| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 891 |
Name | CCNB1 |
Synonymous | cyclin B1;CCNB1;cyclin B1 |
Definition | G2/mitotic-specific cyclin B1|G2/mitotic-specific cyclin-B1 |
Position | 5q12 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | cyclinB1(h) + ATP --plk1(h)--> cyclinB1(h){pS147} + ADP (phosphorylation) | plk1(h) + cyclinB1(h) <==> plk1(h):cyclinB1(h) (binding) | cyclinB1(h) + ATP --plk1(h)--> cyclinB1(h){pS133} + ADP (phosphorylation) | cyclinB1(h) + 2 ATP --cyclinB1(h):Cdk1(h)--> cyclinB1(h){pS126}{pS128} + 2 ADP (phosphorylation) | cyclinB1(h) + 2 ATP --ERK2(m){pT183}{pY185}--> cyclinB1(h){pS126}{pS128} + 2 ADP (phosphorylation) | PC3(v.s.) + cyclinB1(h) <==> PC3(v.s.):cyclinB1(h) (binding) | cyclinB1(h) + Ptc1(m) <==> cyclinB1(h):Ptc1(m) (binding) | cyclinB1(h) + Ptc1(h) <==> cyclinB1(h):Ptc1(h) (binding) | cyclinB1(h) + brca1(h) <==> cyclinB1(h):brca1(h) (binding) | cyclinB1(h) + MGMT(h) <==> cyclinB1(h):MGMT(h) (binding) | SET-isoform2(h) + cyclinB1(h) <==> SET-isoform2(h):cyclinB1(h) (binding) | cyclinB1(h) + Cdk1(h) <==> cyclinB1(h):Cdk1(h) (binding) | cyclinB1(h) --26S proteasome(h)--> protein remnants (degradation) | cyclinB1(h) + Separin(h){pS1126} <==> cyclinB1(h):Separin(h){pS1126} (binding) | cyclinB1(h) + Separin(h) <==> cyclinB1(h):Separin(h) (binding) | cyclinB1(h) + RIP1(h) <==> cyclinB1(h):RIP1(h) (binding) | cyclinB1(h) + RIP1(h) <==> cyclinB1(h):RIP1(h) (binding) | cyclinB1(h) + RIP1(m.s.) <==> cyclinB1(h):RIP1(m.s.) (binding) | cyclinB1(h) + ubiquitin(b) --cyclosome(h):Cdc20(h)--> cyclinB1(h){ub}n (ubiquitination) | cyclinB1(h) --> protein remnants (degradation) | Separin(h) + cyclinB1(h) <==> Separin(h):cyclinB1(h) (binding) | CCNB1(h) --> cyclinB1(h) (expression). | Cdk1(h) --> cyclinB1(h) (binding) | CBP(h) --/ cyclinB1(h) (decrease of abundance) | HCV-NS5A-1A-H(HCV1AH) --/ cyclinB1(h) (decrease of abundance) | Emi1(h) --> cyclinB1(h) (increase of abundance) | NRG1(h) --> cyclinB1(h) (increase of abundance) | ALY(h) --> cyclinB1(h) (increase of abundance) | Abeta40(m.s.) + cyclinB1(h) <==> Abeta40(m.s.):cyclinB1(h) (binding) | cyclinB1(h) + Abeta25-35(m.s.) <==> cyclinB1(h):Abeta25-35(m.s.) (binding) | cyclinB1(h) + ubiquitin(b) --cyclosome(x):Cdc20(h),E1(h),E2-C(m.s.)--> cyclinB1(h){ub}n (ubiquitination) | cyclinB1(h) --> protein remnants (degradation) | Separin(m.s.) + securin(m.s.) + cyclinB1(h) <==> Separin(m.s.):securin(m.s.):cyclinB1(h) (binding) | Separin(m.s.) + cyclinB1(h) + Cdk1(h) <==> Separin(m.s.):cyclinB1(h):Cdk1(h) (binding) | cyclinB1(h) + ubiquitin(b) --E1(rb),cyclosome(h)--> cyclinB1(h){ub}n (ubiquitination) | cyclinB1(h) + Cdc20(m.s.) <==> cyclinB1(h):Cdc20(m.s.) (binding) | Fzr1(m.s.) + cyclinB1(h) <==> Fzr1(m.s.):cyclinB1(h) (binding) | CCNB1(h) --> cyclinB1(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 133 | Phosphoserine (PLK1) | 11242082 | Phospho.ELM 6.0 | 147 | Phosphoserine (PLK1) | 11242082 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr5 |
Promoter: 68497169 - 68499169 | Agilent_014791 |
chr5 |
Promoter: 68497169 - 68499169 | GSE27584 |
chr5 |
Promoter: 68497169 - 68499169 | Agilent_014791 |