Entrez Gene

Basic Information
Gene ID	5607
Name	MAP2K5
Synonymous	mitogen-activated protein kinase kinase 5;MAP2K5;mitogen-activated protein kinase kinase 5
Definition	MAP kinase kinase 5\|MAP kinase kinase MEK5b\|MAPK/ERK kinase 5\|MAPKK 5\|MEK 5\|dual specificity mitogen-activated protein kinase kinase 5
Position	15q23
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
MKK5(h) + ERK5(h) <==> MKK5(h):ERK5(h) (binding)
ERK5(h) + MKK5(h) <==> ERK5(h):MKK5(h) (binding)
MKK5(h) + MEKK3(m) <==> MKK5(h):MEKK3(m) (binding)
MAP2K5(h) --> MKK5(h) (expression).
alpha-enolase(m.s.) --> MKK5(h) (increase of abundance)
MAP2K5(h) --> MKK5-isoform2(h) (expression).
alpha-enolase(m.s.) --/ MKK5-isoform2(h) (decrease of abundance)
alpha-enolase(h) --/ MKK5-isoform2(h) (decrease of abundance)
MKK5-isoform1(h) + 4 ATP --ERK5(h)--> MKK5-isoform1(h){pS129}{pS137}{pS142}{pS149} + 4 ADP (phosphorylation)
MAP2K5(h) --> MKK5-isoform1(h) (expression).
ERK5(h) + 2 ATP --MKK5-isoform1(h)--> ERK5(h){pT218}{pY220} + 2 ADP (phosphorylation)

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
311	Phosphoserine.		Swiss-Prot 53.0
315	Phosphothreonine.		Swiss-Prot 53.0
315	Phosphothreonine	7759517	Phospho.ELM 6.0
311	Phosphoserine	7759517	Phospho.ELM 6.0
142	Phosphoserine (MAPK7)	12628002	Phospho.ELM 6.0
149	Phosphoserine (MAPK7)	12628002	Phospho.ELM 6.0
129	Phosphoserine (MAPK7)	12628002	Phospho.ELM 6.0
137	Phosphoserine (MAPK7)	12628002	Phospho.ELM 6.0

Transcription Factors [Top]