| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7010 |
Name | TEK |
Synonymous | TEK tyrosine kinase, endothelial;TEK;TEK tyrosine kinase, endothelial |
Definition | angiopoietin-1 receptor|endothelial tyrosine kinase|tunica interna endothelial cell kinase|tyrosine kinase with Ig and EGF homology domains-2|tyrosine-protein kinase receptor TEK|tyrosine-protein kinase receptor TIE-2 |
Position | 9p21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | ANG2(h) + Tie2(h) <==> ANG2(h):Tie2(h) (binding) | Tie2(h) + ATP --> Tie2(h){pY} + ADP (phosphorylation) | ANG4(m) + Tie2(h) <==> ANG4(m):Tie2(h) (binding) | ANG4(h) + Tie2(h) <==> ANG4(h):Tie2(h) (binding) | TEK(h) --> Tie2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 140 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 158 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 399 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 438 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 464 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 560 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 596 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 649 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 691 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 992 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1102 | Phosphotyrosine (Tie2) | 10521483;9632797;12082108 | Phospho.ELM 6.0 | 1113 | Phosphotyrosine (Tie2) | 10521483;12665569 | Phospho.ELM 6.0 | 1108 | Phosphotyrosine (Tie2) | 10521483;12665569 | Phospho.ELM 6.0 | 897 | Phosphotyrosine | 11080633;11513602 | Phospho.ELM 6.0 | 1048 | Phosphotyrosine (Tie2) | 11080633;11513602 | Phospho.ELM 6.0 | 992 | Phosphotyrosine (Tie2) | 11513602;93173509 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr9 |
Promoter: 27097786 - 27099786 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 27097786 - 27099786 | GSE27584 |