| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7299 |
Name | TYR |
Synonymous | tyrosinase;TYR;tyrosinase |
Definition | LB24-AB|SK29-AB|monophenol monooxygenase|oculocutaneous albinism IA|tumor rejection antigen AB |
Position | 11q14.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | TYR(h) --> tyrosinase(h) (expression). | Calnexin(m) + tyrosinase(h) <==> Calnexin(m):tyrosinase(h) (binding) | CRT(m) + tyrosinase(h) <==> CRT(m):tyrosinase(h) (binding) | GRP78(m) + tyrosinase(h) <==> GRP78(m):tyrosinase(h) (binding) | tyrosinase(h) --> melanin (increase of abundance) | tyrosinase(h) + ATP --> tyrosinase(h){p} + ADP (phosphorylation) | TYR(h) --> tyrosinase(h) (expression). | p53(h) --> tyrosinase(h) (increase of abundance) | HPS5(h) --/ tyrosinase(h) (inhibition) | NCKX5(h) --> tyrosinase(h) (increase of abundance) | MATP-isoform1(h) --> tyrosinase(h) (increase of abundance) | NCKX5-xbb1(h) --> tyrosinase(h) (increase of abundance) | IL-1alpha(h) --/ tyrosinase(h) (decrease of abundance) | TNF-alpha(h) --/ tyrosinase(h) (decrease of abundance) | alpha-MSH(m.s.) --> tyrosinase(h) (increase of abundance) | LPS --> tyrosinase(h) (increase of abundance) | TYR(h) --> tyrosinase isoform-2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 86 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 111 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 161 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 230 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 337 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 371 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for TYR | ||