| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 6300 |
Name | MAPK12 |
Synonymous | mitogen-activated protein kinase 12;MAPK12;mitogen-activated protein kinase 12 |
Definition | MAP kinase 12|MAP kinase p38 gamma|extracellular signal-regulated kinase 6|mitogen-activated protein kinase 3|mitogen-activated protein kinase p38 gamma|stress-activated protein kinase 3 |
Position | 22q13.33 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | PSD-95(m.s.) + p38gamma(h) <==> PSD-95(m.s.):p38gamma(h) (binding) | PSD-95(h) + p38gamma(h) <==> PSD-95(h):p38gamma(h) (binding) | p38gamma(h) + ATP --> p38gamma(h){p} + ADP (phosphorylation) | p38gamma(h) + ubiquitin(m.s.) --> p38gamma(h){ub} (ubiquitination). | MAPK12(h) --> p38gamma(h) (expression). | Cot(m.s.) --> p38gamma(h) (activation) | MAPKAPK2(h) + ATP --p38gamma(h)--> MAPKAPK2(h){p} + ADP (phosphorylation) | c-Fos(h) + p38gamma(h) <==> c-Fos(h):p38gamma(h) (binding) | p38gamma(h) + ATP --> p38gamma(h){p} + ADP (phosphorylation) | MAPK12(h) --> p38gamma(h) (expression). | c-Fos(m) + ATP --p38gamma(h)--> c-Fos(m){pT232}{pT325}{pS374} + ADP (phosphorylation) | TAB1(h) + 2 ATP --p38gamma(h)--> TAB1(h){pT431}{pS438} + 2 ADP (phosphorylation) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 27 | Phosphotyrosine. | Swiss-Prot 53.0 | 183 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 185 | Phosphotyrosine. | Swiss-Prot 53.0 | 3 | Phosphoserine (MAPK12) | 10567720 | Phospho.ELM 6.0 | 183 | Phosphothreonine (MAP2K3;MAP2K) | 11062067 | Phospho.ELM 6.0 | 185 | Phosphotyrosine (MAP2K3;MAP2K) | 11062067 | Phospho.ELM 6.0 | 27 | Phosphotyrosine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr22 |
Promoter: 49041716 - 49043716 | Agilent_014791 |
chr22 |
Promoter: 49041716 - 49043716 | GoldenGate_Methylation_Cancer_Panel_I |
chr22 |
Promoter: 49041716 - 49043716 | GSE27584 |
chr22 |
Promoter: 49041716 - 49043716 | Agilent_014791_44K |