| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 8837 |
Name | CFLAR |
Synonymous | CASP8 and FADD-like apoptosis regulator;CFLAR;CASP8 and FADD-like apoptosis regulator |
Definition | FADD-like antiapoptotic molecule 1|MACH-related inducer of toxicity|caspase homolog|caspase-eight-related protein|caspase-like apoptosis regulatory protein|caspase-related inducer of apoptosis|cellular FLICE-like inhibitory protein|inhibitor of FLICE|usur |
Position | 2q33-q34 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | CARD4(h) + c-FLIP-L(h) <==> CARD4(h):c-FLIP-L(h) (binding) | c-FLIP-L(h) + FADD(h) + Fas(m) <==> c-FLIP-L(h):FADD(h):Fas(m) (binding) | c-FLIP-L(h) + proCaspase-8(h) <==> c-FLIP-L(h):proCaspase-8(h) (binding) | c-FLIP-L(h) --> Caspase-8-p43(h) (decrease of cleavage) | c-FLIP-L(h) + FADD(m.s.) <==> c-FLIP-L(h):FADD(m.s.) (binding) | Apo2L(h) + c-FLIP-L(h) <==> Apo2L(h):c-FLIP-L(h) (binding) | c-FLIP-L(h) + ATP --PKC(h)--> c-FLIP-L(h){p} + ADP (phosphorylation) | proCaspase-8(m.s.) + c-FLIP-L(h) <==> proCaspase-8(m.s.):c-FLIP-L(h) (binding) | Bcl-xL(m.s.) + c-FLIP-L(h) <==> Bcl-xL(m.s.):c-FLIP-L(h) (binding) | c-FLIP-L(h) + proCaspase-3(m.s.) <==> c-FLIP-L(h):proCaspase-3(m.s.) (binding) | Fas(h) + c-FLIP-L(h) <==> Fas(h):c-FLIP-L(h) (binding) | c-FLIP-L(h) + Daxx(h) <==> c-FLIP-L(h):Daxx(h) (binding) | c-FLIP-L(h) --> c-FLIP-L-p43(h) + protein remnants (cleavage) | c-FLIP-L(h) + DR5(h) <==> c-FLIP-L(h):DR5(h) (binding) | Apo2L(h) + DR5(h) + FADD(h) + proCaspase-8(h) + c-FLIP-L(h) <==> Apo2L(h):DR5(h):FADD(h):proCaspase-8(h):c-FLIP-L(h) (binding) | proCaspase-8(h) + FADD(h) + RIP(h) + c-FLIP-L(h) <==> proCaspase-8(h):FADD(h):RIP(h):c-FLIP-L(h) (binding) | proCaspase-8(h) + FADD(h) + RIP(h) + c-FLIP-L(h) + c-FLIP-S(h) <==> proCaspase-8(h):FADD(h):RIP(h):c-FLIP-L(h):c-FLIP-S(h) (binding) | c-FLIP-L(h) --> c-FLIP-L-p33(h) + c-FLIP-L-p22(h) (cleavage) | c-FLIP-L(h) + RIP2-isoform1(h) <==> c-FLIP-L(h):RIP2-isoform1(h) (binding) | c-FLIP-L(h) --> Fas(m):proCaspase-8(m) (decrease of binding) | c-FLIP-L(h) --> tBid(m) (decrease of cleavage) | c-FLIP-L(h) --> Bax(m){pS} (increase of phosphorylation) | c-FLIP-L(h) --> ERK(m){p} (decrease of phosphorylation) | c-FLIP-L(h) --/ p47phox(m) (decrease of abundance) | c-FLIP-L(h) --/ PKCalpha(m) (decrease of abundance) | c-FLIP-L(h) --/ PKC(m) (decrease of abundance) | c-FLIP-L(h) --/ PKCeta(m) (decrease of abundance) | c-FLIP-L(h) --/ PKCzeta(m) (decrease of abundance) | c-FLIP-L(h) --> Bax(m):PKC(m) (increase of binding) | c-FLIP-L(h) --> proCaspase-3(m) (decrease of processing) | c-FLIP-L(h) --> proCaspase-9(m) (decrease of processing) | c-FLIP-L(h) --> p38(m){p} (increase of phosphorylation) | c-FLIP-L(h) --> Bcl-xL(m) (increase of abundance) | c-FLIP-R(h) + c-FLIP-L(h) + proCaspase-8a(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L(h):proCaspase-8a(h):FADD(h):Fas(h) (binding) | c-FLIP-R(h) + c-FLIP-L(h) + proCaspase-8b(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L(h):proCaspase-8b(h):FADD(h):Fas(h) (binding) | c-FLIP-L(h) + proCaspase-8a(h) + Fas(h) <==> c-FLIP-L(h):proCaspase-8a(h):Fas(h) (binding) | c-FLIP-L(h) + proCaspase-8b(h) + Fas(h) <==> c-FLIP-L(h):proCaspase-8b(h):Fas(h) (binding) | CFLAR(h) --> c-FLIP-L(h) (expression). | IFNgamma(m.s.) --/ c-FLIP-L(h) (decrease of abundance) | c-FLIP-S(h) + FADD(h) <==> c-FLIP-S(h):FADD(h) (binding) | c-FLIP-S(h) + FADD(h) + Fas(m) <==> c-FLIP-S(h):FADD(h):Fas(m) (binding) | c-FLIP-S(h) + proCaspase-8(h) <==> c-FLIP-S(h):proCaspase-8(h) (binding) | c-FLIP-S(h) --> Caspase-8(h) (decrease of cleavage) | c-FLIP-S(h) + FADD(m.s.) <==> c-FLIP-S(h):FADD(m.s.) (binding) | Apo2L(h) + c-FLIP-S(h) <==> Apo2L(h):c-FLIP-S(h) (binding) | c-FLIP-S(h) + ATP --PKC(h)--> c-FLIP-S(h){p} + ADP (phosphorylation) | proCaspase-8(m.s.) + c-FLIP-S(h) <==> proCaspase-8(m.s.):c-FLIP-S(h) (binding) | c-FLIP-S(h) + proCaspase-3(m.s.) <==> c-FLIP-S(h):proCaspase-3(m.s.) (binding) | Apo2L(m.s.) + FADD(h) + c-FLIP-L-p43(h) + Caspase-8-p18(h) + c-FLIP-S(h) <==> Apo2L(m.s.):FADD(h):c-FLIP-L-p43(h):Caspase-8-p18(h):c-FLIP-S(h) (binding) | proCaspase-8(h) + FADD(h) + RIP(h) + c-FLIP-L(h) + c-FLIP-S(h) <==> proCaspase-8(h):FADD(h):RIP(h):c-FLIP-L(h):c-FLIP-S(h) (binding) | DR4(h) + DR5(h) + Caspase-8-p26(h) + FADD(h) + RIP(h) + c-FLIP-L-p43(h) + c-FLIP-S(h) <==> DR4(h):DR5(h):Caspase-8-p26(h):FADD(h):RIP(h):c-FLIP-L-p43(h):c-FLIP-S(h) (binding) | Fas(h) + Caspase-8-p43(h) + FADD(h) + RIP(h) + c-FLIP-L-p43(h) + c-FLIP-S(h) <==> Fas(h):Caspase-8-p43(h):FADD(h):RIP(h):c-FLIP-L-p43(h):c-FLIP-S(h) (binding) | Fas(h) + FADD(h) + c-FLIP-S(h) + c-FLIP-L-p43(h) + Caspase-8-p43(h) <==> Fas(h):FADD(h):c-FLIP-S(h):c-FLIP-L-p43(h):Caspase-8-p43(h) (binding) | proCaspase-8(h) + FADD(h) + c-FLIP-L-p43(h) + c-FLIP-S(h) <==> proCaspase-8(h):FADD(h):c-FLIP-L-p43(h):c-FLIP-S(h) (binding) | c-FLIP-S(h) --> protein remnants (degradation) | CFLAR(h) --> c-FLIP-S(h) (expression). | CD3(h) --> c-FLIP-S(h) (increase of abundance) | CD28(h) --> c-FLIP-S(h) (increase of binding) | TNF-alpha(h) --> c-FLIP-S(h) (increase of abundance) | IFNgamma(m.s.) --/ c-FLIP-S(h) (decrease of abundance) | CFLAR(h) --> FLAME-1beta(h) (expression). | FLAME-1alpha(h) --Caspase-8(h)--> FLAME-1alpha-p39(h) + FLAME-1alpha-p12(h) + protein remnants (processing) | Caspase-8(h) + FLAME-1alpha(h) <==> Caspase-8(h):FLAME-1alpha(h) (binding) | FLAME-1alpha(h) --Caspase-10(h)--> FLAME-1alpha-p39(h) + FLAME-1alpha-p12(h) + protein remnants (processing) | Caspase-10(h) + FLAME-1alpha(h) <==> Caspase-10(h):FLAME-1alpha(h) (binding) | 2 FLAME-1alpha(h) <==> (FLAME-1alpha(h))2 (binding) | CFLAR(h) --> FLAME-1alpha(h) (expression). | c-FLIP(h) --> c-FLIP-p22(h) + protein remnants (cleavage) | c-FLIP(h) + STAF130(h) <==> c-FLIP(h):STAF130(h) (binding) | c-FLIP(h) + p56Dok-2(h) <==> c-FLIP(h):p56Dok-2(h) (binding) | c-FLIP(h) + ubiquitin(h) --> c-FLIP(h){ub} (ubiquitination) | CFLAR(h) --> c-FLIP(h) (expression). | CFLAR(h) --> MRIT alpha-2(h) (expression). | CFLAR(h) --> I-FLICE-2(h) (expression). | CFLAR(h) --> I-FLICE-3(h) (expression). | CFLAR(h) --> I-FLICE-4(h) (expression). | CFLAR(h) --> I-FLICE-5(h) (expression). | CFLAR(h) --> FLAME-1 delta(h) (expression). | CFLAR(h) --> Usurpin beta(h) (expression). | CFLAR(h) --> Usurpin gamma(h) (expression). | CFLAR(h) --> c-FLIP-isoform-13(h) (expression). | CFLAR(h) --> c-FLIP-isoform-14(h) (expression). | Fas(h) + FADD(h) + c-FLIP-R(h) + c-FLIP-L-p43(h) + Caspase-8-p18(h) <==> Fas(h):FADD(h):c-FLIP-R(h):c-FLIP-L-p43(h):Caspase-8-p18(h) (binding) | c-FLIP-R(h) + c-FLIP-L(h) + proCaspase-8a(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L(h):proCaspase-8a(h):FADD(h):Fas(h) (binding) | c-FLIP-R(h) + c-FLIP-L(h) + proCaspase-8b(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L(h):proCaspase-8b(h):FADD(h):Fas(h) (binding) | c-FLIP-R(h) + c-FLIP-L-p43(h) + Caspase-8a-p43(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L-p43(h):Caspase-8a-p43(h):FADD(h):Fas(h) (binding) | c-FLIP-R(h) + c-FLIP-L-p43(h) + Caspase-8b-p41(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L-p43(h):Caspase-8b-p41(h):FADD(h):Fas(h) (binding) | CFLAR(h) --> c-FLIP-R(h) (expression). | CD3(h) --> c-FLIP-R(h) (increase of abundance) |
|---|
Post Translational Modification [Top] | |||
There is no record for CFLAR | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 201687635 - 201689635 | GSE27584 |
chr2 |
Promoter: 201687635 - 201689635 | Agilent_014791_44K |
chr2 |
Promoter: 201687635 - 201689635 | PMID:15788647 |
chr2 |
Promoter: 201687635 - 201689635 | PMID:14506696 |