| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 9564 |
Name | BCAR1 |
Synonymous | breast cancer anti-estrogen resistance 1;BCAR1;breast cancer anti-estrogen resistance 1 |
Definition | Cas scaffolding protein family member 1|Crk-associated substrate p130Cas|breast cancer anti-estrogen resistance protein 1 |
Position | 16q23.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | FAK1(h) + Cas(h) <==> FAK1(h):Cas(h) (binding) | Cas(h) + BCAR-3(m) <==> Cas(h):BCAR-3(m) (binding) | Cas(h) + Pyk2-isoform1(h) <==> Pyk2-isoform1(h):Cas(h) (binding) | PTP1B(h) + Cas(h) <==> PTP1B(h):Cas(h) (binding) | PTP1B-p42(h) + Cas(h) <==> PTP1B-p42(h):Cas(h) (binding) | crk(h) + Src(h) + Cas(h) + EGFR(h) + CD51(h):beta3-integrin(h) <==> crk(h):Src(h):Cas(h):EGFR(h):CD51(h):beta3-integrin(h) (binding) | Src(h) + CD51(h):beta3-integrin(h) + Cas(h) + EGFR(h){pY} <==> Src(h):CD51(h):beta3-integrin(h):Cas(h):EGFR(h){pY} (binding) | Cas(h) + EGFR(h) + CD51(h) + beta3-integrin(h) + Src(h) <==> Cas(h):EGFR(h):CD51(h):beta3-integrin(h):Src(h) (binding) | Cas(h) + ATP --> Cas(h){pY} + ADP (phosphorylation) | Sh2d3c(m) + Cas(h) <==> Sh2d3c(m):Cas(h) (binding) | Cas(h) + CrkL(h) <==> Cas(h):CrkL(h) (binding) | Cas(h) + crkII(h) <==> Cas(h):crkII(h) (binding) | Cas(h) + Crk-II(m.s.) <==> Cas(h):Crk-II(m.s.) (binding) | Cas(h) + Fyn(h){pY} <==> Cas(h):Fyn(h){pY} (binding) | SHP-2(h) + Cas(h) <==> SHP-2(h):Cas(h) (binding) | Cas(h) + Pyk2(h) <==> Cas(h):Pyk2(h) (binding) | Lyn(h) + Cas(h) <==> Lyn(h):Cas(h) (binding) | Fyn(h) + Cas(h) <==> Fyn(h):Cas(h) (binding) | Id2(h) + Cas(h) <==> Id2(h):Cas(h) (binding) | trip6(m.s.) + Cas(h) <==> trip6(m.s.):Cas(h) (binding) | 14-3-3sigma(m.s.) + Cas(h) <==> 14-3-3sigma(m.s.):Cas(h) (binding) | Cas(h) + GRP78(h) <==> Cas(h):GRP78(h) (binding) | BCAR1(h) --> Cas(h) (expression). | Cas(h){p} --PTP-PEST(h)--> Cas(h) + p (dephosphorylation) | Cas(h){pY} --PTP1B(c)--> Cas(h) + p (oligomerization) | Cas(h) + CIZ8(r) <==> Cas(h):CIZ8(r) (binding) | zyxin(h) + Cas(h) + CIZ(h) <==> zyxin(h):Cas(h):CIZ(h) (binding) | CIZ(h) + Cas(h) <==> CIZ(h):Cas(h) (binding) | BCAR1(h) --> Cas(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 128 | Phosphotyrosine. | Swiss-Prot 53.0 | 139 | Phosphoserine. | Swiss-Prot 53.0 | 222 | Phosphotyrosine. | Swiss-Prot 53.0 | 224 | Phosphotyrosine. | Swiss-Prot 53.0 | 234 | Phosphotyrosine. | Swiss-Prot 53.0 | 249 | Phosphotyrosine. | Swiss-Prot 53.0 | 327 | Phosphotyrosine. | Swiss-Prot 53.0 | 362 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 387 | Phosphotyrosine. | Swiss-Prot 53.0 | 410 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 639 | Phosphoserine. | Swiss-Prot 53.0 | 664 | Phosphotyrosine (FAK) | 8621540;11604500 | Phospho.ELM 6.0 | 653 | Phosphotyrosine (FAK;Src) | 11604500;8670206;12480533 | Phospho.ELM 6.0 | 128 | Phosphotyrosine (FGFR1) | 12601080 | Phospho.ELM 6.0 | 249 | Phosphotyrosine (FGFR1) | 12601080 | Phospho.ELM 6.0 | 306 | Phosphotyrosine (FGFR1) | 12601080 | Phospho.ELM 6.0 | 327 | Phosphotyrosine (FGFR1) | 12601080 | Phospho.ELM 6.0 | 410 | Phosphotyrosine (FGFR1) | 12601080 | Phospho.ELM 6.0 | 387 | Phosphotyrosine | 15316024 | Phospho.ELM 6.0 | 165 | Phosphotyrosine | 15817476 | Phospho.ELM 6.0 | 639 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr16 |
Promoter: 73842504 - 73844504 | Agilent_014791 |
chr16 |
Promoter: 73842504 - 73844504 | GSE27584 |
chr16 |
Promoter: 73842504 - 73844504 | Agilent_014791_44K |