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1243G>T; p.D415Y; 3:142791066-142791066	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.856G>T; p.E286*; 3:142781027-142781027	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.805G>A; p.E269K; 3:142780976-142780976	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1336-1G>T; p.?; 3:142792823-142792823	lung	carcinoma; adenocarcinoma	Unknown
c.1062C>T; p.I354I; 3:142784907-142784907	skin	malignant_melanoma	Substitution - coding silent
c.2140C>G; p.Q714E; 3:142806095-142806095	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1305C>A; p.T435T; 3:142791128-142791128	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1693T>C; p.F565L; 3:142804014-142804014	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.36G>A; p.S12S; 3:142724595-142724595	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1693T>C; p.F565L; 3:142804014-142804014	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2110C>T; p.L704L; 3:142806065-142806065	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.220G>C; p.D74H; 3:142736426-142736426	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.613G>A; p.E205K; 3:142777714-142777714	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.613G>A; p.E205K; 3:142777714-142777714	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2110C>T; p.L704L; 3:142806065-142806065	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1229A>G; p.Y410C; 3:142791052-142791052	urinary_tract; bladder	carcinoma	Substitution - Missense
c.737G>A; p.R246H; 3:142780908-142780908	ovary	other; neoplasm	Substitution - Missense
c.737G>A; p.R246H; 3:142780908-142780908	ovary	other; neoplasm	Substitution - Missense
c.1324G>A; p.A442T; 3:142791147-142791147	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2094A>C; p.Q698H; 3:142806049-142806049	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.282C>T; p.N94N; 3:142736488-142736488	large_intestine; rectum	NS	Substitution - coding silent
c.341G>A; p.R114Q; 3:142748271-142748271	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.341G>A; p.R114Q; 3:142748271-142748271	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.809G>T; p.R270I; 3:142780980-142780980	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2000G>A; p.W667*; 3:142804578-142804578	skin	malignant_melanoma	Substitution - Nonsense
c.809G>T; p.R270I; 3:142780980-142780980	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.720A>C; p.A240A; 3:142780891-142780891	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1126G>T; p.E376*; 3:142784971-142784971	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1150C>T; p.P384S; 3:142784995-142784995	oesophagus	carcinoma	Substitution - Missense
c.2211C>T; p.F737F; 3:142806166-142806166	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1471C>T; p.P491S; 3:142792959-142792959	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.926G>T; p.R309L; 3:142784771-142784771	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1022A>C; p.Q341P; 3:142784867-142784867	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1623C>T; p.F541F; 3:142802312-142802312	breast	carcinoma	Substitution - coding silent
c.1432C>T; p.R478C; 3:142792920-142792920	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1744G>T; p.E582*; 3:142804065-142804065	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1437C>A; p.L479L; 3:142792925-142792925	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.745G>T; p.E249*; 3:142780916-142780916	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.172G>A; p.G58S; 3:142724731-142724731	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1273A>T; p.S425C; 3:142791096-142791096	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.521G>A; p.R174Q; 3:142748451-142748451	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]