| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 9641 |
Name | IKBKE |
Synonymous | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon;IKBKE;inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon |
Definition | I-kappa-B kinase epsilon|IKK-epsilon|IKK-related kinase epsilon|inducible I kappa-B kinase|inducible IkappaB kinase|inhibitor of nuclear factor kappa-B kinase subunit epsilon |
Position | 1q32.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IKK-i(h) + IRF-3(h) <==> IKK-i(h):IRF-3(h) (binding) | TRIF(h) + IKK-i(h) <==> TRIF(h):IKK-i(h) (binding) | IKK-i(h) + TANK(h) + IKK-gamma(h) <==> IKK-i(h):TANK(h):IKK-gamma(h) (binding) | IKK-i(h) + TANK(h) + IKK-alpha(h) <==> IKK-i(h):TANK(h):IKK-alpha(h) (binding) | IKK-i(h) + TANK(h) <==> IKK-i(h):TANK(h) (binding) | 2 IKK-i(h) <==> IKK-i(h):IKK-i(h) (binding; oligomerization) | IKK-i(h) + ATP --> IKK-i(h){pS172} + ADP (phosphorylation) | TANK(h) + IKK-i(h) <==> TANK(h):IKK-i(h) (binding) | IKK-i(h) + ROCK-II(h) <==> IKK-i(h):ROCK-II(h) (binding) | IKK-i(h) + CHC(h) <==> IKK-i(h):CHC(h) (binding) | IKK-i(h) + LRP130(h) <==> IKK-i(h):LRP130(h) (binding) | IKK-i(h) + DustyPK(h) <==> IKK-i(h):DustyPK(h) (binding) | IKK-i(h) + QPRS(h) <==> IKK-i(h):QPRS(h) (binding) | IKK-i(h) + IMPDH2(h) <==> IKK-i(h):IMPDH2(h) (binding) | IKK-i(h) + MYH10(h) <==> IKK-i(h):MYH10(h) (binding) | IKK-i(h) + PabpC1(h) <==> IKK-i(h):PabpC1(h) (binding) | IKK-i(h) + ATP-citrate synthase(h) <==> IKK-i(h):ATP-citrate synthase(h) (binding) | IKK-i(h) + bifunctional purine biosynthesis protein PURH(h) <==> IKK-i(h):bifunctional purine biosynthesis protein PURH(h) (binding) | IKK-i(h) + vcp(h) <==> IKK-i(h):vcp(h) (binding) | IKK-i(h) + T-plastin(h) <==> IKK-i(h):T-plastin(h) (binding) | IKK-i(h) + PR65-alpha(h) <==> IKK-i(h):PR65-alpha(h) (binding) | IKK-i(h) + Reptin52(h) <==> IKK-i(h):Reptin52(h) (binding) | IKK-i(h) + LeuRS(h) <==> IKK-i(h):LeuRS(h) (binding) | IKK-i(h) + XAPC7(h) <==> IKK-i(h):XAPC7(h) (binding) | IKK-i(h) + TXNDC7(h) <==> IKK-i(h):TXNDC7(h) (binding) | IKK-i(h) + snd1(h) <==> IKK-i(h):snd1(h) (binding) | IKK-i(h) + Orp150(h) <==> IKK-i(h):Orp150(h) (binding) | IKK-i(h) + RFP(h) <==> IKK-i(h):RFP(h) (binding) | IKBKE(h) --> IKK-i(h) (expression). | IFNalpha1(h) --> IKK-i(h) (increase of abundance) | IkappaB-alpha(h) + ATP --IKK-i(h)--> IkappaB-alpha(h){pS36} + ADP (phosphorylation) | RelA-p65(m.s.) + ATP --IKK-i(h)--> RelA-p65(m.s.){pS536} + ADP (phosphorylation) | IKK-i(h) + HCV-NS3-1B(HCV1B) <==> IKK-i(h):HCV-NS3-1B(HCV1B) (binding) | IKK-i(h) + TANK(h) <==> IKK-i(h):TANK(h) (binding) | IKK-i(h) + TANK(h) <==> IKK-i(h):TANK(h) (binding) | sike(h) + IKK-i(h) <==> sike(h):IKK-i(h) (binding) | IKK-i(h) + A20(m.s.) <==> IKK-i(h):A20(m.s.) (binding) | RFP(h) + IKK-i(h) <==> RFP(h):IKK-i(h) (binding) | IKBKE(h) --> IKK-i(h) (expression). | TANK(h) + ATP --IKK-i(h)--> TANK(h){p} + ADP (phosphorylation) | c-Rel(m.s.) + ATP --IKK-i(h)--> c-Rel(m.s.){p} + ADP (phosphorylation) | RelA-p65(h) + 2 ATP --IKK-i(h)--> RelA-p65(h){pS468}{pS536} + 2 ADP (phosphorylation) | IRF-3(m.s.) + ATP --IKK-i(h)--> IRF-3(m.s.){p} + ADP (phosphorylation) | IRF-7(m.s.) + ATP --IKK-i(h)--> IRF-7(m.s.){p} + ADP (phosphorylation) |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 172 | Phosphoserine. | Swiss-Prot 53.0 | 172 | Phosphoserine | 11839743 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for IKBKE | ||