Entrez Gene

Basic Information
Gene ID	6300
Name	MAPK12
Synonymous	mitogen-activated protein kinase 12;MAPK12;mitogen-activated protein kinase 12
Definition	MAP kinase 12\|MAP kinase p38 gamma\|extracellular signal-regulated kinase 6\|mitogen-activated protein kinase 3\|mitogen-activated protein kinase p38 gamma\|stress-activated protein kinase 3
Position	22q13.33
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.925C>T; p.P309S; 22:50255296-50255296	skin	malignant_melanoma	Substitution - Missense
c.771G>A; p.E257E; 22:50255615-50255615	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.814G>A; p.D272N; 22:50255489-50255489	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.886G>A; p.A296T; 22:50255335-50255335	pancreas	carcinoma	Substitution - Missense
c.633T>C; p.S211S; 22:50255868-50255868	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.879G>A; p.V293V; 22:50255342-50255342	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.957T>G; p.D319E; 22:50255264-50255264	thyroid	other; neoplasm	Substitution - Missense
c.314+10G>A; p.?; 22:50258233-50258233	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1003C>A; p.R335S; 22:50255218-50255218	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.345C>A; p.D115E; 22:50257163-50257163	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.888G>A; p.A296A; 22:50255333-50255333	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.183T>C; p.P61P; 22:50261239-50261239	breast	carcinoma	Substitution - coding silent
c.468C>A; p.P156P; 22:50256635-50256635	skin; arm	malignant_melanoma	Substitution - coding silent
c.782A>G; p.Y261C; 22:50255521-50255521	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.330G>A; p.P110P; 22:50257178-50257178	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.465G>A; p.K155K; 22:50256638-50256638	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.694C>T; p.L232L; 22:50255692-50255692	lung	carcinoid-endocrine_tumour; atypical	Substitution - coding silent
c.1025-5G>C; p.?; 22:50253485-50253485	liver	carcinoma	Unknown
c.1025-5G>C; p.?; 22:50253485-50253485	liver	carcinoma	Unknown
c.1025-5G>C; p.?; 22:50253485-50253485	liver	carcinoma	Unknown
c.256-3_256-2insC; p.?; 22:50258303-50258304	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.845C>T; p.P282L; 22:50255458-50255458	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.764G>A; p.S255N; 22:50255622-50255622	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.903G>A; p.T301T; 22:50255318-50255318	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.903G>A; p.T301T; 22:50255318-50255318	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.308C>T; p.T103M; 22:50258249-50258249	urinary_tract; bladder	carcinoma	Substitution - Missense
c.262G>A; p.G88R; 22:50258295-50258295	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.457-1G>A; p.?; 22:50256647-50256647	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.693C>T; p.H231H; 22:50255693-50255693	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.933C>G; p.F311L; 22:50255288-50255288	central_nervous_system; brain	glioma	Substitution - Missense
c.256-3delC; p.?; 22:50258304-50258304	ovary	carcinoma; serous_carcinoma	Unknown
c.799G>A; p.E267K; 22:50255504-50255504	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.457-3_457-2insC; p.?; 22:50256648-50256649	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.738G>A; p.P246P; 22:50255648-50255648	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.309G>A; p.T103T; 22:50258248-50258248	skin	malignant_melanoma	Substitution - coding silent
c.34delT; p.Y12fs*5; 22:50261476-50261476	oesophagus	carcinoma; adenocarcinoma	Deletion - Frameshift
c.832A>G; p.T278A; 22:50255471-50255471	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.777G>T; p.K259N; 22:50255526-50255526	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1063C>T; p.R355W; 22:50253442-50253442	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.918G>A; p.L306L; 22:50255303-50255303	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.807G>A; p.E269E; 22:50255496-50255496	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.807G>A; p.E269E; 22:50255496-50255496	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.308C>G; p.T103R; 22:50258249-50258249	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.450C>A; p.I150I; 22:50256941-50256941	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.450C>A; p.I150I; 22:50256941-50256941	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.847C>G; p.L283V; 22:50255456-50255456	skin	malignant_melanoma	Substitution - Missense
c.572A>G; p.Y191C; 22:50256132-50256132	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.961_967delCCCCAGG; p.P321fs*>45; 22:50255254-50255260	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Deletion - Frameshift
c.550G>T; p.G184W; 22:50256154-50256154	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.523G>C; p.A175P; 22:50256181-50256181	urinary_tract; bladder	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]